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How do cells deal with substances that are too large to pass through the cell membrane? Biology Unit V - Regulation Endocytosis Cells ingest large particles How Does This Happen? These external materials are enclosed by a portion of the cell, which folds into itself and forms a pouch The pouch pinches off from the cell membrane and becomes a membranebound organelle called a vesicle Endocytosis Exocytosis Vesicles in the cytoplasm fuse with the cell membrane and release their contents into the cell’s external environment Exocytosis Endocytosis & Exocytosis