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Transcript
BIOL 3301 GENETICS Date: Monday, March 10, 1.00-2.30 pm Subject: The structure and replication of DNA. Reading in ‘An introduction to genetic analysis’ (Griffiths et al., 7th edition) Chapter 8: The structure and replication of DNA. ________________________________________________________________________ Key concepts and keywords: DNA: the genetic material. transformation Griffith/ Avery, MacLeod, Mc Carty/ Hershey and Chase (8-1, 8-3) Structure of DNA. nucleotide, nucleoside, base (purine & pyrimidine) (8-4) Chargaff’s rules double helix: phosphate backbone, hydrogen bonds, antiparallel, A-DNA, B-DNA, ZDNA, major and minor grooves (8-5, 8-6, 8-8, 8-9) Replication of DNA. semiconservative (8-10) Meselson & Stahl experiment Mechanisms of DNA replication. DNA polymerases Origin and terminus of replication (8-22, 8-23) Priming DNA synthesis (8-20) Leading and lagging strand (8-28) Okazaki fragment (8-30) Replication at chromosome tips, telomerase (8-32) Helicases and topoisomerases Exonuclease editing: proofreading (8-38) Experimental applications of base-sequence complementarity ________________________________________________________________________ Homework: Problems 1, 12, 13 ________________________________________________________________________ Reading for next class (3-17) : Chapter 9: Genetics of DNA function.
