Streptokinase—a clinically useful thrombolytic
... streptokinase that are resistant to plasmin (Wu et al., 1998) and, therefore, have a longer functional half-life. The plasmin-resistant forms of streptokinase have been found to be as active as the native streptokinase. Recombinant streptokinase produced in the yeast Pichia pastoris is glycosylated, ...
... streptokinase that are resistant to plasmin (Wu et al., 1998) and, therefore, have a longer functional half-life. The plasmin-resistant forms of streptokinase have been found to be as active as the native streptokinase. Recombinant streptokinase produced in the yeast Pichia pastoris is glycosylated, ...
Using Distiller`s Dried Grains with Solubles in Poultry Diets
... Poultry Diets is Increasing DDGS produced by new Midwestern ethanol is higher in nutrient content and digestibility than DDGS from older plants Increased supply of DDGS has made it more economical to replace some of the corn, soybean meal, and dicalcium phosphate ...
... Poultry Diets is Increasing DDGS produced by new Midwestern ethanol is higher in nutrient content and digestibility than DDGS from older plants Increased supply of DDGS has made it more economical to replace some of the corn, soybean meal, and dicalcium phosphate ...
Iron Detoxification Properties of Escherichia coli
... and nucleation sites (1–5). These sites are important for rapid oxidation of Fe(II) to Fe(III) and its subsequent hydrolysis to form a mineral core on the inner surface of the protein. In the E. coli bacterioferritin, up to 12 protoporphyrin IX heme groups of unknown function bind between 2-fold sym ...
... and nucleation sites (1–5). These sites are important for rapid oxidation of Fe(II) to Fe(III) and its subsequent hydrolysis to form a mineral core on the inner surface of the protein. In the E. coli bacterioferritin, up to 12 protoporphyrin IX heme groups of unknown function bind between 2-fold sym ...
Full Text - Maastricht University Research Portal
... Disturbances of the haemostatic balance When the equilibrium between procoagulant and anticoagulant forces is disturbed, as a result of genetic defects or acquired factors, bleeding or thrombosis may occur. The most prevalent hereditary bleeding disorder is von Willebrand disease (vWD), which result ...
... Disturbances of the haemostatic balance When the equilibrium between procoagulant and anticoagulant forces is disturbed, as a result of genetic defects or acquired factors, bleeding or thrombosis may occur. The most prevalent hereditary bleeding disorder is von Willebrand disease (vWD), which result ...
Separate Sex-Influenced and Genetic Components
... loci should be over 99% WKY with any remaining SHR loci being a random mix and not necessarily those loci affecting blood pressure. Since sons were selected each generation, the Y chromosome is of SHR origin, although the pseudoautosomal region could contain loci of WKY origin. The second substrain, ...
... loci should be over 99% WKY with any remaining SHR loci being a random mix and not necessarily those loci affecting blood pressure. Since sons were selected each generation, the Y chromosome is of SHR origin, although the pseudoautosomal region could contain loci of WKY origin. The second substrain, ...
Pseudomonas aeruginosa cystic fibrosis clinical isolates produce
... the lung infections of cystic fibrosis (CF) patients is not well understood. Transcript-accumulation studies of bacterial populations in sputum reveal high levels of transcription of toxA, which encodes ETA, in some patients with CF. However, in general, tissue damage in the lungs of patients with C ...
... the lung infections of cystic fibrosis (CF) patients is not well understood. Transcript-accumulation studies of bacterial populations in sputum reveal high levels of transcription of toxA, which encodes ETA, in some patients with CF. However, in general, tissue damage in the lungs of patients with C ...
Cracking the Code: The Genetic Basis of Disease
... • For rare monogenic diseases, genetics plays a primary role • For common polygenic diseases, genetics and environment are both important • Genes for disease can be found through genetic association studies • Genetic studies have unveiled new biology and drug targets ...
... • For rare monogenic diseases, genetics plays a primary role • For common polygenic diseases, genetics and environment are both important • Genes for disease can be found through genetic association studies • Genetic studies have unveiled new biology and drug targets ...
Canine C-Reactive Protein
... leukocyte count. While CRP concentrations drop, WBC can remain high even after sutures are removed following surgery. - CRP vs Erythrocyte sedimentation rate (ESR) ESR is a crude test based on increased sedimentation of the erythrocytes (red blood cells). The increase of the ESR depends on an increa ...
... leukocyte count. While CRP concentrations drop, WBC can remain high even after sutures are removed following surgery. - CRP vs Erythrocyte sedimentation rate (ESR) ESR is a crude test based on increased sedimentation of the erythrocytes (red blood cells). The increase of the ESR depends on an increa ...
Measurement of Basal Levels of Factor VIIa in
... factor VI1 forms a bimolecular complex with its high affinity cell surface cofactor, tissue factor, which is presented on many cell types. Once bound to tissue factor, factor VI1 is rapidly converted to its activated two-chain form, factor VIIa. Precisely which protease is responsible for the conver ...
... factor VI1 forms a bimolecular complex with its high affinity cell surface cofactor, tissue factor, which is presented on many cell types. Once bound to tissue factor, factor VI1 is rapidly converted to its activated two-chain form, factor VIIa. Precisely which protease is responsible for the conver ...
(1 988-1 994) : novel major clones of se
... other patterns using a Summasketch I1 Plus digitizer tablet (Summagraphics) and MolMatch software (Ultra-Violet Products). This software computes the sizes of each of the DNA fragments from the pbp gene by comparing their mobility to those of reference size markers (pBR322 digested with HpaII). Frag ...
... other patterns using a Summasketch I1 Plus digitizer tablet (Summagraphics) and MolMatch software (Ultra-Violet Products). This software computes the sizes of each of the DNA fragments from the pbp gene by comparing their mobility to those of reference size markers (pBR322 digested with HpaII). Frag ...
ABO blood group system
... • Locus location of a gene on a chromosome • Allele variation of a gene that produces an alternative phenotype ...
... • Locus location of a gene on a chromosome • Allele variation of a gene that produces an alternative phenotype ...
BCL6 is regulated by p53 through a response element frequently
... reaction and is implicated in the pathogenesis of B-cell non-Hodgkin lymphoma (BNHL). BCL6 was originally identified by virtue of its involvement in 3q27 chromosomal translocations associated with 2 types of BNHL: diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).1-3 BCL6 is selecti ...
... reaction and is implicated in the pathogenesis of B-cell non-Hodgkin lymphoma (BNHL). BCL6 was originally identified by virtue of its involvement in 3q27 chromosomal translocations associated with 2 types of BNHL: diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL).1-3 BCL6 is selecti ...
Peripheral Circadian Clocks in the Vasculature
... component genes. Period 1 to 3 (Per) and Cryptochrome 1 to 2 (Cry) transcription/translation is induced in a rhythmic manner toward the beginning of the 12-hour light period. Rev Erb ␣ (Rev), an inhibitor of Bmal1 transcription, is similarly induced through Ebox motifs by the Clock:Bmal1 heterodimer ...
... component genes. Period 1 to 3 (Per) and Cryptochrome 1 to 2 (Cry) transcription/translation is induced in a rhythmic manner toward the beginning of the 12-hour light period. Rev Erb ␣ (Rev), an inhibitor of Bmal1 transcription, is similarly induced through Ebox motifs by the Clock:Bmal1 heterodimer ...
O A
... fibers and other carbohydrates), also the total phenolic compounds as the health promoting phytochemicals, in addition the total acidity found in these investigated samples. It could be observed that the moisture content was ranged between 80.18 to 82.21% in all tested samples. From the same Table, ...
... fibers and other carbohydrates), also the total phenolic compounds as the health promoting phytochemicals, in addition the total acidity found in these investigated samples. It could be observed that the moisture content was ranged between 80.18 to 82.21% in all tested samples. From the same Table, ...
HIF-2 regulates murine hematopoietic development
... We generated F1 hybrid mice by crossing 129⫹/⫺ female mice with C57⫹/⫺ male mice carrying a single mutant EPAS1 allele as described.47 Mice housed in a standard 12:12 light/dark cycle were fed ad lib with 4% fat-containing chow (mating pairs) or 11% fat-containing chow (pregnant females and newborn ...
... We generated F1 hybrid mice by crossing 129⫹/⫺ female mice with C57⫹/⫺ male mice carrying a single mutant EPAS1 allele as described.47 Mice housed in a standard 12:12 light/dark cycle were fed ad lib with 4% fat-containing chow (mating pairs) or 11% fat-containing chow (pregnant females and newborn ...
Molecular Genetics of von Willebrand Disease
... 2 pter.7*“’Localization studies using a cDNA probe from the midportion of vWF identified not only the authentic gene on chromosome 12 but a second sequence on chromosome 22.12 The latter has recently been localized to 22q11.22-ql 1.23.49The complete exon/intron structure of the vWF gene has been est ...
... 2 pter.7*“’Localization studies using a cDNA probe from the midportion of vWF identified not only the authentic gene on chromosome 12 but a second sequence on chromosome 22.12 The latter has recently been localized to 22q11.22-ql 1.23.49The complete exon/intron structure of the vWF gene has been est ...
Eliminating helper phage from phage display
... phage population produced by a single clone is phenotypically and genotypically homogenous, excluding the effects of proteolysis. In contrast, phagemid make recombinant displayed protein, but require the additional proteins provided by helper phage to create phage particles that display recombinant ...
... phage population produced by a single clone is phenotypically and genotypically homogenous, excluding the effects of proteolysis. In contrast, phagemid make recombinant displayed protein, but require the additional proteins provided by helper phage to create phage particles that display recombinant ...
Mutations of the Red Blood Cell Membrane Proteins
... with weakened SpD-SpT self-association.'.'2.2~ Several underlying DNA and primary structure defects have been subsequently detected in the vicinity of the abnormal cleavage site (Table 1). These mutations are designated according to size of the largest peptide derived from the abnormal a1 Below, we ...
... with weakened SpD-SpT self-association.'.'2.2~ Several underlying DNA and primary structure defects have been subsequently detected in the vicinity of the abnormal cleavage site (Table 1). These mutations are designated according to size of the largest peptide derived from the abnormal a1 Below, we ...
BMC Microbiology
... isolates [4]. Subsequently, multidrug-resistance phenotypes and extended-spectrum β-lactamase (ESBL) producers were identified for K. variicola during an intra-hospital outbreak at a pediatric hospital in Mexico [4,5]. Additionally, this species has been recently reported as a symbiotic nitrogen-fix ...
... isolates [4]. Subsequently, multidrug-resistance phenotypes and extended-spectrum β-lactamase (ESBL) producers were identified for K. variicola during an intra-hospital outbreak at a pediatric hospital in Mexico [4,5]. Additionally, this species has been recently reported as a symbiotic nitrogen-fix ...
IgG antibody profile to C-terminal region of Plasmodium vivax
... malaria endemic areas along Thai-Myanmar border in the west and Thai-Cambodia border in the east of Thailand was evaluated by enzyme-linked immunosorbent assay (ELISA). The antiPvMSP1-IgG antibody was observed in 110 individuals (55%). Among IgG responders, IgG1 coexpressed with IgG3 were the predom ...
... malaria endemic areas along Thai-Myanmar border in the west and Thai-Cambodia border in the east of Thailand was evaluated by enzyme-linked immunosorbent assay (ELISA). The antiPvMSP1-IgG antibody was observed in 110 individuals (55%). Among IgG responders, IgG1 coexpressed with IgG3 were the predom ...
Beta Thalassemia
... Bone marrow transplants have cured some cases of thalassemia. The success rate of it is as high as 95%, if there is no prior serious organ damage such as excess deposition of iron. ...
... Bone marrow transplants have cured some cases of thalassemia. The success rate of it is as high as 95%, if there is no prior serious organ damage such as excess deposition of iron. ...
where are we now?
... its origins in ’insulin resistance‘ or whether it is simply a euphemism for an underlying proinflammatory state is an ongoing debate. Certainly, we know that obesity by itself is one of the most important risk factors in the development of hypertension, but yet it remains difficult to assess the pre ...
... its origins in ’insulin resistance‘ or whether it is simply a euphemism for an underlying proinflammatory state is an ongoing debate. Certainly, we know that obesity by itself is one of the most important risk factors in the development of hypertension, but yet it remains difficult to assess the pre ...
Growth Hormone (GH) Insensitivity Syndrome with High Serum GH
... families showing GH insensitivity syndrome (GHIS). They showed severe postnatal growth failure with the typical phenotype of GH deficiency. The biochemical characteristics include a normal to high serum GH level and a low level of both serum insulin-like growth factor I (IGF-I) and IGFbinding protei ...
... families showing GH insensitivity syndrome (GHIS). They showed severe postnatal growth failure with the typical phenotype of GH deficiency. The biochemical characteristics include a normal to high serum GH level and a low level of both serum insulin-like growth factor I (IGF-I) and IGFbinding protei ...
Mitochondrial nitric oxide synthase
... mitochondrial consumption of O2 and Dj. These findings indicate that mtNOS continuously downregulates O2 consumption and Dj in intact rat liver mitochondria [15]. Although the occurrence and functions of mtNOS have been confirmed in many tissues, organs and cells, the isozyme of NOS that accounts fo ...
... mitochondrial consumption of O2 and Dj. These findings indicate that mtNOS continuously downregulates O2 consumption and Dj in intact rat liver mitochondria [15]. Although the occurrence and functions of mtNOS have been confirmed in many tissues, organs and cells, the isozyme of NOS that accounts fo ...
Repertoire Genetic Control of Human NK Cell
... combination of busulfan, cyclophosphamide, and etoposide, with or without fractionated total-body irradiation. Posttransplant graft-vs-host disease (GVHD), antiviral, and antibacterial prophylaxis were comparable (32– 35). Blood was drawn from donors and recipients before transplant and from patient ...
... combination of busulfan, cyclophosphamide, and etoposide, with or without fractionated total-body irradiation. Posttransplant graft-vs-host disease (GVHD), antiviral, and antibacterial prophylaxis were comparable (32– 35). Blood was drawn from donors and recipients before transplant and from patient ...
Complement component 4
Complement component 4 is a protein involved in the complement system.It is cleaved into proteins 4a and 4b; 4b can be further cleaved into 4c and 4d. C4a is an anaphylatoxin. C4b forms part of C3-convertase, in conjunction with 2a: C4b can bind CR1.