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Transcript
Cell Structure and Function Definition of a cell: basic structural and functional unit of life the smallest units that display the characteristics of life, i.e. reproduction, metabolism, response to stimuli General Subdivisions of a Cell • Plasma Membrane = selectively permeable boundary between the cell and the environment • Nucleus = regulatory center of the cell • Cytoplasm = everything between the plasma membrane and the nucleus (fluid + organelles) Plasma Membrane Structure • phospholipd bilayer • proteins embedded in, and attached to, the inner (intracellular) and outer (extracellular) surfaces • phospholipids are liquid at body temperature, so proteins float around in the membrane Plasma Membrane Function • Main responsibility: ensure the composition of extracellular fluid is not the same as the composition of the intracellular fluid • Selectively permeable barrier controls what enters and leaves the cell Plasma Membrane Function • Water-soluble substances (salts, nutrients) cross membrane with aid of protein channels, which are selective about what can pass through • Lipids can pass directly through bilayer by diffusion (movement from area of high pressure to area of low pressure) • Attachment site of cytoskeleton, the internal support of the cell Plasma Membrane Nucleus Nuclear Envelope (membrane) • Phospholipid bilayer with nuclear pores • Controls what enters/leaves the nucleus – things only go in or out by passing through Protein channels, which are selective • Encloses all the chromosomes Nucleus Chromatin • All the chromosomes, which are long strands of the molecule DNA • DNA regulates all cell activities, yet never leaves the nucleus; • produces RNA, short messenger molecules that exit through nuclear pores • RNA carries instructions out into the cytoplasm Nucleus Nucleolus • Site of ribosome synthesis • Compartment in the nucleus where ribsomes are assembled • Ribosomes are then moved out into cytoplasm through nuclear pores • Ribosomes and RNA work together outside the nucleus, to build all the proteins in the cell Nuclear Compartment Ribosomes Ribosomes = site of protein synthesis --assembled in the nucleolus --exported into the cytoplasm Free – unbound in the fluid cytoplasm, produce proteins for use in the cell Bound – attached to the endoplasmic reticulum (ER), produce proteins for export, or for the plasma membrane Cytoplasm Fluid portion = “cytoplasm” • Water with dissolved salts, nutrients and enzymes (= proteins that do a particular job) • Site of many metabolic reactions Cytoskeleton • Network of protein fibers extending throughout the fluid cytoplasm • Support and structure for the cell • Very dynamic, always remodeling itself • Critical for cells to divide and copy themselves Cell Structure Organelles • Separate compartments within the cytoplasm formed by membranes Mitochondrion – “thread granule” • major source of cell’s energy • energy is taken from sugar, stored in molecule called ATP (adenosine triphosphate) • requires oxygen to make this exchange (aerobic metabolism) • contained within double membrane Mitochondrion Organelles Cytomembrane System • system of tubes and chambers formed by membranes • extensively distributed throughout the fluid cytoplasm • involved in synthesis, modification, processing & packaging of cellular lipids and proteins Cytomembrane System Endoplasmic Reticulum (ER) = “within the cytoplasm network” • system of tubes and sacs formed by membranes (an enclosed space) Cytomembrane System • Two Types • Rough = with bound ribosomes – modifies proteins produced by the ribosomes • Smooth = without bound ribosomes – doesn’t modify proteins – functions in lipid synthesis, drug detoxification, carbohydrate metabolism Cytomembrane System Golgi Apparatus • series of flattened sacs formed by membranes, • functions in final protein processing prior to use by the cell • proteins get shuttled from the ER to one end of the Golgi Cytomembrane System Golgi Apparatus • in each sac, different modifications are made (proteins get individually tailored) • proteins get sorted and shipped off to their destination (like the post office of the cell) Cytomembrane System Vesicles • small membrane-bound structures that transport proteins and lipids around the cell • little transporters that shuttle their contents from one organelle to another • when they contact the appropriate organelle, they fuse with its outer membrane and dump their contents inside • same for plasma membrane, allowing the export of materials from the cell (exocytosis) Vesicles move from ER to Golgi Cytomembrane System Lysosome • membrane-bound vesicle that contains digestive enzymes or toxic chemicals • merges with vesicles containing food particles, invading bacteria • harsh chemicals and enzymes degrade the food or bacteria, without harming rest of cell