* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Glossary AV 121017
DNA polymerase wikipedia , lookup
Genome evolution wikipedia , lookup
Cancer epigenetics wikipedia , lookup
Population genetics wikipedia , lookup
Genome (book) wikipedia , lookup
DNA sequencing wikipedia , lookup
Whole genome sequencing wikipedia , lookup
Human genetic variation wikipedia , lookup
Molecular Inversion Probe wikipedia , lookup
Zinc finger nuclease wikipedia , lookup
X-inactivation wikipedia , lookup
Genetic engineering wikipedia , lookup
Polymorphism (biology) wikipedia , lookup
DNA profiling wikipedia , lookup
DNA damage theory of aging wikipedia , lookup
DNA vaccination wikipedia , lookup
Neocentromere wikipedia , lookup
Primary transcript wikipedia , lookup
Metagenomics wikipedia , lookup
Comparative genomic hybridization wikipedia , lookup
Human genome wikipedia , lookup
Designer baby wikipedia , lookup
Gel electrophoresis of nucleic acids wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing wikipedia , lookup
United Kingdom National DNA Database wikipedia , lookup
Molecular cloning wikipedia , lookup
SNP genotyping wikipedia , lookup
Epigenomics wikipedia , lookup
Point mutation wikipedia , lookup
Nucleic acid double helix wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Dominance (genetics) wikipedia , lookup
Nucleic acid analogue wikipedia , lookup
Cre-Lox recombination wikipedia , lookup
Extrachromosomal DNA wikipedia , lookup
Genomic library wikipedia , lookup
Bisulfite sequencing wikipedia , lookup
Quantitative trait locus wikipedia , lookup
Cell-free fetal DNA wikipedia , lookup
Genealogical DNA test wikipedia , lookup
DNA supercoil wikipedia , lookup
Non-coding DNA wikipedia , lookup
Genome editing wikipedia , lookup
Deoxyribozyme wikipedia , lookup
History of genetic engineering wikipedia , lookup
Helitron (biology) wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
BRIEF GLOSSARY OF GENETIC TERMS Allele: Mbp Micro-satellite Mini-satellite Mutation NGS Phenotype Physical map Polymorphism QTL RFLP RNA SNP Synteny UTR VNTR One of several alternative forms of a DNA sequence at a specific chromosomal location (locus). At each autosomal chromosomal locus in a cell two alleles are present, one inherited from the mother, the other from the father DeoxyriboNucleic Acid - doublestrand A polymorphic DNA segment at a known chromosomal location. All exons from a genome together The most likely order of DNA segments on the chromosome based on analysis of co-segregation of DNA markers in pedigrees. The analysis of several hundreds of DNA markers (usually micro-satellites) which are more or less evenly spread over all of the chromosomes, in collections of related individuals to look for linkage with a phenotype. The combination of two alleles at a locus in an individual. Genome-Wide Association Study A series of alleles found at linked loci on a single chromosome (phase). Two identical alleles on a given locus Two different alleles at a given locus Identity by descent. The situation where alleles in two or more individuals are identical because of common ancestry. Identity by state. The situation where alleles in two or more individuals are identical due to coincidence or to common ancestry. kilo base pairs (1.103 bp). The tendency of DNA sequences to be inherited together as a consequence of their close proximity on a chromosome. Linkage Disequilibrium: non-random association of alleles at linked loci A unique chromosomal location defining the position of a particular DNA sequence. Logarithm of the odds; measure of statistical likelihood that a genetic marker is associated through physical linkage with a gene causing or contributing to a particular phenotype. Megabasepairs (1.106 bp). A locus consisting of tandemly repetitive sequence units the size of which is (arbitrarily) defined as 1-5 bp. A locus consisting of tandemly repetitive sequence units the size of which is (arbitrarily) defined as 6 bp or more. an alteration in the DNA sequence Next Generation Sequencing All physical and mental properties of an organism The order of DNA segments on a chromosome as determined by molecular analysis of (large) DNA segments. the existence of two or more alleles at a frequency of at least 1% in the population. Quantitative Trait Locus; a gene that influences quantitative variation in a trait Restriction Fragment Length Polymorphism RiboNucleic Acid - singlestrand Single Nucleotide Polymorphism The location of loci on the same individual chromosome Un-Translated Region (as in 3’UTR of a mRNA) Variable Number of Tandem Repeats; a polymorphic micro- or minisatellite WES Whole Exome Sequencing DNA DNA marker Exome Genetic map Genome search Genotype GWAS Haplotype Heterozygous Homozygous IBD IBS kbp Linkage LD Locus LOD score 2