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Name ______________________________ Class ___________________ Date __________________ Skills Worksheet Section 4-2C Section: How DNA Works 1. How much DNA does a single cell in your body hold? ____________________________________________________________________ UNRAVELING DNA _____ 2. What shape does DNA take in a cell that lacks a nucleus? a. a loose loop c. a tight chain b. a structure d. a protein _____ 3. What are the structures that strands of DNA are bundled into in a cell with a nucleus called? a. nucleotides c. chromosomes b. loose loops d. tight chains 4. A string of nucleotides that give the cell information about a certain trait is known as a(n) ______________________. 5. How many chromosomes does a human cell have before division? ____________________________________________________________________ 6. When a cell is ready to divide, how many chromatids make up a chromosome? ____________________________________________________________________ GENES AND PROTEINS 7. The ______________________ code is read like a book. 8. The alphabet of the code is made of the ______________________. 9. Groups of three bases are the codes for specific ______________________. 10. A long string of amino acids forms a(n) ______________________. 11. Instructions for making a protein are given by each ______________________. Original content Copyright © by Holt, Rinehart and Winston. Additions and changes to the original content are the responsibility of the instructor. Holt Science and Technology 4 Genes and DNA Name ______________________________ Class ___________________ Date __________________ Directed Reading A continued 12. List two examples of things proteins help determine about you. a. ___________________________________________________________________ b. ___________________________________________________________________ 13. Several forms of RNA or ______________________ help change DNA code into proteins. 14. Because it is so similar to ______________________, RNA can serve as a temporary copy of a DNA sequence. 15. The “factory” that assembles proteins is known as a(n) ______________________. 16. A mirror-like copy of DNA called ______________________ moves from the nucleus to the ribosome. 17. Another form of RNA called ______________________ matches amino acids with the bases on the messenger RNA. Put the following steps in making a protein in order by putting a number in the space provided: 1 for step 1, 2 for step 2, etc. _____ 18. The RNA copy is fed through the ribosome. _____ 19. Transfer RNA molecules deliver amino acids to the ribosome. _____ 20. Transfer RNA molecules pick up amino acids from the cytoplasm. _____ 21. The amino acids are joined to make a protein. _____ 22. A mirrorlike copy of the gene is made of RNA. Original content Copyright © by Holt, Rinehart and Winston. Additions and changes to the original content are the responsibility of the instructor. Holt Science and Technology 5 Genes and DNA Name ______________________________ Class ___________________ Date __________________ Directed Reading A continued CHANGES IN GENES 23. Changes in the number, type, or order of bases on a piece of DNA are known as ______________________. Match the correct definition with the correct term. Write the letter in the space provided. _____ 24. A base pair is added. a. substitution _____ 25. A base pair is replaced. b. insertion _____ 26. A base pair is removed. c. deletion 27. Physical or chemical agents known as ______________________ can cause mutations in DNA. 28. List two examples of mutagens. a. ___________________________________________________________________ b. ___________________________________________________________________ AN EXAMPLE OF A SUBSTITUTION _____ 29. Sickle cell disease is caused by a(n) a. substitution mutation. c. insertion mutation. b. deletion mutation. d. blood vessel mutation. USES OF GENETIC KNOWLEDGE _____ 30. The manipulation of individual genes within organisms by scientists is called a. mutation. c. genetic property. b. drug enhancement. d. genetic engineering. 31. List two possible uses of genetic engineering. ____________________________________________________________________ ____________________________________________________________________ 32. Because DNA is unique, DNA ______________________ can identify the unique patterns in an individual’s DNA and help solve crimes. 33. Only identical twins have truly identical ______________________. 34. A scientifically created organism that has an exact copy of another organism’s genes is a(n) ______________________. Original content Copyright © by Holt, Rinehart and Winston. Additions and changes to the original content are the responsibility of the instructor. Holt Science and Technology 6 Genes and DNA Name ______________________________ Class ___________________ Date __________________ Assessment Section 4-2C Quiz Section: How DNA Works Match the correct description with the correct term. Write the letter in the space provided. _____ 1. ribonucleic acid that copies DNA and goes to the ribosome _____ 2. the cell organelle where protein is synthesized _____ 3. a type of RNA that delivers amino acids to make a protein a. mutation b. ribosome c. messenger RNA d. transfer RNA _____ 4. a change in DNA sequence that can be harmful, helpful or make no difference In the space provided, write the letter of the term or phrase that best completes each statement or best answers each question. _____ 5. A string of nucleotides that has instructions for a certain trait is a a. cell. c. gene. b. ribonucleic acid. d. chromosome. _____ 6. As messenger RNA is fed through the ribosome it is matched with a. DNA. c. cells. b. transfer RNA. d. proteins. _____ 7. Three bases code for one a. cell. b. DNA. c. protein. d. amino acid. _____ 8. In what type of mutation is one base left out? a. substitution c. insertion b. deletion d. cell _____ 9. A tobacco plant with a firefly gene that makes it glow is an example of a. DNA fingerprinting. c. protein science. b. genetic engineering. d. firefly breeding. _____ 10. Which best expresses the relationship between genes and DNA? a. Genes contain DNA. c. Both contain chromosomes. b. DNA destroys genes. d. They are unrelated. Original content Copyright © by Holt, Rinehart and Winston. Additions and changes to the original content are the responsibility of the instructor. Holt Science and Technology 7 Genes and DNA