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THE NUTRITION GENOME REPORT PREVIEW NUTRITION GENOME The Nutrition Genome Report looks at over 200 genes... The Nutrition Genome Report looks at over 200 genes and is organized by the following order: Your Final Results Digestion Methylation Hormone Health Neurotransmitters and Mental Health Inflammation and Antioxidant Protection Pharmacogenomics and Detoxification DNA Damage, Protection, and Repair Cardiovascular and Exercise Health What to expect in your report... The introduction of your report will explain how to read your genetic report, as well as a basic overview of your analysis. PATIENT OVERVIEW YOUR ANALYSIS PATIENT NAME: Your Name DATE OF ANALYSIS: Today’s Date NUTRITION GENOME ALEX J. SWANSON | M.S. http://nutritiongenome.com The Methylation Cycle Analysis Here is an example of the methylation section. You are given the gene, the gene function, and your specific variants. The paragraphs are customized based on your unique genotype. METHYLATION CYCLE B12, CALCIUM, LITHIUM, B6 & FOLATE: Heart Health, Reproductive Health, Brain Health, Pregnancy CHOLINE: Liver & Brain Health, Gallbladder, Pregnancy ZINC: Mental Health, Skin Health, Immune Health MAGNESIUM & VITAMIN C: Heart Health, Adrenal Health, Mental Health SAMPLE REPORT GENE FUNCTION NUTRIENT GENE GENE RSID NORMAL HETEROZYGOUS HOMOZYGOUS GENE GENE HETEROHOMONORMAL PEMT-rs4244593 TT RSID FUNCTION ZYGOUS ZYGOUS PEMT-rs4646406 TT The MTHFR C677T PEMT-rs7946 CT GENE MTHFR GENE GENE RSID NORMAL HETEROZYGOUS HOMOZYGOUS gene encodoes NBPF3 has been associated with vitamin NBPF3 C677T MTHFR AG FUNCTION C677TB6 levels. theMTHFR gene to NBPF3-rs4654748 -rs1801133 convert folategene into encodes The MTHFR C677T the MTHFR gene to convert folate CC into the active MTHFR the active form, Betaine-homocysteine methyltransferase (BHMT) catalyzes the remethylation of the form, methylfolate. Variants in this gene slow down enzymatic function, increasing BHMT C677T methylfolate. Varihomocysteine. need for folate and B2. ants in this gene slow MTHFR C677TBHMT-rs3797546 CT AG down enzymatic rs1801133 function, incraeasing CBS The Cystathione Beta-Synthase (CBS) enzyme pulls homocysteine hydrogen sulfide MTHFR A1298C is involved in converting 5-methylfolate (5MTHF) tototetrahydrofolate the need for folate MTHFR 191150T (H2S) glutathione, requiring B6 and SAMe as a modulator. (THF).and Unlike and B2.MTHFR C677T, the A1298C mutation does not lead to elevated A1298C Normal Variants Found homocysteine levels unless paired with a heterozygous MTHFR C677T. MTHFR A1298C CBS A360A-rs1801181 Normal Variants FoundAG CBS C699T-rs234706 A protein encoded by this gene is a transporter ofAG folate and is involved in the SLC19A1 regulation of intracellular concentrations of folate. SLC19A1-rs1051266 FOL1 METHYLATION ANALYSIS METHYLATION ANALYSIS FOL genes code for folate receptors. 3 genes tested. Folate-MTHFR 677 DHFR CC Normal Variants Found Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to metabolism. Improves MTHFR C677T Gene Function: Riboflavin methylfolate. A20965G tetrahydrofolate (THF) and affect and synthetic folic acid If you have a heterozygous MTHFR 677 (30% reduced function) antivirals, or homozygous Decreases Gene Function: PPI'S, birth control pills, NSAIDs, anticonvulsants, antibiotics(50% and acid Normal Variants Found blockers/antacids. reduced function) gene, your methylfolate requirement is higher. Reduced levels of methyl- MTR MTR (methionine synthase) combines folate, methyl B12 and homocysteine into folate lead to decreased production of neurotransmitters, reduced conversion of homocysteA2756G Research: If you methionine. have a heterozygous MTHFR 677 (30% reduced function) or homozygous (50% reduced ine to methionine, and reduced s-adenosylmethionine (SAMe) concentrations. function) gene, your methylfolate requirement is higher. Reduced levels of methylfolate lead to decreased Normal Variants Found production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylMultiple have considered riboflavin and shown that the MTHFR 677that TTWhen genoMTRR studies MTRR attaches a methyl group tostatus B12 considered and variants here will slow theshown process. methionine (SAMe) concentrations. Multiple studies have riboflavin status and the MTHFR 677 homozygous genotype is associated with high homocysteine when riboflavin (B2) status is low. type is associated withand high homocysteine when can riboflavin A66G both MTR MTRR exist, dysfunction occur. (B2) status is low. Homocysteine is a non-protein amino acid that is created and recycled in the methylation cycle. Sluggish GG Sluggish Homocysteine is a non-proteinGIF-rs558660 amino acid that is created and recycled in the methylation cycle. enzymes in the cycle can cause elevated levels in the blood, which can cause inflammation in enzymes can cause elevated levels in the blood, which can cause inflammation in the blood TCN2in the cycle Transcobalamin II (TCN2, or holotranscobalamin when bound) transports B12 to vessels. the blood vessels. High homocysteine has been implicated in amyloid DNAaffect damage cancer, mitochondrial dysfuncC766G peripheral tissues. Variants in thisbuildup, gene may B12and transport. tion, cardiovascular disease, and apoptosis of neurons. Targeting the slow enzymes with methylfolate helps Normal Variants Found bypass it and can maintain normal levels ofin homocysteine. Homocysteine has been implicated amyloid buildup, DNA damage, mitochondrial dysfunction, cardiovascular disease, andsufficient apoptosis of neurons. theSAMe slow enzymes MAT1 helps produce SAMe. Variants Targeting may decrease productionwith and It isMAT1 important to consider riboflavin intake, PEMT, MTR/MTRR, BHMT and CBS activity to assess overall homomethylfolate increase helpsToo bypass it and can maintain normal levels of homocysteine. It is important the forlow magnesium. 8 B6, genes tested. cysteine metabolism. highneed or too levels of B12, folate or their co-factors may cause dysregulation of to consider riboflavin intake, PEMT, MTR/MTRR, BHMT and CBS activity to assess overall methyl donor activity. The amount of methylfolate used in studies toGT reduce homocysteine with MTHFR variMAT1-rs1819684 homocysteine metabolism. ants has been 400-800mcg, and should be used with B12, B2 and B6. MAT1-rs2993763 MAT1-rs4934028 MAT1-rs7081756 MAT1-rs756208 PEMT AG AG AG TT Variants in PEMT may increase the need for choline and increase the sensitivity to anticholinergic drugs. 3 genes tested. NUTRITION NUTRITION GENOME GENOME ALEX J. SWANSON | M.S. ALEX J. SWANSON | M.S. http://nutritiongenome.com http://nutritiongenome.com Strengthening Your Genome... This section will give you an overall summary of your strengths and weaknesses, and how to strengthen the “chinks” in your armor. You will be given the following based on your genetic results: - Your highest vitamin, mineral and compound needs -You will learn what foods, drinks, toxins and additives to minimize/avoid -Recommended routine blood work markers SAMPLE REPORT VITAMINS, MINERALS, AND OTHER COMPOUNDS VITAMINS, MINERALS, AND OTHER COMPOUNDS Your genetic report showed an increased need for the following based on the highest amounts of vitamins and minerals. These are based on foods with the highest levels of these nutrients and do not take into account any allergies beyond gluten and lacYour genetic report showed an increased need forfood the following based on the highest tose. amounts of vitamins and minerals. These are based on foods with the highest levels of these nutrients and do not take into account any food allergies beyond gluten and lactose. VITAMINS, MINERALS AND FOODS TO EMPHASIZE OTHER VITAMINS, COMPOUNDS MINERALS AND FOODS TO EMPHASIZE OTHER Calcium Gerolsteiner mineral water, spinach, kale, almonds, parsley, and grass-fed dairy COMPOUNDS Calcium B6 Gerolsteiner water, spinach, kale, almonds, parsley, grass-fed dairy Wild salmon,mineral wild cod, pistachios, avocados, spinach, Yukonand gold or red potatoes, cauliflower, Kombucha and unfiltered beer B6 Glycine Wild salmon, wild cod, pistachios, avocados, spinach, Yukon gold or red potatoes, cauliflower, Kombucha and unfiltered beerprotein Bone broth, chicken broth and grass-fed whey Glycine B12 Bone broth, chicken brothbeef, and grass-fed Pastured eggs, grass-fed grass-fed whey lamb, protein pastured pork, chicken, turkey and seafood B12 Pastured eggs, grass-fed beef, grass-fed lamb, pastured pork, chicken, turkey and seafood STRENGTHS WEAKNESSES STRENGTHS WEAKNESSES • Higher sensitivity to gluten • Increased need for B6 for healthy • Good protein and fat metabolism • Higher sensitivity to gluten neurotransmitters • Good folate absorption • Good protein and fat metabolism • Increased need for B6 for healthy • Increased antioxidant support neurotransmitters needed • Optimal hormone function • Good folate absorption • Increased antioxidant • Increased need for stresssupport relieving strategiesneeded for heart health ••Excellent liver detoxification Optimal hormone function • Increased need for stress relieving • Increased support needed for • Excellent liver detoxification strategies for heart health post-workout recovery • Increased support needed for post-workout recovery NUTRITION GENOME ALEX J. SWANSON | M.S. NUTRITION GENOME ALEX J. SWANSON | M.S. http://nutritiongenome.com