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Transcript
Using bioinformatics for better understanding of genes Becky Seipelt Karla Marriott Arlin Toro Vilma Martinez Roger Lui http://artedi.ebc.uu.se/course/BioInfo-10p-2006/projects/katarzyna/bioinformatics.jpg DNA Promoters Gene finding Variation Probability DOGMA 1. Gene finding RNA PROTEIN Transcription Splicing Editing Modifications Human Gene Variation Translation Editing Modifications Structure Complexes Function phenotype Structure Complexes Ideas A FEW Resources TRANSLATE 2. Case study using a normal and a known mutant gene Proposed activities Becky Seipelt, Middle Tennessee State University [email protected] •Honors Genetics (BIOL3250H) •2 blocks of 3 hours •Sophomore-seniors, mostly sophomores •Transcription and translation “learned” at least twice, perhaps more •Goals: •deeper understanding of processes and regulation •more engaged students • Active learning activity – Perhaps animation comparison • Give a small sequence file with 2-5 genes within. • Ask students to figure out how the cell “knows” where a gene is, i.e., where to start and stop transcription, and where to start and stop translation. • Introduce ‘gene finding’ algorithms for comparison (DOGMA) • Ask students to compare how “we” and nature differ? Lab exercise-Mitochondrial DNA Analysis http://www.edvotek.com/images/332.jpg Students will use DOGMA to identify genes that they amplify with PCR Working with the Sequence Blast and other analysis evolutionary problems How this project using DOGMA will help me teaching my genetics course The next time I teach the part of genomes and proteomes in my genetics course, in the explanation of comparative genomics, I can show similarities between different genomes and introduce them the evolutionary relationships between organisms of different species and the information that some species are more related than others. Computational and systems biology 7-week course. For comp. bio. part, either do sequence alignment problem if more math majors OR bioinformatics using data and software available on the web like what I have learned in this conference. • Development of new course targeting seniors and juniors • Involves lecture and laboratory • Research- DNA sequencing, translation and transcription to protein • Using software such as DOGMA, Translate, BLAST
