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Supplemental Figure Legends SFigure 1: Histopathology of livers from control neurons- or BEP neurons-transplanted groups. A representative liver section from an animal treated with control neurons shows well-differentiated hepatocellular carcinoma with compressed hepatic parenchyma (left). A representative liver section from an animal with BEP neuronal transplants shows almost normal liver morphology with mild fibrosis septae (right). SFigure 2: Representative picture of a back tumor, which developed in some control neuron transplanted animals following intravenous injection of MADB106 cells in female F344 rats. SFigure 3: In vitro release of cAMP at various timepoints from 70 nmol and 350 nmol dbcAMP attached to nanospheres. N =5. SFigure 4: Representative photomicrograph of a section of rat brain showing fluorescently-labeled-nanosphere attached with cAMP (N-cAMP; blue) in the area of 3rd ventricle. Also, showing many green fluorescent-labeled-BEP neurons within the arcuate nucleus. SFigure 5: Effect of nanosphere-delivered dbcAMP (N-cAMP) injection on tyrosine hydroxylase (TH) and corticotropin-releasing hormone (CRH) levels in the hypothalamus. (A) Representative photograph of the TH staining. (B) Total count of THpositive neurons in the PVN. (C) Representative photograph of the CRH staining. (D) Total count of CRH-positive neurons in the arcuate nucleus. 3V= 3rd ventricle. Data were analyzed using Students’ t-test. * P < 0.05 comparing to control group. N =5.