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7.3 Gene Linkage and Mapping KEY CONCEPT Genes can be mapped to specific locations on chromosomes. 7.3 Gene Linkage and Mapping Chromosomal Theory of Inheritance-based on research of Thomas Morgan Hunt • Genes are located on chromosomes and the behavior of chromosomes during meiosis accounts for inheritance patterns. “Random Assortment” • Chromosomes exchange homologous genes during meiosis explains how linked genes can separate. 7.3 Gene Linkage and Mapping Linkage maps estimate distances between genes and show the relative locations of genes. Gene Linkage -the closer together two genes are, the more likely they will be inherited together. Linkage Maps –indicate the related to distances between genes by examining the cross-over frequencies. 7.3 Gene Linkage and Mapping • Cross-over frequencies can be converted into map units. – gene A and gene B cross over 6.0 percent of the time – gene B and gene C cross over 12.5 percent of the time – gene A and gene C cross over 18.5 percent of the time 7.3 Gene Linkage and Mapping Gene linkage was explained through fruit flies. Linked genes are not inherited together every time. Wild type Mutant