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DNA and Molecular Genetics Evidence DNA structure Transcription Life cycle Replication Translation Gene concept Uses Evidence Bacteria Smooth Smooth bacteria Smooth cause mouse die Rough bacteria Rough Heated Smooth Rough Heated Smooth no change Heat to 60oC bacteria died Heated Smooth Heated Rough Smooth Heated Smooth Rough Heated smooth bacteria mixed with rough can cause mouse dead Rough Some things transmit to rough. Life cycle of Bacteriophage ANIMATION DNA Structure Nucleic Acids Phosphate base Ribose Adenine Cytosine Purine Pyrimidine Guanine Thymine Nucleic Acid ATGC combination DNA Replication During cell division, DNA must reproduce itself, so that all genetic information can be transferred to daughter cells. There are three hypothesis about DNA replication. Experiment Replication mechanism ANIMATION Gene concept Gene is a sequence of DNA. Each chromosome contains a lot of gene. Each gene control a characteristic. So each chromosome may control a lot of gene. Transcription How do gene control characteristic? Gene is a sequence of DNA which contain genetic information. A messenger transports the information out the nucleus. The messenger is read by ribosome and transform to protein as building block of our body. The messenger is messenger RNA. ANIMATION How do mRNA work? Translation tRNA Translation Translation ANIMATION Code of codon Whole Process Use of DNA technology Funny Website