Download Gene Section AF15q14 (ALL1 fused gene from 15q14) in Oncology and Haematology

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Transcript
Atlas of Genetics and Cytogenetics
in Oncology and Haematology
OPEN ACCESS JOURNAL AT INIST-CNRS
Gene Section
Short Communication
AF15q14 (ALL1 fused gene from 15q14)
Jean-Loup Huret, Christiane Charrin
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
(JLH), Service d'Hematologie, Hopital Edouard Herriot, Lyon, France (CC)
Published in Atlas Database: March 2000
Online updated version : http://AtlasGeneticsOncology.org/Genes/AF15q14ID318.html
DOI: 10.4267/2042/37605
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2000 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Homology
Identity
None so far.
Location : 15q14
Implicated in
DNA/RNA
t(11;15)(q23;q14)/acute non lymphocytic
leukemia (ANLL) --> MLL/AF15q14
Description
Spans more than 35 kb; contains at least 10 exons; from
centromere to telomere.
Disease
Only 1 case with the ascertainment of AF15q14
involvement.
Transcription
5925 bp; open reading frame: 5499 bp.
References
Protein
Hayette S, Tigaud I, Vanier A, Martel S, Corbo L, Charrin C,
Beillard E, Deleage G, Magaud JP, Rimokh R. AF15q14, a
novel partner gene fused to the MLL gene in an acute myeloid
leukaemia with a t(11;15)(q23;q14). Oncogene. 2000 Sep
7;19(38):4446-50
Description
1833 amino acids; 206 kDa; nuclear localization
domain in the c-term.
Expression
This article should be referenced as such:
Ubiquitous in the foetus, nearly restricted to bone
marrow, thymus, and testis in the adult.
Huret JL, Charrin C. AF15q14 (ALL1 fused gene from 15q14).
Atlas Genet Cytogenet Oncol Haematol. 2000; 4(2):50.
Atlas Genet Cytogenet Oncol Haematol. 2000; 4(2)
50