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Name:_______________________________________________________________________Test Date:___________________ Study Guide: DNA and Gene Technology Assessment DNA: Structures from largest to smallest: cell → nucleus→ chromosome → DNA → gene A gene is a set of instructions for each trait. o Genes are found on chromosomes. o Chromosomes are made up of DNA. Rosalind Franklin was able to create images of DNA molecules using X-Rays and discover that DNA was spiral shaped. Watson and Crick made models to determine DNA’s “twisted ladder” or double helix structure. According to Chargaff’s rules Adenine always pairs with Thymine and Cytosine always pairs with Guanine. A-T and C-G The complementary strand of: ATTGCCG TAACGGC is (because A goes to T and G always goes to C) The picture above is the basic structure of DNA and it is made of nucleotides. A nucleotide (pictured to the right) in a DNA molecule is made up of a sugar, a phosphate, and a base. In a DNA nucleotide, the middle of the “ladder” is made of four different nitrogen bases and the sides of the “ladder” are made of sugar and phosphate molecules. In DNA there are four different bases: Adenine, Thymine, Cytosine, and Guanine Genetic Engineering Cloning- process of making an identical copy of another organism using its DNA. Dolly, the sheep, is the first successfully cloned mammal because of genetic engineering. Mutations: A change in the order of bases in DNA is called a mutation. A mutation could be caused by x-rays, radioactivity, ultraviolet rays. A mutation in DNA could result in no change, death or a genetic disorder. Your phenotype (physical appearance) can be affected by heredity and the environment. • The environment can have an effect on a person’s genes: • o Ultraviolet radiation from the sun is known to cause mutations in skin cells that can lead to cancer o Smoking cigarettes can cause mutations in lung cells. Most genetic disorders (albinism, sickle cell anemia, etc.) are due to a recessive gene. Pedigree Chart: In a pedigree, squares represent males and circles represent females. A solid black square or circle indicates that the person has a certain trait. A blank square or circle indicates that a person DOES NOT have a certain trait. A half-filled square or circle indicates that the person is a carrier of a certain trait but does not show the trait.