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Download Leukaemia Section t(2;21)(p11;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology
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Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Leukaemia Section Short Communication t(2;21)(p11;q22) Jean-Loup Huret Genetics, Dept Medical Information, UMR 8125 CNRS, University of Poitiers, CHU Poitiers Hospital, F86021 Poitiers, France (JLH) Published in Atlas Database: February 2003 Online updated version: http://AtlasGeneticsOncology.org/Anomalies/t0221p11q22ID1261.html DOI: 10.4267/2042/37962 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2003 Atlas of Genetics and Cytogenetics in Oncology and Haematology AML1 Clinics and pathology Location 21q22 DNA/RNA Transcription is from telomere to centromere Protein Contains a Runt domain and, in the C-term, a transactivation domain; forms heterodimers; widely expressed; nuclear localisation; transcription factor (activator) for various hematopoietic-specific genes. Disease M1 acute non lymhocytic leukemia (ANLL). Etiology No known prior exposure. Epidemiology Only one case to date, a 78 yr old male patient. Prognosis Death occurred during induction therapy. References Cytogenetics Richkind K, Hromas R, Lytle C, Crenshaw D, Velasco J, Roherty S, Srinivasiah J, Varella-Garcia M. Identification of two new translocations that disrupt the AML1 gene. Cancer Genet Cytogenet. 2000 Oct 15;122(2):141-3 Cytogenetics morphological Sole anomaly in this patient. Mathew S, Shurtleff SA, Raimondi SC. Novel cryptic, complex rearrangements involving ETV6-CBFA2 (TEL-AML1) genes identified by fluorescence in situ hybridization in pediatric patients with acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2001 Oct;32(2):188-93 Genes involved and proteins Note The gene in 2p11 is yet unknown, and, because cryptic t(12;21) ETV6 /AML1 are not rare, it is therefore uncertain whether this translocation involve a new AML1 partner. Atlas Genet Cytogenet Oncol Haematol. 2003; 7(2) This article should be referenced as such: Huret JL. t(2;21)(p11;q22). Atlas Genet Cytogenet Oncol Haematol. 2003; 7(2):117. 117
