Download Mutations Foldable

Mutations Foldable
1. Fold 3 pieces of paper, so you have 5
layered flaps
2. Write “Mutations” on the top flap as a
title
On each flap write:
1.
2.
3.
4.
5.
What is a mutation?
Point Mutations
Chromosomal Mutations
Advantages/Disadvantages
Real Life Example
1. What is a mutation?
(Inside) On Top Half of 1st Flap write:
•
Mutations- any change in DNA that may
affect the expression of a gene
– Proteins that produced as a result of mutations:
1. may fail to function
2. may change the phenotype of an organism
•
Mutations can be caused by mutagens.
– Examples from the environment- UV light,
chemicals, radioactive substances, X-rays
(Inside) On Bottom Half of 1st Flap:
Glue in the following picture & Label the following:
1.
2.
3.
4.
5.
Strand D- DNA was mutated by UV light; circle the
5th base- it should be T but now is C
Strand H- mRNA is made from mutated DNA
template during transcription; circle the 5th base- it
should be A but now is G
Stand N- Polypeptide chain (amino acid sequence);
circle the 2nd amino acid (THIS IS THE WRONG
AMINO ACID!)
O- Mutation is seen here first; mutation causes no
color pigment to occur
Flowers have no color!
2. Point Mutations
(Inside) On Top Half of 2nd Flap write:
• Point Mutations- a change in a specific
base in the DNA that causes a “shift” in the
reading frame  causes a change in
codons
(Inside) On Bottom Half of 2nd Flap write:
TYPES
Glue in the following picture &
Label the following:
(1)
(2)
(3)
Circle the substitution that
has occurred; next to the
picture write: Substitutions
occur when one base is
changed
Circle the deletion that has
occurred ; next to the
picture write: Deletions
occur when one base is
removed or lost
Circle the insertion that has
occurred ; next to the
picture write: Insertions
occur when one base is
added to a sequence of
DNA
3. Chromosomal Mutations
(Inside) On Top Half of 3rd Flap write:
• Chromosomal Mutations- a change in a
specific segment of the DNA  both
positive and negative affects
– cause a protein to malfunction
– cause a different protein to be made
(Inside) On Bottom Half of 3rd Flap write:
TYPES
(1)
(2)
(3)
(4)
Glue in the following picture & Label the following:
Color the segment of DNA that has been deleted;
next to the picture write: Deletions occur when a
segment of DNA has been removed
Color the segment of DNA that has been inverted;
next to the picture write: Inversions occur when a
segment of DNA has been flipped
Color the segment of DNA that has been
translocated; next to the picture write:
Translocations occur when a segment of DNA has
moved to a different location on another
chromosome
Color the segment of DNA that has been duplicated;
next to the picture write: Duplications occur when
another copy of a segment of DNA is made
4. Advantages/Disadvantages
of Mutations
(Inside) On Top Half of 4th Flap write:
ADVANTAGES
- New forms of a trait
- Drug resistance
- Antibiotic resistance
(Inside) On Bottom Half of 4thFlap write:
DISADVANTAGES
- Absence of a trait
- Cancer
- Diseases/Genetic Disorders
- Sickle Cell Anemia
5. Mutations in the Human Body
Examples of Disease that cause mutations
Sickle Cell Anemia
Next to
picture:
Explain the
mutation