Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download PowerPoint
Document related concepts
Cell-free fetal DNA wikipedia , lookup
Biology and consumer behaviour wikipedia , lookup
DNA vaccination wikipedia , lookup
Gene nomenclature wikipedia , lookup
Minimal genome wikipedia , lookup
Molecular cloning wikipedia , lookup
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing wikipedia , lookup
Gene desert wikipedia , lookup
Gene expression programming wikipedia , lookup
Histone acetyltransferase wikipedia , lookup
Cre-Lox recombination wikipedia , lookup
Extrachromosomal DNA wikipedia , lookup
Gene therapy of the human retina wikipedia , lookup
Long non-coding RNA wikipedia , lookup
X-inactivation wikipedia , lookup
Genome evolution wikipedia , lookup
Non-coding DNA wikipedia , lookup
Genetic engineering wikipedia , lookup
Point mutation wikipedia , lookup
Genomic imprinting wikipedia , lookup
Gene therapy wikipedia , lookup
Epigenetics of depression wikipedia , lookup
Primary transcript wikipedia , lookup
Gene expression profiling wikipedia , lookup
Epigenetic clock wikipedia , lookup
Transgenerational epigenetic inheritance wikipedia , lookup
DNA methylation wikipedia , lookup
Genome (book) wikipedia , lookup
Bisulfite sequencing wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
Helitron (biology) wikipedia , lookup
Behavioral epigenetics wikipedia , lookup
History of genetic engineering wikipedia , lookup
Epigenetics wikipedia , lookup
Microevolution wikipedia , lookup
Oncogenomics wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Epigenetics of human development wikipedia , lookup
Designer baby wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Epigenetics of neurodegenerative diseases wikipedia , lookup
Polycomb Group Proteins and Cancer wikipedia , lookup
Epigenomics wikipedia , lookup
Cancer epigenetics wikipedia , lookup
Epigenetics of diabetes Type 2 wikipedia , lookup
Epigenetics in stem-cell differentiation wikipedia , lookup
Transcript
THERE ARE 3 MAIN EPIGENETIC MECHANISMS. THEY ARE… DNA METHYLATION HISTONE ACETYLATION AND NON-CODING RNA IN THE METHYLATION OF A TUMOR-SUPPRESSOR GENE… A methyl group attaches directly to the gene. The tumor-suppressor gene can’t be transcribed because the transcription complex can’t bind. With the tumorsuppressor gene inactivated, cell division isn’t regulated. Cancer cells are able to multiply. WHEN DNA HISTONES OF A TUMOR-SUPPRESSOR GENE ARE DEACETYLATED… An acetyl group is removed from the lysine of a histone tail. Chromatin, which was previously loose, is now tightly compacted. The tumor-suppressor gene cannot be transcribed. Cancer cells are able to multiply. WHEN MICRORNA PREVENTS TRANSLATION OF SPECIFIC GENES… It downregulates methyltransferases, preventing the methylation of tumor-suppressor genes. A decrease in microRNA allows methyltransferase to methylate DNA. Methylation of a tumorsuppressor gene allows for uncontrolled cell growth. Cancer cells are able to multiply. EPIGENETIC THERAPY Utilizes DNA methylation inhibitors to reverse DNA methylation in tumorsuppressor genes. Uses histone deacetylase (HDAC) inhibitors to prevent the deacetylation of histones bound to tumor suppressor genes. CONCLUSION
