Download you can view a sample report here.

THE NUTRITION GENOME
REPORT PREVIEW
NUTRITION
GENOME
The Nutrition Genome
Report looks at over
200 genes...
The Nutrition Genome Report looks at over 200 genes
and is organized by the following order:
Your Final Results
Digestion
Methylation
Hormone Health
Neurotransmitters and Mental Health
Inflammation and Antioxidant Protection
Pharmacogenomics and Detoxification
DNA Damage, Protection, and Repair
Cardiovascular and Exercise Health
What to expect in
your report...
The introduction of your report will explain how to
read your genetic report, as well as a basic overview
of your analysis.
PATIENT OVERVIEW
YOUR ANALYSIS
PATIENT NAME: Your Name
DATE OF ANALYSIS: Today’s Date
NUTRITION
GENOME
ALEX J. SWANSON | M.S.
http://nutritiongenome.com
The Methylation
Cycle Analysis
Here is an example of the methylation section. You
are given the gene, the gene function, and your specific variants. The paragraphs are customized based on
your unique genotype.
METHYLATION CYCLE
B12, CALCIUM, LITHIUM, B6 & FOLATE:
Heart Health, Reproductive Health, Brain Health, Pregnancy
CHOLINE:
Liver & Brain Health, Gallbladder, Pregnancy
ZINC:
Mental Health, Skin Health, Immune Health
MAGNESIUM & VITAMIN C:
Heart Health, Adrenal Health, Mental Health
SAMPLE REPORT
GENE
FUNCTION
NUTRIENT
GENE
GENE RSID
NORMAL HETEROZYGOUS HOMOZYGOUS
GENE
GENE
HETEROHOMONORMAL
PEMT-rs4244593
TT
RSID
FUNCTION
ZYGOUS
ZYGOUS
PEMT-rs4646406
TT
The MTHFR
C677T
PEMT-rs7946
CT
GENE
MTHFR
GENE
GENE RSID
NORMAL HETEROZYGOUS HOMOZYGOUS
gene encodoes
NBPF3 has been associated with vitamin
NBPF3 C677T
MTHFR
AG
FUNCTION
C677TB6 levels.
theMTHFR gene to
NBPF3-rs4654748
-rs1801133
convert
folategene
into encodes
The MTHFR
C677T
the MTHFR gene to convert folate CC
into the active
MTHFR
the active form,
Betaine-homocysteine
methyltransferase
(BHMT)
catalyzes
the
remethylation
of the
form,
methylfolate.
Variants
in
this
gene
slow
down
enzymatic
function,
increasing
BHMT
C677T
methylfolate.
Varihomocysteine.
need
for folate and B2.
ants in this gene slow
MTHFR C677TBHMT-rs3797546
CT
AG
down enzymatic
rs1801133
function, incraeasing
CBS
The
Cystathione
Beta-Synthase
(CBS) enzyme
pulls homocysteine
hydrogen sulfide
MTHFR
A1298C
is involved
in converting
5-methylfolate
(5MTHF) tototetrahydrofolate
the
need
for
folate
MTHFR
191150T (H2S)
glutathione, requiring B6 and SAMe as a modulator.
(THF).and
Unlike
and B2.MTHFR C677T, the A1298C mutation does not lead to elevated
A1298C
Normal
Variants
Found
homocysteine levels unless
paired
with a heterozygous
MTHFR C677T.
MTHFR A1298C
CBS A360A-rs1801181
Normal Variants FoundAG
CBS C699T-rs234706
A protein encoded
by this gene is a transporter ofAG
folate and is involved in the
SLC19A1
regulation of intracellular concentrations of folate.
SLC19A1-rs1051266
FOL1
METHYLATION ANALYSIS
METHYLATION ANALYSIS
FOL genes code for folate receptors. 3 genes tested.
Folate-MTHFR 677
DHFR
CC
Normal Variants Found
Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to
metabolism.
Improves
MTHFR
C677T Gene Function:
Riboflavin
methylfolate.
A20965G
tetrahydrofolate
(THF) and
affect and
synthetic
folic acid
If you have
a heterozygous
MTHFR
677
(30%
reduced
function) antivirals,
or homozygous
Decreases
Gene
Function: PPI'S, birth
control
pills,
NSAIDs,
anticonvulsants,
antibiotics(50%
and acid
Normal
Variants
Found
blockers/antacids.
reduced function) gene, your methylfolate requirement is higher. Reduced levels of methyl-
MTR
MTR (methionine synthase) combines folate, methyl B12 and homocysteine into
folate lead to decreased production of neurotransmitters, reduced conversion of homocysteA2756G
Research:
If you methionine.
have a heterozygous MTHFR 677 (30% reduced function) or homozygous (50% reduced
ine to methionine, and reduced s-adenosylmethionine
(SAMe)
concentrations.
function) gene, your methylfolate requirement
is higher.
Reduced
levels of methylfolate lead to decreased
Normal
Variants
Found
production of neurotransmitters, reduced conversion of homocysteine to methionine, and reduced s-adenosylMultiple
have
considered
riboflavin
and
shown
that
the
MTHFR
677that
TTWhen
genoMTRR studies
MTRR
attaches
a methyl
group
tostatus
B12 considered
and
variants
here
will
slow
theshown
process.
methionine
(SAMe)
concentrations.
Multiple
studies
have
riboflavin
status
and
the
MTHFR
677
homozygous
genotype
is
associated
with
high
homocysteine
when
riboflavin
(B2)
status
is
low.
type
is associated
withand
high
homocysteine
when can
riboflavin
A66G
both MTR
MTRR
exist, dysfunction
occur. (B2) status is low. Homocysteine
is a non-protein amino acid that is created and recycled in the methylation cycle. Sluggish
GG Sluggish
Homocysteine is a non-proteinGIF-rs558660
amino acid that is created and recycled in the methylation cycle.
enzymes
in
the
cycle
can
cause
elevated
levels
in
the
blood,
which
can
cause
inflammation
in
enzymes
can cause elevated
levels
in the blood, which can
cause
inflammation
in the
blood
TCN2in the cycle
Transcobalamin
II (TCN2,
or holotranscobalamin
when
bound)
transports
B12
to vessels.
the
blood
vessels.
High
homocysteine
has been
implicated
in amyloid
DNAaffect
damage
cancer, mitochondrial dysfuncC766G
peripheral
tissues.
Variants
in thisbuildup,
gene may
B12and
transport.
tion, cardiovascular disease, and apoptosis of neurons. Targeting the slow enzymes with methylfolate helps
Normal
Variants
Found
bypass
it and can maintain
normal
levels ofin
homocysteine.
Homocysteine
has been
implicated
amyloid
buildup,
DNA damage, mitochondrial dysfunction, cardiovascular
disease,
andsufficient
apoptosis
of neurons.
theSAMe
slow enzymes
MAT1 helps
produce
SAMe.
Variants Targeting
may decrease
productionwith
and
It isMAT1
important to consider riboflavin intake, PEMT, MTR/MTRR, BHMT and CBS activity to assess overall homomethylfolate increase
helpsToo
bypass
it and
can
maintain
normal
levels
of homocysteine. It is important
the
forlow
magnesium.
8 B6,
genes
tested.
cysteine metabolism.
highneed
or too
levels of B12,
folate
or their co-factors may cause dysregulation of
to
consider
riboflavin
intake,
PEMT,
MTR/MTRR,
BHMT
and
CBS
activity to assess
overall
methyl donor activity. The amount
of methylfolate used in studies toGT
reduce homocysteine
with MTHFR
variMAT1-rs1819684
homocysteine
metabolism.
ants
has been 400-800mcg,
and should be used with B12, B2 and B6.
MAT1-rs2993763
MAT1-rs4934028
MAT1-rs7081756
MAT1-rs756208
PEMT
AG
AG
AG
TT
Variants in PEMT may increase the need for choline and increase the sensitivity to
anticholinergic drugs. 3 genes tested.
NUTRITION
NUTRITION
GENOME
GENOME
ALEX J. SWANSON | M.S.
ALEX
J. SWANSON | M.S.
http://nutritiongenome.com
http://nutritiongenome.com
Strengthening
Your Genome...
This section will give you an overall summary of your
strengths and weaknesses, and how to strengthen the
“chinks” in your armor.
You will be given the following based on your genetic
results:
- Your highest vitamin, mineral and compound needs
-You will learn what foods, drinks, toxins and additives to
minimize/avoid
-Recommended routine blood work markers
SAMPLE REPORT
VITAMINS, MINERALS, AND OTHER COMPOUNDS
VITAMINS,
MINERALS, AND OTHER COMPOUNDS
Your genetic report showed an increased need for the following based on the highest
amounts of vitamins and minerals. These are based on foods with the highest levels of
these
nutrients
and do
not take
into account
any
allergies beyond
gluten
and lacYour genetic
report
showed
an increased
need
forfood
the following
based on
the highest
tose.
amounts of vitamins and minerals. These are based on foods with the highest levels of
these nutrients and do not take into account any food allergies beyond gluten and lactose.
VITAMINS,
MINERALS AND
FOODS TO EMPHASIZE
OTHER
VITAMINS,
COMPOUNDS
MINERALS AND
FOODS TO EMPHASIZE
OTHER
Calcium
Gerolsteiner mineral water, spinach, kale, almonds, parsley, and grass-fed dairy
COMPOUNDS
Calcium
B6
Gerolsteiner
water,
spinach,
kale, almonds,
parsley,
grass-fed
dairy
Wild
salmon,mineral
wild cod,
pistachios,
avocados,
spinach,
Yukonand
gold
or red potatoes, cauliflower, Kombucha and unfiltered beer
B6
Glycine
Wild salmon, wild cod, pistachios, avocados, spinach, Yukon gold or red potatoes, cauliflower,
Kombucha
and
unfiltered
beerprotein
Bone
broth, chicken
broth and
grass-fed
whey
Glycine
B12
Bone
broth,
chicken
brothbeef,
and grass-fed
Pastured
eggs,
grass-fed
grass-fed whey
lamb, protein
pastured pork, chicken, turkey
and seafood
B12
Pastured eggs, grass-fed beef, grass-fed lamb, pastured pork, chicken, turkey
and seafood
STRENGTHS
WEAKNESSES
STRENGTHS
WEAKNESSES
• Higher sensitivity to gluten
• Increased need for B6 for healthy
• Good protein and fat metabolism
• Higher
sensitivity to gluten
neurotransmitters
• Good folate absorption
• Good protein and fat metabolism
• Increased
need
for B6 for
healthy
• Increased
antioxidant
support
neurotransmitters
needed
• Optimal hormone function
• Good folate absorption
• Increased
antioxidant
• Increased
need
for stresssupport
relieving
strategiesneeded
for heart health
••Excellent
liver detoxification
Optimal hormone
function
• Increased
need
for stress
relieving
• Increased
support
needed
for
• Excellent liver detoxification
strategies
for heart
health
post-workout
recovery
• Increased support needed for
post-workout recovery
NUTRITION
GENOME
ALEX J. SWANSON | M.S.
NUTRITION
GENOME
ALEX J. SWANSON | M.S.
http://nutritiongenome.com