Download 650 BIOLCHEM Fall 2016 Course Announcement

COURSE ANNOUNCEMENT – FALL 2016
Biological Chemistry 650 - Eukaryotic Gene Expression
Lectures: Mon 10 am – 12 noon in 4560C MSRB II
Drs Dan Bochar, Yali Dou, Raymond Trievel, and Tom Kerppola (course director)
Biological Chemistry 650 focuses on in-depth discussion of high impact topics in selected
areas. The course seeks to develop the students’ understanding of recent progress in the
investigation of gene expression that is based on advances in biochemical, structural, molecular,
cellular and genomic approaches. The lectures are designed to update and to complement
survey courses by focusing on cutting edge discoveries and on their impact on potential future
directions of the field. The instructors make extensive use of examples from original research
articles, which are assigned reading in preparation for each class. To integrate their learning
throughout the semester, each student prepares a critique of an original research paper
selected from a list of papers recommended by the instructors. For more information, please
see course pages on Canvas (https://umich.instructure.com/courses/110853).
Sep. 12
Introduction/Core transcription factors (Kerppola/Bochar)
Sep. 19
Transcription initiation (Bochar)
Sep. 26
RNA-Pol II structure/elongation (Trievel)
Oct. 3
Higher order chromatin structures and chromatin remodeling (Bochar)
Oct. 10
Chromatin modifications (Dou)
Oct. 24
Chromatin modifying enzymes (Dou)
- deadline to select a paper for critical review
Oct. 31
Chromatin binding proteins (Dou)
Nov. 7
Transcription silencing and small RNAs (Dou)
Nov. 14
DNA methylation (Dou)
Nov. 21
From the genome to the transcriptome (Kerppola)
- deadline for polished draft of critical review
Nov. 28
Transcription regulatory elements and proteins (Kerppola)
Dec. 5
Transcription factor interactions and combinatorial regulation (Kerppola)
Dec. 12
Spatial organization of the nucleus and of the genome (Kerppola)
- deadline for final critical review