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Name __________________________________ Ms. Foglia Period _________ Date ______________________ AP: CHAPTER 16: THE MOLECULAR BASIS OF INHERITANCE 1. After Morgan and fellow scientists developed the Chromosomal Theory of Inheritance, the search was on for the chemical mechanism of inheritance. What are the two components of the chromosome? __________________________________________________________________________ 2. From initial logic, which component would be the most likely candidate for the genetic material and why? __________________________________________________________________________ __________________________________________________________________________ 3. What did Griffith, Avery, and others accomplish with bacteria? __________________________________________________________________________ __________________________________________________________________________ 4. Define transformation. _______________________________________________________ __________________________________________________________________________ 5. What did the experiments done by Alfred Hershey and Martha Chase show? __________________________________________________________________________ __________________________________________________________________________ 6. What are Chargaff’s rules? __________________________________________________________________________ __________________________________________________________________________ 7. If a species has 35% adenine in its DNA, determine the percent of the other three bases. __________________________________________________________________________ 1 of 4 2004-2005 Name __________________________________ Ms. Foglia 8. What was the role of Maurice Wilkins and Rosalind Franklin in determining the structure of DNA? __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ 9. Use the diagram to describe the structure of DNA. Include several comments. 10. What is the advantage of the double stranded aspect of the DNA? ____________________ __________________________________________________________________________ __________________________________________________________________________ 11. Which model of DNA replication is accepted? ____________________________________ __________________________________________________________________________ 2 of 4 2004-2005 Name __________________________________ Ms. Foglia 12. What happens at the DNA replication fork? __________________________________________________________________________ __________________________________________________________________________ 13. Make a list of the enzymes involved in replication and their role. __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ 14. Why does the DNA have to add nucleotides in the 5’ to 3’ direction? __________________________________________________________________________ __________________________________________________________________________ 15. Label the diagram of DNA replication. Include the directions and the terms. 3 of 4 2004-2005 Name __________________________________ Ms. Foglia 16. Describe the “priming of the DNA” before replication. _______________________________ __________________________________________________________________________ __________________________________________________________________________ 17. List some of the steps involved in DNA repair. ____________________________________ __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ 18. What is the problem that occurs at the ends of the chromosome during replication? __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ 19. What is a telomere and its role in cell division. ____________________________________ __________________________________________________________________________ __________________________________________________________________________ __________________________________________________________________________ 20. Why was there no selection pressure for prokaryotes to evolve a telomere-like solution on their chromosome? _________________________________________________________ __________________________________________________________________________ 21. Why is telomerase an active area in cancer research? _____________________________ __________________________________________________________________________ __________________________________________________________________________ 4 of 4 2004-2005