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Amyloid Deposition and Advanced Age Fails to Induce Alzheimer’s Type
Progression in a Double Knock-In Mouse Model
Gauri H. Malthankar-Phatak 1 ;Yin-Guo Lin 1 ;Nicholas Giovannone 1 ;Robert Siman 1, 2 ;
1 Department of Neurosurgery, University of Pennsylvania School of Medicine and ; 2 Center for Brain Injury and Repair, University of
Pennsylvania, Philadelphia, PA, USA ;
Figure 3 Retrograde labeling of the perforant pathway to evaluate neuronal loss, axonal atrophy and terminal degeneration in the aged DKI mouse. A–D Fluorogold
accumulation is depicted in the perforant pathway neurons of origin in layer II of the dorsal entorhinal cortex A-wild type, B-DKI and ventral entorhinal cortex C-wild type, DDKI; E- Quantitative analysis of the number of retrogradely labeled neurons in entorhinal layer II at 24–27 months of age n=8group; mea-medial entorhinal area; lea-lateral
entorhinal area. Scale bar=500 μm.
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