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Dr Alastair Fleming Short CV 1997 PhD at Heriot Watt University, Edinburgh, Scotland, UK 1997-2004 post-doc with Sari Pennings, Genes & Development Group, University of Edinburgh, Scotland, UK 2004-2007 post-doc with Mary Ann Osley, University of New Mexico, Albuquerque, NM, USA 2007-2009 Since 2009 post-doc with Bob White, Beatson Institute, Glasgow, Scotland, UK Lecturer in Microbiology, Department of Microbiology Trinity College Dublin, Ireland Epigenetic regulation of gene transcription. Publications My research uses the budding yeast, Saccharomyces cerevisiae as a model organism in which to study the role of chromatin during gene transcription. Shieh GS, Pan CH, Wu JH, Sun YJ, Wang CC, Hsiao WC, Lin CY, Tung L, Chang TH, Fleming AB, Hillyer C, Lo YC, Berger SL, Osley MA, Kao CF. H2B ubiquitylation marks exon-intron structure in budding yeast (2011) . BMC Genomics. 12: 627-637 The fundamental subunit of chromatin is the nucleosome, which consists of DNA wrapped around an octamer of four core histone proteins (H2A, H2B, H3 and H4). Chromatin packages DNA within the cell and is repressive to any process which requires access to the DNA including DNA repair, replication, recombination and gene transcription. Understanding how these processes occur in the context of chromatin is important since defective chromatin has been associated with developmental disorders and diseases such as cancer. Barski A, Chepelev I, Liko D, Cuddapah S, Fleming AB, Birch J, Cui K, White RJ, Zhao K. Pol II and associated epigenetic marks are present at Pol III genes (2010). Nat Struct Mol Biol. 17:629-34 By combining yeast genetics with chromatin analytical techniques, my research focuses on how the cell overcomes chromatin structure to allow access to the underlying DNA and enable normal cellular function. Fleming AB, Kao CF, Hillyer C, Pikaart M, Osley MA. H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation (2008). Mol Cell. 31: 56-66 Many of the factors involved in ‘remodelling’ the chromatin are evolutionary conserved. Hence, study of chromatin in yeast offers an excellent model system to gain insight into the role of chromatin in mammalian cells. Address Current research areas include: Investigation of chromatin remodelling during transcription initiation and elongation. Using yeast as a model organism to study cellular aging. Department of Microbiology Moyne Institute Trinity College Dublin, Ireland [email protected]