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Download Leukaemia Section t(3;11)(p21;q23) Atlas of Genetics and Cytogenetics in Oncology and Haematology
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Transcript
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Leukaemia Section Short Communication t(3;11)(p21;q23) Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH) Published in Atlas Database: February 2000 Online updated version : http://AtlasGeneticsOncology.org/Anomalies/t0311ID1165.html DOI: 10.4267/2042/37594 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2000 Atlas of Genetics and Cytogenetics in Oncology and Haematology hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation. Clinics and pathology Disease AF3p21 Treatment related acute non lymphoblastic leukemia (tANLL). Location 3p21 Phenotype/cell stem origin M5b ANLL. Result of the chromosomal anomaly Epidemiology Only one case; a female patient aged 23 yrs and treated 9 years ago for T-ALL. Hybrid gene Prognosis Description Breakpoints of MLL between exons 9 and 10 and upstream of exon 1 of the AF3p21 gene. Unknown; likely to be poor, both as it carries a MLL rearrangements and as occurs in t-ANLL. Fusion protein Cytogenetics Description AT hooks and methyltransferase domains of MLL in the N-term fused to the proline-rich domain and nuclear localization signal of AF3p21. Cytogenetics morphological Sole anormaly. Genes involved and proteins References MLL Sano K, Hayakawa A, JinHua P. A novel sh3 protein encoded by the AF3p21 gene is fused to MLL in a therapy-related leukemia with t(3; 11)(p21;q23). Blood. 1999 ; 94 (numero Suppl 1). Location In 11q23 DNA/RNA 13-15 kb mRNA. Protein 431 kDa; contains two DNA binding motifs (a AT Atlas Genet Cytogenet Oncol Haematol. 2000; 4(1) This article should be referenced as such: Huret JL. t(3;11)(p21;q23). Atlas Genet Cytogenet Oncol Haematol. 2000; 4(1):40. 40
