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Olfactory pathway Essam Eldin Abdel Hady Salama Sense of Smell The olfactory epithelium is the organ of smell. It covers the superior nasal conchae and roof of the nasal cavity. Olfactory receptor cells are bipolar neurons with radiating olfactory cilia. The Olfactory Pathway Outline of the Olfactory System The Olfactory Pathway Olfactory bulb Lateral olfactory stria Olfactory tract The Olfactory cortex The Olfactory Pathway Stimulated Receptors pass signal on to the Olfactory Nerves (I) which run through cribriform plate of ethmoid bone, attach to the olfactory bulbs on the inferior surface of the frontal lobe. Olfactory information reach the mitral cells in the olfactory bulbs, their axons form the olfactory tracts. Olfactory tracts on the inferior surface of the frontal lobe deflect laterally, in the lateral olfactory stria. The Olfactory Pathway Terminate into the primary olfactory area in the temporal lobe (uncus). Then to olfactory association cortex (anterior part of parahippocampal gyrus or entorinal area). The primary olfactory area and olfactory association cortex are referred to as the pyriform cortex. It is responsible for the appreciation of olfactory stimuli. The Olfactory Pathway (N.B) Chemicals must be dissolved in mucus for detection The olfactory pathway is consisting of a sequence of only two neurons There is no synapse in the thalamus for arriving information. The mitral cells send information to the hypothalamus, amygdala, and limbic system. Olfaction is a link between smell, memory, and emotion. In rodents it response to sex pheromones. Central Olfactory Pathways Olefactory Cortex Limbic System Thalamus Olfactory Bulb Olfactory Receptors Odorant Anthony J Greene 10 Central Olfactory Pathways Olefactory Cortex Limbic System Thalamus Olfactory Bulb Olfactory Receptors Odorant Anthony J Greene 11 Central Olefactory Pathways Olefactory Cortex Limbic System Thalamus Olfactory Bulb Olfactory Receptors Odorant Anthony J Greene 12 Central Olefactory Pathways Olefactory Cortex Limbic System Thalamus Olfactory Bulb Olfactory Receptors Odorant Anthony J Greene 13 Central Olefactory Pathways Olefactory Cortex Limbic System Thalamus Olfactory Bulb Olfactory Receptors Odorant Anthony J Greene 14 Central Olefactory Pathways Olefactory Cortex Limbic System Thalamus Olfactory Bulb Olfactory Receptors Odorant Anthony J Greene 15 Thank you