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Molecular Genetics Mastery Assignment Example Key 1. v What was Rosalind Franklin’s contribution to the discovery of DNA structure? (A) (B) (C) (D) She isolated the agent behind the transforming principle. She made important discoveries about the properties of nucleic acids. She photographed DNA using X-rays. She produced a structural model of DNA. 2. Which describes the composition of a chromosome? v (A) (B) (C) (D) 3. Which structure below is represented by A? v 4. v 5. v (A) (B) (C) (D) one very long DNA molecule one very long gene molecule thousands of protein molecules thousands of RNA molecules hydrogen bond nitrogen base phosphate sugar Which step in DNA replication involves the DNA unwinding and unzipping? (A) (B) (C) (D) elongation initiation proofreading and correction termination If the sequence of bases in one strand of DNA is GGC TAA, what is the sequence in the complementary strand? (A) (B) (C) (D) AAT CGG CCG ATT GGC TAA TTU GCC Amino Acids coded by RNA Codons Second Letter First Letter U C A G Third Letter phenylalanine serine tyrosine cysteine U phenylalanine serine tyrosine cysteine C leucine serine STOP STOP A leucine serine STOP tryptophan G leucine proline histidine arginine U leucine proline histidine arginine C leucine proline glutamine arginine A leucine proline glutamine arginine G isoleucine threonine asparagine serine U isoleucine threonine asparagine serine C isoleucine threonine lysine arginine A START/ methionine threonine lysine arginine G valine alanine aspartate glycine U valine alanine aspartate glycine C valine alanine glutamate glycine A valine alanine glutamate glycine G U C A G 6. v 7. v 8. v Using the RNA codon table above, which amino acids are coded by the DNA sequence GCT AAT? (A) (B) (C) (D) alanine-valine arginine-leucine serine-proline valine-glycine An anti-sense strand of DNA has bases ATC GAT CCG. Which is the correct sequence for bases on tRNA anticodons coded from this DNA? (A) (B) (C) (D) AUC GAU CCG TAG CTA GGC UAG CUA GGC CGG ATC GAT Which type of mutation involves a part of one chromosome changing place with a part of another chromosome? (A) (B) (C) (D) duplication inversion nondisjunction translocation B iology 3201 August 2007 Page 2 of 17 9. v 10. v Which diagnostic technique enables direct observation of a developing fetus? (A) (B) (C) (D) amniocentiesis chorionic villi sampling fetoscopy genetic markers Which technique allows for DNA fragments to be separated into bands forming a DNA fingerprint? (A) (B) (C) (D) cloning DNA amplification DNA sequencing gel electrophoresis (b) A mutation changed a DNA template sequence from AGC CCG GCA TTG to AGC CCG GGC ATT G. 11. % i) What type of gene mutation caused this change? Insertion - one nucleotide base added at position between bases 7 and 8. (1 mark) ii) Using the codon table provided on page 10, show how the polypeptide sequence changes from the original to the mutated strand. Arginine changes to proline - 1 mark Asparagine changes to “stop” codon - 1 mark B iology 3201 August 2007 Page 4 of 17