Download Leukaemia Section t(10;11)(p12;q23) Atlas of Genetics and Cytogenetics in Oncology and Haematology

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
OPEN ACCESS JOURNAL AT INIST-CNRS
Leukaemia Section
Short Communication
t(10;11)(p12;q23)
Jean-Loup Huret
Genetics, Department of Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021
Poitiers, France
Published in Atlas Database: December 1997
Online version is available at: http://AtlasGeneticsOncology.org/Anomalies/t1011.html
DOI: 10.4267/2042/32072
This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence.
© 1997 Atlas of Genetics and Cytogenetics in Oncology and Haematology
MLL
Identity
Note: Not to be
t(10;11)(p14;q21).
confused
with
cases
Location: 11q23
DNA / RNA
21 exons, spanning over 100 kb; 13-15 kb mRNA.
Protein
431 kDa; contains two DNA binding motifs (a AT
hook, and Zinc fingers), a DNA methyl transferase
motif, a bromodomain; transcriptional regulatory
factor; nuclear localisation.
of
Clinics and pathology
Disease
ANLL.
Phenotype / cell stem origin
M5/M4; ALL at times, therapy related cases.
Epidemiology
From infants to adults.
Prognosis
Poor.
Results of the chromosomal
anomaly
Hybrid gene
Description
5’ MLL - 3’ AF10; variable breakpoints on both
chromosomes; the fusion transcript on chromosome 11
is the crucial one; MLL and AF10 are in opposite
transcriptional directions, which may be cause of the
complexity of the translocation.
Cytogenetics
Cytogenetics, morphological
A high diversity of reported breakpoints on
chromosome 10, from 10p11 to 10p15: remains to be
fully studied.
Fusion protein
inv(11)(q13q23) is frequently accompanying the
t(10;11); this is likely to be related to the transcription
directions of the two genes.
Description
N-term AT hook and DNA methyltransferase from
MLL fused to the leucine zipper C-term of AF10.
Expression localisation
Nuclear localisation.
Genes involved and Proteins
References
AF10
Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A,
Berger R, Young BD. The t(10;11) translocation in acute
myeloid leukemia (M5) consistently fuses the leucine zipper
motif of AF10 onto the HRX gene. Blood 1995 Sep
15;86(6):2073-6.
Additional anomalies
Location: 10p12
DNA / RNA
5’ telomeric → 3’ centromeric orientation.
Protein
Contains 3 Zn fingers and a leucine zipper; nuclear
localisation; transcription factor.
Atlas Genet Cytogenet Oncol Haematol. 1997;1(2)
This article should be referenced as such:
Huret JL. t(10;11)(p12;q23). Atlas Genet Cytogenet Oncol
Haematol.1997;1(2):101.
101