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Silencing Genes for Life Dr David Suhy Thu 21 July 2016 Genomics is a branch of biotechnology concerned with the study and manipulation of the genome (the complete set of DNA within a single cell of an organism). One branch of Genomics is called RNA interference (RNAi). [RNA stands for Ribonucleic Acid]. Its inventors Andrew Fire and Craig Mello (Stanford University) were awarded the Nobel Prize in Physiology or Medicine in 2006. They showed that RNA could be used to silence (shut down expression of) the gene carrying the same code as the RNA. This discovery is the basis of Benitec’s technology, which has potential to treat a wide variety of human diseases by silencing the genes for Hepatitis A, B, C , HIV, Influenza, and Neurodegenerative diseases. RNAi is also showing promise in the treatment of cancers by silencing the genes which increase tumor or cancer cells. Dr. David Suhy will take us down the highway of our genetics and their control, much as other speakers have taken us into the understanding of the galactic highway and the universe. ----Dr David Suhy is Chief Scientific Officer, Benitec Biopharma Limited Before joining Benitec, Dr Suhy was Director of Research & Development at Tacere Therapeutics Inc. Previous roles include Associate Director of R&D at Clontech Laboratories Inc and Principal Scientist at Antara Biosciences Inc. He also led the Target Validation Group at PPD Discovery, a company with proprietary technology surrounding the use of genetic suppressor elements to identify "druggable" genomic targets for large pharmaceutical companies. Dr Suhy holds a Bachelor of Science in Biochemistry and Biophysics from the University of Pittsburgh, earned his PhD in Biochemistry, Molecular Biology and Cell Biology at Northwestern University, and conducted his post-doctoral work at Stanford University.