* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Leukaemia Section t(19;21)(q13.4;q22) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Extrachromosomal DNA wikipedia , lookup
Genome (book) wikipedia , lookup
Epigenetics of neurodegenerative diseases wikipedia , lookup
Minimal genome wikipedia , lookup
Deoxyribozyme wikipedia , lookup
Gene expression profiling wikipedia , lookup
Nutriepigenomics wikipedia , lookup
Transcription factor wikipedia , lookup
Short interspersed nuclear elements (SINEs) wikipedia , lookup
Non-coding DNA wikipedia , lookup
History of genetic engineering wikipedia , lookup
Point mutation wikipedia , lookup
Designer baby wikipedia , lookup
Polycomb Group Proteins and Cancer wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Helitron (biology) wikipedia , lookup
Microevolution wikipedia , lookup
Medical genetics wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Epigenetics of human development wikipedia , lookup
Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Leukaemia Section Short Communication t(19;21)(q13.4;q22) Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France (JLH) Published in Atlas Database: February 2000 Online updated version : http://AtlasGeneticsOncology.org/Anomalies/t1921ID1182.html DOI: 10.4267/2042/37599 This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2000 Atlas of Genetics and Cytogenetics in Oncology and Haematology DNA/RNA Transcription is from telomere to centromere. Protein Contains a Runt domain and, in the C-term, a transactivation domain; forms heterodimers; widely expressed; nuclear localisation; transcription factor (activator) for various hematopoietic-specific genes. Clinics and pathology Disease Acute non lymphocytic leukemia (ANLL) secondary to toxic exposure. Note Only one case, but with features identical to 2 other cases: one case of t(1;21)(p36;q22), and one case of t(18;21)(q21;q22). Phenotype/cell stem origin Result of the chromosomal anomaly M2-ANLL Hybrid gene Etiology Description AMP-19 is fused to AML1 out of frame. About 50 years after radiation exposure from nuclear explosion. Fusion protein Clinics Description Truncated AML1 with the DNA binding domain, but not a transcriptional activation region. Oncogenesis Could function as a dominant negative inhibitor of normal AML1. Pancytopenia preceeded leukemia. Evolution Complete remission was obtained and the patient returned to the previous pancytopenia; subsequent relapse occurred. References Genes involved and proteins Hromas RA, Busse TM, Shopnick R, Jumean H, Bowers C, Richkind K. Cloning of an AML1 translocation in a novel syndrome of radiation-induced acute myeloid leukemia. Blood. 1999; 94 (suppl1). AMP19 Location 19q13.4 This article should be referenced as such: AML1 Huret JL. t(19;21)(q13.4;q22). Atlas Genet Cytogenet Oncol Haematol. 2000; 4(1):39. Location 21q22 Atlas Genet Cytogenet Oncol Haematol. 2000; 4(1) 39