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Download Gene Section 3p21) Atlas of Genetics and Cytogenetics
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Transcript
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Short Communication AF3p21 (ALL1 fused gene from chromosome 3p21) Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH) Published in Atlas Database: February 2000 Online updated version : http://AtlasGeneticsOncology.org/Genes/AF3p21ID228.html DOI: 10.4267/2042/37580 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2000 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity Implicated in HGNC (Hugo): NCKIPSD Location: 3p21 t(3;11)(p21;q23) --> AF3p21-MLL Disease Treatment related acute non lymphoblastic leukemia (tANLL). Hybrid/Mutated gene 5 prime MLL - 3 prime AF3q21. Abnormal protein AT hooks and methyltransferase domains of MLL in the N-term fused to the proline-rich domain and nuclear localization signal of AF3p21. Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. DNA/RNA References Description Sano K, Hayakawa A, Jin-Hua P. A novel sh3 protein encoded by the AF3p21 gene is fused to MLL in a therapy-related leukemia with t(3; 11)(p21;q23). Blood 1999;94 Suppl 1:Abst 221 2990 bp cDNA. Protein Description This article should be referenced as such: 722 amino acids; N-term SH3 domain, proline-rich domain, and a nuclear localization signal in C-term. Huret JL. AF3p21 (ALL1 fused gene from chromosome 3p21). Atlas Genet Cytogenet Oncol Haematol. 2000; 4(1):13. Expression Wide. Atlas Genet Cytogenet Oncol Haematol. 2000; 4(1) 13
