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Transcript
Ubiquitin By Mr. Szerminski Sample 4U CCT Topics to be discussed • General info: - it is a regulatory protein that has been found in almost all tissues of eukaryotes - one of its functions: it directs protein recycling - can attach to proteins and label them for destruction. - discovery won the Nobel Prize for chemistry in 2004 • A specific journal article about new research: Current Alzheimer Research, 2010, 7, 549-555 General Info • • • • • protein consists of 76 amino acids molecular mass of about 8.5 kDa (8 500 g/mol) key features: C-terminal tail and 7 lysine residues. human and yeast ubiquitin share 96% sequence identity one-letter code (lysine residues in bold): How it Works • Works by protein post-translational modification (PTM) in which the carboxylic acid of the terminal glycine from the di-glycine motif forms an amide bond to the epsilon amine of the lysine in the modified protein. From SCH4U organic unit… Current Research a.k.a. why is this exciting? Subtle and complex actions… Data from my paper Result Analysis (Conclusions) In simple language: Our (humanity’s) understanding the ubiquitin system is still in its infancy. Controlling Ubiquitin
