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Transcript
AP BIOLOGY CHAPTER 16 OUTLINE THE MOLECULAR BASIS OF INHERITANCE I. DNA AS THE GENETIC MATERIAL A. The search for the genetic material led to DNA: science as a process Proteins were thought to be the genetic material because: 1. Evidence that DNA can transform bacteria - Griffith's experiments - 2. Evidence that viral DNA can program cells - Hershey and Chase's experiments - 3. Additional evidence that DNA is the genetic material of cells a. Circumstantial evidence - b. Chargaff's experiments - B. Building a Structural Model of DNA: Scientific Inquiry 1. Rosalind Franklin's x-ray crystallography - 2. Watson and Crick's models - 3. Importance of the base-pairing rule - II. MANY PROTEINS WORK TOGETHER IN DNA REPLICATION AND REPAIR A. The Basic Principle: Base Pairing to a Template Strand 1. Template mechanism for DNA replication - 2. Semiconservative model - experimental evidence and conclusions - B. DNA Replication: A Closer Look – 1. Getting started: origins of replication - 2. Synthesizing aNew DNA Strand - 3. Antiparallel Elongation - 4. The DNA Replication Process - C. Proofreading and Repairing DNA -- D. Replicating the Ends of DNA Molecules – III. A Chromosome Consists of a DNA Molecule Packed Together With Proteins -
