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Spontaneous Damage to DNA Examples of DNA Damage Induced by Radiation and Chemicals Examples of DNA Damage Induced by Radiation and Chemicals Direct Repair of Thymine Dimers Not in humans A metiltransferase é gasta nesta reacção Base-Excision Repair Nucleotide-Excision Repair of Thymine Dimers Xeroderma pigmentosum •Autosomal recessive mutations in several complementation groups •Extreme sensitivity to sunlight •Predisposition to skin cancer (mean age of skin cancer = 8 yrs vs. 60 for normal population) Nucleotide excision repair - Energéticamente ineficiente Mismatch Repair in E. coli Teste de Ames para agentes mutagenicos
