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This table was originally taken from the website:
http://www.uea.ac.uk/~b270/repair.htm, which was last modified in 2005. This version is from Dec. 2012. Please feel free to send me any updates/corrections- highlighted so that I can find them.
The references are not complete- to get current references, search for the gene ID or go to TAIR.
Human, E. coli or S.
cerevisiae gene
(synonyms)
Activity
Accession
number of
human, E. coli or
S. cerevisiae gene
Arabidopsis gene
(synonyms)
Comments
Nucleotide excision repair
1. XPC
2. RAD23B (HR23B)
3. CETN2
4. RAD23A (HR23A)
5. XPA
6. RPA1
Binds damaged
DNA as complex
Binds damaged
DNA as complex
NM_004628
At5g16630
NM_002874
At1g16190
RAD23a
At3g02540
At5g38470
RAD23c
RAD23d
At1g79650
RAD23b- mutant semisterile, altered phylotaxy
Farmer et al. 2010 Plant Cell 22:124
Binds damaged
DNA as complex
Substitutes for
HR23B
Binds damaged
DNA in preincision
complex
NM_004344
Binds DNA in
preincision complex
(70 kdal subunit of
RPA complex)
NM_ 002945
NM_005053
NM_000380
At3g50360
At4g37010
At1g79650
No significantly
similar protein
DNA replication, chiasma assembly, male gamete generation, male meiosis I, pollen
At2g06510
(RPA1A, RPA70A) development, reciprocal meiotic recombination, sensitive to DNA damaging agents, induced by
DNA damage (Takashi et al 2009 Plant Cell Phys., Chang et al. 2009 Plant Phys.)
At4g19130
(RPA1E)
At5g45400
(RPAC, RPA70C)
At5g08020
(RPA1B, RPA70B)
At5g61000
(RPA1D)
7. RPA2
8. RPA3
Binds DNA in
preincision complex
(medium subunit of
RPA complex)
Binds DNA in
preincision complex
(small subunit of
RPA complex)
NM_002946
At2g24490
At3g02920
NM_002947
At3g52630
At4g18590
1
TFIIH complex
9. XPB (ERCC3)
10. XPD (ERCC2)
Catalyzes unwinding
in preincision
complex
3' to 5' DNA
helicase
top of table
NM_000122
At5g41360
(AtXPB1)
At5g41370
(AtXPB2)
At1g03190
(UVH6/AtXPD)
5' to 3' DNA
helicase
X52221
11. GTF2H1
Core TFIIH subunit
p62
NM_005316
12. GTF2H2
Core TFIIH subunit
p44
Core TFIIH subunit
p34
Core TFIIH subunit
p52
Kinase subunit of
TFIIH
NM_001515
At3g61420
At1g55750
At1g55610
At1g05050
NM_001516
At1g18340
NM_001517
At4g17020
NM_001799
NM_001239
NM_002431
At4g30820
18. XPG (ERCC5)
Kinase subunit of
TFIIH
Kinase subunit of
TFIIH
3' incision
At1g18040
At1g66750
At1g73690
At5g27620
NM_000123
At3g28030
(UVH3)
19. ERCC1
5' incision subunit
NM_001983
20. XPF (ERCC4)
5' incision subunit
NM_005236
DNA joining
NM_000234
13. GTF2H3
14. GTF2H4
15. CDK7
16. CCNH
17. MNAT1
21. LIG1
AtXPB1 and AtXPB2: DNA sequences ~90% identical. Linked repeats. atxpb1 mutants:
hypersensitive to MMS, UV-C and HOCl, developmentally delayed, low seed viability, loss of
germination synchrony. Suggests NER is required for removal of lesions during seed storage,
germination and early plant development (Costa et al., 2001)
Gene isolation: Liu et al. (2003). uvh6-1 (missense) mutants are more sensitive to UV-B and UVC (Harlow et al., 1994), small and yellow and have a partial defect in the repair of 6-4
photoproducts (Jenkins et al., 1997; Liu et al. 2003). T-DNA insertion mutants exhibit recessive
lethality (Liu et al., 2003). Gene expressed in all tissues examined (Liu et al., 2003)
At3g61420 and are At1g55750 >80% identical at nt level
Identification of mutant: Jenkins et al., (1995). Gene isolation: Liu et al. (2001). Mutation confers
sensitivity to UV-C, continuous light, H2O2 and ionising radiation and exhibits early senescence
and reduced seed yield. Expressed in all tissues examined
Identification of mutant: Jiang et al. (1997), Hefner et al. (2003). Gene isolation: Hefner et al.
At3g05210
(UVR7/AtERCC1) (2003). Mutants are sensitive to gamma radiation (unlike human homolog), MMC, UV-B, MMS
(slightly) and exhibit 'gamma plantlet' response: irradiated seed germinate normally but the
production of first true leaves is substantially delayed. Like atrad1 mutants, atercc1 mutants
exhibit defective recombination (Dubest et al., 2004)
Identification of mutant: Harlow et al. (1994). Gene isolation: Gallego et al. (2000) Liu et al.
At5g41150
(AtRAD1/UVH1) (2000) Fidantsef et al. (2000). Gene expressed in all tissues examined. Mutants are sensitive to
ionising radiation, MMC, UV-B and UV-C. Mutants exhibit greatly reduced homologous
recombination in the presence of non-homologous overhangs (Dubest et al., 2002). atrad1 mutants
exhibit 'gamma plantlet' response: irradiated seed germinate normally but the production of first
true leaves is substantially delayed (Harlow et al., 1994; Jiang et al., 1997; Hefner et al., 2003).
AtLIGI: Taylor et al. (1998). Complements yeast cdc9 mutant. Expression induced by UV-B (West
At1g08130
et al., 2000), KO lethal (Waterworth et al. BMC Plant Biology 2009, 9:79 doi:10.1186/1471-2229-9-79)
(AtLIGI)
Required maternally for endosperm development probably through repair of breaks induced by DME
(Andreuzza et al Development 2010)
Functions in BER: required for completion of repair of uracil and abasic sites (Cordoba-Cañero, et al,
2011, Plant J 68, 693-702).
22. POLD1
23. POLE1
24. PCNA
NER and MMR pol
NER and MMR pol
Sliding clamp for
pol delta and pol
NM_002691
NM_006231
At5g63960
At2g27120
NM_002592
At1g08260
At2g29570
“TILTED1” Pol epsilon catalytic subunit- mild defects affect development and cell cycle
progression, lethal with atr KO (Jenik etal. 2005 Plant Cell)
“EarlyinShortDays7” also Pl eps. Cat. Subunit KO lethal, early flowering in weak allele Olmo et
al 2009 Plant J
PCNA2 interacts with pol eta to perform translesion synthesis in vitro (Kunz 2008 Plant Signaling
and Behavior)
2
epsilon
25. UvrD - E. coli
26. RAD16 - S.
cerevisiae
Excision helicase
Repair of silent
DNA
CAA25043.1
P31244
At1g07370
At4g25120
At1g02670
PCNA1
top of table
NER-related
27. CSA (CKN1)
28. CSB (ERCC6,
scRAD26)
30. DDB1
31. DDB2
32. MMS19
33. Mfd - E. coli
DNA
glycosylases
Cockayne syndrome;
needed for
transcriptioncoupled NER,
Cockayne syndrome;
needed for
transcriptioncoupled NER,
chromatin
remodeling, SNF2like
Complex defective
in XP group E
Mutated in XP group
E
Transcription and
NER
Recruits nuclease in
transcriptioncoupled NER
NM_000082
At1g27840
NM_000124
At1g19750
At5g63950
(CHR24)
(Okasabe et al. 2006 Plant J.)
NM_001923
NM_000107
At5g58760
UV-induced, reduced expression leads to UV sensitivity (Biedermann and Hellman 2010 Plant J)
AW852889
At5g48120
P30958
At3g02060
Major altered base
released
Cul4 RING ubiquitin ligase complex, involved in many aspects of development and photomorphogenesis,
response to UV, Molinier et al 2008 PLoS Genet 4(6): e1000093. doi:10.1371/journal.pgen.1000093
top of table
U
NM_003362
At3g18630
35. SMUG1
U
NM_014311
NM_003925
38. OGG1
U or T opposite G at
CpG sequences
U, T or ethenoC
opposite G
8-oxoG opposite C
No significantly
similar protein
At3g07930
NM_002542
No significantly
similar protein
At1g21710
39. MYH
A opposite 8-oxoG
NM_012222
At4g12740
37. TDG
Putative chromatin remodeling factors, gamma- and UV-sensitive (Shaked 2006)
At2g18760
(CHR8, aka
RAD26)
At4g05420
34. UNG
36. MBD4
Zhang et al. 2010, UV-S, MMS-S, aka CSAat1A, uvs90, Biedermann et al. 2010, assembles w’
DDB1 and CUL4, mutant UV repair defective
aka CSA1, CSAat1B,
NM_003211
Required for BER of uracil in Arabidopsis cell extracts; ung mutants exposed to 5-FU
accumulate uracil in their DNA (Córdoba-Cañero, et al., 2010, J Biol Chem 285, 7475-7483).
Exhibits in vitro 8-oxoG DNA glycosylase/lyase activity (Garcia-Ortiz, et al., 2001, Plant Mol
Biol 47, 795-804) (Dany and Tissier, 2001, Mol Genet Genomics 265, 293-301).
3
40. NTH1
Ring-saturated/
fragmented pyr
NM_002528
41. MPG
NM_002434
42. Fpg - E. coli
3-meA, ethenoA,
hypoxanthine
8-oxoG
43. TagI - E. coli
3-MeA
CAA27472.1
44. Mag1p - S.
cerevisiae
3-MeA
NP_011069.1
AP endonuclease
NM_001641
NP_418092
At2g31450
(AtNTH1)
At1g05900
At3g12040
(MAG)
At1g52500
AtNTH1: Roldan-Arjona et al. (2000). Exhibits in vitro DNA glycosylase apurinic/apyrimidinic
lyase activities
Santerre and Britt (1994). Complements MMS sensitivity of E. coli 3-methyladenine glycosylase
mutants
Exhibits in vitro 8-oxoG DNA glycosylase/lyase activity (Ohtsubo et al., 1998, Mol Gen Genet
259, 577-590).
At5g44680
At3g12710
At1g15970
At1g75090
At5g57970
At1g80850
At1g75230
At3g50880
Other BER
factors
45. APE1 (HAP1,
APEX, REF1)
At2g41460
(Arp)
At3g48425
(Ape1L)
46. APE2
47. ROS1 (plant
specific)
Arp: Babiychuk et al. (1994). Exhibits in vitro apurinic/apyrimidinic class II endonuclease
activity, Reduced human fos and jun in vitro, required (redundantly) for embryonic development,
base excision repair in chloroplasts, ….
Arp: Required for BER of uracil and abasic sites. Mutants are sensitive to 5-FU (Cordoba-Cañero, et atl,
2011, Plant J 68, 693-702.
Ape1L: Combined KO of Ape1L and Ape2 is lethal (Murphy et al., 2009, PLoS ONE 4, e4297).
Combined KO of Ape1L and Ape2 is lethal (Murphy et al., 2009, PLoS ONE 4, e4297).
AP endonuclease
5-meC, T
NM_014481
Plant specific
At4g36050
At2g36490
5-meC, T
Plant specific
At5g04560
These atypical DNA glycosylases remove not only 5-meC but also thymine mismatched to
guanine ,with a preference for a CpG context (Morales-Ruiz et al., 2006; Ortega-Galisteo et al.,
2008), therefore, they may also play a role in BER of DNA damage caused by spontaneous 5-meC
deamination.
“
5-meC, T
Plant specific
At3g10010
“
5-meC, T
Plant specific
At4g34060
“
Both lig1 and
exo/endo-like
domains
DNA 3´-phosphatase
5´-kinase
Plant specific
At1g66730
Bonatto et al 2005 (Functional Plant Biology). Involved in repair and seed germination/longevity
(Waterworth WM, et al. Plant J, 2010 Sep. PMID 20584150.) Role in repair of Ac excision sites (Huefner
NM_007254
At3G14890
(ZDP)
53. . XRCC1
Interacts with PARP,
LIG3 (not in plants),
and PolBeta (not in
plants)
NM_006297
At1g80420
54. ADPRT
Protects strand
interruptions
NM_001618
At2g31320
(AtPARP1)
At5g22470
48. DME (plant
specific)
49. DML2 (plant
specific)
50. DML3 (plant
specific)
51. . LIG6 (move to
dsb repair?)
52. PNKP
et al 2011 DNA Repair).
Exhibits DNA 3´phosphatase but no kinase activity (Petrucco et al., 2002, J Biol Chem 277,
23675-23683).
Functions in active DNA demethylation: by removing the blocking 3´-P generated by ROS1 after
5-meC excision; zdp mutants display an altered DNA methylation landscape; they are also
sensitive to MMS, suggesting a role of ZDP in BER (Martinez-Macias, et al., 2012, Mol Cell 45,
357-370).
top of table
AtPARP1: expression induced by ionizing radiation (Doucet-Chabeaud et al., 2001); this
induction requires AtATM (it is abolished in an atatm mutant; Garcia et al., 2003)
4
55. ADPRTL2
PARP-like enzyme
NM_005485
At4g02390
56. ADPRTL3
PARP-like enzyme
AF085734
At4g02390
(AtPARP2/APP)
more similar to ADPRL3
Doucet-Chabeaud et al. (2001). Expression induced by ionising radiation
Mismatch repair
57. MSH2
Mismatch and loop
recognition
58. MSH1
Localized to
mitochondria
Mismatch and loop
recognition
Mismatch
recognition
MutS homolog
specialized for
meiosis
MutS homolog
specialized for
meiosis
Plant-specific
homolog of
AtMSH6
Mitochondrial MutL
homolog
59. MSH3
60. MSH6
61. MSH4
62. MSH5
63. MSH7
64. PMS1
NM_000251
At3g18524
(AtMSH2)
NM_002440
At5g54090
At1g65070
At3g24320
(CHM1, MSH1)
At4g25540
(AtMSH3)
At4g02070
(AtMSH6-1)
At4g17380
NM_002441
At3g20475
NM_002439
NM_000179
NM_000534
65. MLH1
MutL homolog
NM_000249
66. PMS2
67. MLH3
MutL homolog
MutL homolog of
unknown function
NM_000535
NM_014381
AtMSH2:Ade et al. (1999) & Culligan and Hays (1997): identified as homolog; overexpression
leads to mutator phenotype in E. coli (Ade et al., 2001). atmsh2 mutants exhibit increased
microsatellite (dinucleotide repeat) instability (Leonard et al., 2003) Meiotic mutant phenotype
described in Emmanuel et al. 2006
Required for mitochondrial genome stability Abdelnoor 2003 PNAS
Ade et al. (1999): identified as homolog
Ade et al. (1999): identified as homolog
At3g24495
Culligan and Hays, 2000
At4g02460
(AtPMS1)
At4g35520
At4g09140
(AtMLH1)
At4g02460
At4g35520
Identified as an ortholog of yeast PMS1 by Alou et al. (2004) , role in stabilization of microsatellites
Expressed in flowers and cell cultures; induced by gamma irradiation and during mitotic S-phase
(Doutriaux et al., 1998). Mutant plants exhibit normal vegetative growth but defective male and
female meioses and are completely sterile (Li et al., 2004)
top of table
MMC-s (Bleuyard2005)
Mutant defective in Meiosis , MMC-s (Bleuyard2005)
Involved in both transcription and recombination during he defense response (Durrant et al. 2007,
PNAS)
Klimyuk and Jones (1997): meiosis specific expression. Expressed in flowers and cell cultures;
induced during mitotic S-phase (Doutriaux et al., 1998)
and in restrictio of homeologous somatic recombination (Liangliang et al 2008 PMB)
Jean et al. (1999): identified as homolog
At4g35520 more similar to PMS1. At4g02460 more similar to PMS2L3
Homologous recombination
68. RAD51
69. RAD51L1
(RAD51B)
70. RAD51C
71. RAD51L3
(RAD51D)
72. DMC1
73. RecA – E. coli
74. RecG – E. coli
Homologous pairing
NM_002875
At5g20850
(AtRAD51)
Rad51 homolog
U84138
At2g28560
Rad51 homolog
Rad51 homolog
NM_002876
NM_002878
At2g45280
At1g07745
Rad51 homolog,
meiosis
DNA strand
exchange
NM_007068
At3g22880
(AtDMC1)
At2g19490
At1g79050
At3g10140
At3g32920
Resolvase
BAA16561.1
CAA42123.1
At2g01440
No known function in Arabidopsis
5
75. XRCC2
DNA break and
cross-link repair
DNA break and
cross-link repair
Accessory factor for
DNA break and
cross-link repair and
homologous
recombination
DNA break and
cross-link repair and
homologous
recombination
Accessory factor for
transcription and
recombination
NM_005431
At5g64520
MMC-s, not IR sensitive, Bleuyard 2005
NM_005432
At5g57450
Mutant defective in meiosis (Bleuyard2005)
NM_002879
At1g71310
At5g47870
The two genes have splice variants that are targeted to different compartments Samach et al 2011
Plant Cell 23:4266
At3g19210
NM_007295
At4g21070
(AtBRCA1)
At1g04020
(BCD5)
80. BRCA2
Cooperation with
RAD51, essential
function
NM_000059
81. BRCC36
Deubiquitinase
activity, member of
several complexes
At5g01630
(AtBRCA2(V))
At4g00020
(AtBRCA2(IV))
At1g80210
(AtBRCC36A)
Member of the SWI2/SNF2 family of DNA-stimulated ATPases.
Shaked et al. 2006
Osakabe et al. 2006
Klutstein et al. 2008
The BCD5 and AtBRCA1 encoded proteins are related to both BRCA1 and BARD1 and may be
derived from an ancient progenitor of both. AtBRCA1 is expressed in all organs tested and
transcript levels are increased (up to 800-fold) by ionizing radiation (Lafarge and Montane, 2003).
AtBRCA1 exhibits E3 ubiquitin ligase activity (Stone et al., 2005). BRCA1 mutats are defective
in somatic recombination and MMC sensitive (Block-Schmidt 2011)
AtBRCA2(IV) and AtBRCA2(V) interact with AtRAD51 and AtDMC1. Plants in which both of
the AtBRCA2 genes are silenced exhibit partial sterility and meiotic defects (including the absence
of pairing, synapsis and bivalent formation, defects in anaphase I and II and chromosome
fragmentation) these phenotypes were Spo11 dependent (Siaud et al., 2004)
Epistatic to brca1 (Block-Schmidt etal., NAR, 2011)
76. XRCC3
77. RAD52
78. RAD54
79. BRCA1
82. RAD50
83. MRE11A
84. NBS1
ATPase in complex
with MRE11A,
NBS1
NM_005732
3' exonuclease
NM_005590
Mutated in
Nijmegen breakage
syndrome
At3g0680
(AtBRCC36B)
At2g31970
(AtRad50)
At5g54260
(AtMRE11)
At3g02680
Some sensitivity to MMC (Block-Schmidt etal., NAR, 2011)
AtRad50 is expressed in all tissues examined, with high transcript levels in tissues containing
many dividing cells (Gallego et al., 2001). atrad50 mutants are sterile and hypersensitive to MMS
(Gallego et al., 2001), and exhibit somatic hyper-recombination (Gherbi et al, 2001), progressive
telomere shortening, and (in cell culture) enhanced cell death (Gallego and White, 2001). The
AtRad50 protein interacts in planta with AtMRE11 (Daoudal-Cotterell et al., 2002)
Identified as homologue: Hartung and Puchta (1999). atmre11 mutants exhibit developmental
defects, including infertility, hypersensitivity to MMS and X-rays, lengthened telomeres, somatic
chromosome instability and Spo11-dependent chromosome fragmentation during meiosis
(Bundock and Hooykaas, 2002, Puizina et al., 2004). Protein interacts in planta with AtRad50
(Daoudal-Cotterell et al., 2002).
Waterworth et al 2007 Plant J doi: 10.1111/j.1365-313X.2007.03220.x
Interaction with yeast MRE11. Mutant exhibits sensitivity to MMS and MMC, enhances sterility of atm
mutants.
6
85. ATM
Ataxia telangiectasia
86. RECQ
helicases involved in
DNA repair and
homologous
recombination
NM_000051
At3g48190
(AtATM)
At3g05740
(RECQ1)
At1g31360
(RECQ2)
At4g35740
(RECQ3)
At1g10930
(RECQ4A)
At1g60930
(RECQ4B)
At1g27880
(RECQ5)
At5g27680
(RECQsim)
At4g13870
(WRNexo)
Garcia et al. (2000): identified as homolog. atatm mutants are hypersensitive to ionising radiation
and MMS (but not UV-B), fail to induce the transcription of genes involved in repair and are
partially sterile (Garcia et al., 2003)
RECQ1 identified as homolog by Hartung et al., 2000; rice homolog OsRECQ1 involved in RNA
silencing (Chen et al., 2008)
RECQ2: interacts with WRNexo in vitro (Hartung et al., 2000); unwinds partial duplex DNA, can
branch migrate Holliday junctions and promotes replication fork regression in vitro (Kobbe et al.,
2008)
RECQ3: unwinds partial duplex DNA and model replication forks in vitro (Kobbe et al., 2009)
RECQ4A: functional homolog of yeast Sgs1 and human BLM; involved in DNA repair of MMS,
Cisplatin-induced lesions; suppresses spontaneous somatic HR (Hartung et al., 2007); synthetically
lethal double mutant recq4A-4 mus81-1 (Hartung et al., 2006) that can be rescued by further
rad51C mutation (Mannuss et al., 2010); functions in conserved RTR complex with TOP3α and
RMI1 (Hartung et al., 2008); removes interchromosomal telomeric connections during meiotic
recombination (Higgins et al., 2011)
RECQ4B: promotes somatic HR (Hartung et al., 2007)
RECQ5: identified as homolog by Hartung et al., 2006
RECQsim: plant-specific homolog, contains large insertion in helicase domain (Hartung et al.,
2000); expression in yeast sgs1 mutant suppresses its MMS sensitivity (Bagherieh-Najjar et al.,
2003)
WRNexo: homologous to exonuclease domain of HsWRN (Hartung et al., 2000), similar in vitro
activities (Plchova et al., 2003); interacts with RECQ2 and Ku70 in vitro (Hartung et al., 2000; Li
et al., 2005)
Nonhomologous end joining
87. Ku70 (G22P1)
DNA end binding
NM_001469
At1g16970
(AtKu70)
88. Ku80 (XRCC5)
DNA end binding
M30938
At1g48050
At1g48050
(AtKu80)
89. PRKDC
DNA-dependent
protein kinase
catalytic subunit
Nonhomologous
end-joining
NM_006904
At1g50030
NM_002312
At5g57160
(AtLIG4)
Nonhomologous
end-joining
NM_003401
At3g23100
(AtXRCC4)
8-oxoGTPase
dUTPase
NM_002452
NM_001948
At1g68760
At3g46940
90. LIG4
91. XRCC4
92. MTH1 (NUDT1)
93. DUT
AtKu70 interacts with AtKu80; transcript accumulates in response to DSBs (Tamura et al., 2002).
atku70 mutants are hypersensitive to MMS and ionising radiation and exhibit increased telomere
length (Bundock et al., 2002; Riha et al., 2002). AtKu70 is required for telomeric C-rich strand
maintenance (Riha and Shippen, 2003)
At1g48050 more similar to Ku70
AtKu80 interacts with AtKu70; transcript accumulates in response to DSBs (Tamura et al., 2002).
atku80 mutants exhibit telomere lengthening, although telomerase activity per se is not increased
significantly (Gallego et al., 2003). Mutants are hypersensitive to ionising (but not UV) radiation
and exhibit reduced T-DNA intergration frequency (Friesner and Britt, 2003)
Encodes ATP-dependent DNA ligase; expression induced by UV-B and gamma irradiation;
protein interacts with AtXRCC4 (West et al., 2000). Mutants are hypersensitive to ionising (but
not UV) radiation (Friesner and Britt, 2003). One study suggests that mutants exhibit reduced TDNA intergration frequency (Friesner and Britt, 2003) but another found no such reduction (van
Attikum et al., 2003)
AtXRCC4 interacts with AtLIG4 (West et al., 2000)
top of table
Closely related (77.78% amino acid sequence identity) to known dUTP pyrophosphatase from
7
(DUT1)
tomato. dut1-RNAi lines grow slowly, die prematurely and are sensitive to 5-FU (Siaud et al.,
2010, DNA Repair, 9, 567-578); they also display an increased frequency of HR events (Dubois et
al., 2011, PLoS ONE 6, e18658.
DNA polymerases
94. POLL
95. POLG
96. REV3L (POLZ)
97. REV7 (MAD2L2)
98. REV1
99. POLH
100. POLI (RAD30B)
101. POLQ
102. DINB1
103. TRF4-1
104. TRF4-2
BER in nuclear
DNA
BER in
mitochondrial DNA
DNA pol zeta
catalytic subunit,
essential function
DNA pol zeta
subunit
dCMP transferase
XP variant
Lesion bypass
NM_013274
At1g10520
NM_002693
NM_002912
No significantly
similar protein
At1g67500
NM_006341
At1g16590
NM_016316
NM_006502
NM_007195
DNA cross-link
repair
Lesion bypass
Sister-chromatid
cohesion
Sister-chromatid
cohesion
NM_006596
At5g44750
At5g44740
At5g44740
At1g49980
At4g32700
NM_016218
AF089896
At1g49980
At5g53770
AF089897
At5g53770
At5g53770 is more similar to TRF4-1
Closely related (79.45% amino acid sequence identity) to rice OsFEN-1, which has 5'-flap
endonuclease and 5' to 3' double-stranded DNA exonuclease activities
105. FEN1 (DNase
IV)
106. TREX1 (DNase
III)
107. TREX2
5' nuclease
NM_004111
At5g26675
3' exonuclease
NM_016381
3' exonuclease
NM_007205
108. EX01 (HEX1)
109. SPO11
5' exonuclease
endonuclease
NM_003686
NM_012444
No significantly
similar protein
No significantly
similar protein
At1g29630
At5g02820
109.1 SPO11
At1g63990
109.2 SPO11
At3g13170
110. UBE2A
(RAD6A)
Ubiquitinconjugating enzyme
NM_003336
111. UBE2B
(RAD6B)
Ubiquitinconjugating enzyme
NM_003337
112. RAD18
Assists repair or
AB035274
At1g14400
(UBC1)
At2g02760
(UBC2)
At1g14400
(UBC1)
At2g02760
(UBC2)
At5g62540
(UBC3)
No significantly
There is only one member of the pol X polymerase family in Arabidopsis. Evidence for
involvement in repair of UV- and TE-induced damage, in vitro activity trans-8-oxoG
At5g44740 is more similar to POLH.
At1g49980 is more similar to DINB1
Involved in the patterning and shape of leaf trichomes. Encodes the DNA topoisomerase VI SPO11-3,
involved in endoreduplication
Spo11-2 Required for Meiotic Double-Strand Break Induction in Arabidopsis (Hartung 2007 Plant
Cell)
Spo11-1 Required for Meiotic Double-Strand Break Induction in Arabidopsis (Hartung 2007 Plant
Cell)
UBC1 exhibits in vitro activity (Sullivan and Vierstra, 1991). UBC2: Sullivan et al. (1994):
identified as homolog
UBC3: Sullivan et al. (1994): identified as homolog
8
113. UBE2VE
(MMS2)
replication of
damaged DNA
Ubiquitinconjugating complex
114. UBE2N (UBC13,
UbiquitinBTG1)
conjugating complex
similar protein
AF049140
NM_003348
At2g36060
At3g52560
At1g70660
At1g23260
At1g16890
At1g78870
Damage reversal
115. MGMT
O6-meG
alkyltransferase
NM_002412
No significantly
similar protein
top of table
Photoreactivation
116. Phr – E. coli
Photolyase
P00914
At4g08920
(CRY CRY1 and CRY2 encode a blue light photoreceptors (Ahmad et al., 1998a).
1)
At1g04400
(CRY
2)
UVR3 encodes a functional 6-4 photolyase (Jiang et al. 1997, Nakajima et al., 1998).
At5g24850 (CRY3) PHR2 encodes a protein related to photolyases (Ahmad et al., 1998b)
At3g15620
(UVR
3)
UVH2 encodes a functional CPD photolyase (Jiang et al. 1997)
At2g47590
(PH
R2)
At1g12370
(PHR1, UVR2)
Crosslink repair (see also XPF/ERCC1)
top of table
Fanconi anemia
117. FANCA
118. FANCB
119. FANCC
120. FANCD
121. FANCE
122. FANCF
123. FANCG
(XRCC9)
124. SNM1 (PS02)
125. SNM1B
(FLJ12810)
Involved in tolerance
or repair of DNA
cross-links
Involved in tolerance
or repair of DNA
cross-links
Involved in tolerance
or repair of DNA
cross-links
Involved in tolerance
or repair of DNA
cross-links
Involved in tolerance
or repair of DNA
cross-links
Involved in tolerance
or repair of DNA
cross-links
Involved in tolerance
or repair of DNA
cross-links
NM_000135
No significantly
similar protein
N/A
No significantly
similar protein
NM_000136
No significantly
similar protein
N/A
No significantly
similar protein
NM_021922
No significantly
similar protein
AF181994
No significantly
similar protein
NM_004629
No significantly
similar protein
DNA cross-link
repair
Related to SNM1
D42045
At3g26680
AL137856
At1g27410
FANC section needs updating
top of table
9
126. SNM1C
127. RPA4
Related to SNM1
Similar to RPA2
AA315885
NM_013347
128. ABH (ALKB)
Resistance to
alkylation damage
X91992
At3g26680
At3g02920
At2g24490
At1g11780
More similar to SNM1
At3g02920 and At2g24490 more similar to RPA2
Damage sensing- see also ATM (above)
129. ATR
ATM- and PI-3Klike essential kinase
NM_001184
At5g40820
(AtATR)
PCNA-like DNA
damage sensor
PCNA-like DNA
damage sensor
PCNA-like DNA
damage sensor
RFC-like DNA
damage sensor
NM_002853
At4g17760
NM_004584
At3g05480
(AtRAD9)
At1g52530
Mutants exhibit increased sensitivity to bleomycin and MMC, delayed repair of DSBs but
enhanced homologous recombination rates (Heitzeberg et al., 2004)
NM_002873
At5g66130
(AtRAD17)
Expression induced by bleomycin, MMC and gamma. Mutants exhibit increased sensitivity to
bleomycin and MMC, delayed repair of DSBs but enhanced homologous recombination rates
(Heitzeberg et al., 2004)
135. TP53BP1
136. CHEK1
BRCT protein
Effector kinase
NM_005657
NM_001274
137. CHK2 (Rad53)
Effector kinase
NM_007194
At5g40450
At2g26980
(CIPK3)
At4g04720
131. RAD1 (S. pombe)
homolog
132. RAD9 (S. pombe)
homolog
133. HUS1 (S. pombe)
homolog
134. spRAD17
(scRAD24)
NM_004507
Mutants viable (unlike animal nulls) and phenotypically normal in the absence of applied damage,
but are hypersensitive to treatment with agents that block replication (hydroxyurea, aphidicolin
and UV-B) and exhibit defective G2 arrest in response to aphidicolin (Culligan et al., 2004)
Kim et al. (2000). Interacts with CBL
Top of page
Partial list of References
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