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Download Gene Section AF15q14 (ALL1 fused gene from 15q14) in Oncology and Haematology
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Transcript
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Short Communication AF15q14 (ALL1 fused gene from 15q14) Jean-Loup Huret, Christiane Charrin Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH), Service d'Hematologie, Hopital Edouard Herriot, Lyon, France (CC) Published in Atlas Database: March 2000 Online updated version : http://AtlasGeneticsOncology.org/Genes/AF15q14ID318.html DOI: 10.4267/2042/37605 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2000 Atlas of Genetics and Cytogenetics in Oncology and Haematology Homology Identity None so far. Location : 15q14 Implicated in DNA/RNA t(11;15)(q23;q14)/acute non lymphocytic leukemia (ANLL) --> MLL/AF15q14 Description Spans more than 35 kb; contains at least 10 exons; from centromere to telomere. Disease Only 1 case with the ascertainment of AF15q14 involvement. Transcription 5925 bp; open reading frame: 5499 bp. References Protein Hayette S, Tigaud I, Vanier A, Martel S, Corbo L, Charrin C, Beillard E, Deleage G, Magaud JP, Rimokh R. AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14). Oncogene. 2000 Sep 7;19(38):4446-50 Description 1833 amino acids; 206 kDa; nuclear localization domain in the c-term. Expression This article should be referenced as such: Ubiquitous in the foetus, nearly restricted to bone marrow, thymus, and testis in the adult. Huret JL, Charrin C. AF15q14 (ALL1 fused gene from 15q14). Atlas Genet Cytogenet Oncol Haematol. 2000; 4(2):50. Atlas Genet Cytogenet Oncol Haematol. 2000; 4(2) 50
