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Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Short Communication ATF1 (activating transcription factor 1) Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH) Published in Atlas Database: November 1999 Online updated version : http://AtlasGeneticsOncology.org/Genes/ATF1ID81.html DOI: 10.4267/2042/37553 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 1999 Atlas of Genetics and Cytogenetics in Oncology and Haematology Homology Identity Members of the CREB protein family. Other names: TREB36 HGNC (Hugo): ATF1 Location: 12q13 Implicated in Malignant melanoma of soft parts Disease Very rare neuroectodermal tumour. Prognosis Very poor. Cytogenetics Characterised by the translocation t(12;22)(q13;q12). Hybrid/Mutated gene 5' EWSR1- 3' ATF1. Abnormal protein The chimaeric protein is composed of the N-terminal domain of EWS linked to the bZIP domain of ATF-1. Oncogenesis Binds to ATF sites present in cAMP-responsive promoters via the ATF1 bZIP domain and activates transcription constitutively, dependent on the activation domain (EAD) present in EWSR1. Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. DNA/RNA Transcription 816 bp mRNA. Protein Description 271 amino acids; possess a basic motif and a leucinezipper; dimerisation with other ATF family members (e.g. ATF-1 homodimers and ATF-1/CREB heterodimers). References Yoshimura T, Fujisawa J, Yoshida M. Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J. 1990 Aug;9(8):2537-42 Localisation Nuclear. Rehfuss RP, Walton KM, Loriaux MM, Goodman RH. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J Biol Chem. 1991 Oct 5;266(28):18431-4 Function DNA binding protein, binds the consensus sequence: 5'GTGACGT(A/C)(A/G)-3'; cAMP-inducible transcription factor (cAMP-responsive enhancerbinding protein (CRE), like CREB. Atlas Genet Cytogenet Oncol Haematol. 1999; 3(4) Zucman J, Delattre O, Desmaze C, Epstein AL, Stenman G, Speleman F, Fletchers CD, Aurias A, Thomas G. EWS and 179 ATF1 (activating transcription factor 1) Huret JL ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Nat Genet. 1993 Aug;4(4):341-5 Pan S, Ming KY, Dunn TA, Li KK, Lee KA. The EWS/ATF1 fusion protein contains a dispersed activation domain that functions directly. Oncogene. 1998 Mar 26;16(12):1625-31 Guo B, Stein JL, van Wijnen AJ, Stein GS. ATF1 and CREB trans-activate a cell cycle regulated histone H4 gene at a distal nuclear matrix associated promoter element. Biochemistry. 1997 Nov 25;36(47):14447-55 This article should be referenced as such: Atlas Genet Cytogenet Oncol Haematol. 1999; 3(4) Huret JL. ATF1 (activating transcription factor 1). Atlas Genet Cytogenet Oncol Haematol. 1999; 3(4):179-180. 180