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Ciencia Ergo Sum ISSN: 1405-0269 [email protected] Universidad Autónoma del Estado de México México Rivera Mulia, Juan Carlos; Aranda Anzaldo, Armando Estructura y función de la unidad fundamental de replicación del DNA (el replicón) en eucariontes Ciencia Ergo Sum, vol. 15, núm. 3, noviembre-febrero, 2008, pp. 269-286 Universidad Autónoma del Estado de México Toluca, México Available in: http://www.redalyc.org/articulo.oa?id=10415305 Abstract dna replication is necessary for the transmission of genetic information and thus such a process must achieve accurate copying of the genome. Since the last century the replicon model has been proposed in order to explain the general mechanism of genome duplication in bacteria. Later work in yeast lead to identifying proteins and dna sequences that participate in the initiation of replication in a similar fashion to what has been observed in prokaryotes. This led to attempts for generalizing the replicon model to eukaryotes. Several key factors involved in replication and conserved from yeast to man have been described to date. However, as yet, it is not understood how are determined the sites for the start of replication nor the structure of actual replicons in metazoans. In this article it is suggested that the topological organization of dna within the cell nucleus determines the structure and function of replicons in higher eukaryotes. Keywords chromatin, dna loops, nuclear matrix, mars, dna orc. How to cite Complete issue More information about this article Journal's homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative