BOOK_1_MCQs - WordPress.com
... Correct Ans. (a) 18. The word malaria has been derived from the combination of two words which are: a. Latin b. Italian c. Greek d. Arabic Correct Ans. (b) 19. Which one of the following best describes the scientific method? a. Doing experiments in laboratories b. Collecting all known facts on a ...
... Correct Ans. (a) 18. The word malaria has been derived from the combination of two words which are: a. Latin b. Italian c. Greek d. Arabic Correct Ans. (b) 19. Which one of the following best describes the scientific method? a. Doing experiments in laboratories b. Collecting all known facts on a ...
Melatonin: Buffering the Immune System
... production and circadian and seasonal adjustments in the immune system has been widely reported; this is extensively reviewed in [14,18]. The pineal gland is also an immune target. Interferon-gamma (IFN-γ) was shown to increase the production of melatonin from in vitro-cultured rat pineal glands [19 ...
... production and circadian and seasonal adjustments in the immune system has been widely reported; this is extensively reviewed in [14,18]. The pineal gland is also an immune target. Interferon-gamma (IFN-γ) was shown to increase the production of melatonin from in vitro-cultured rat pineal glands [19 ...
Reducing Ryanodine Receptor Open Probability as a Means to
... or abolished the diastolic Ca2⫹ release. This was accompanied by an increase in the amplitude of the systolic Ca2⫹ transient. Cellular Ca2⫹ flux balance was investigated by integrating Ca2⫹ entry (on the L-type Ca2⫹ current) and efflux (on Na–Ca2⫹ exchange). Isoproterenol increased Ca2⫹ influx but f ...
... or abolished the diastolic Ca2⫹ release. This was accompanied by an increase in the amplitude of the systolic Ca2⫹ transient. Cellular Ca2⫹ flux balance was investigated by integrating Ca2⫹ entry (on the L-type Ca2⫹ current) and efflux (on Na–Ca2⫹ exchange). Isoproterenol increased Ca2⫹ influx but f ...
Medical Applications and Toxicities of Gallium Compounds
... non-Hodgkin’s lymphoma and bladder cancer. At least 4 separate clinical trials have demonstrated the anti-lymphoma activity of gallium nitrate administered as a single agent [24-27], while 3 additional trials have used it in combination with other antineoplastic agents to improve treatment outcome [ ...
... non-Hodgkin’s lymphoma and bladder cancer. At least 4 separate clinical trials have demonstrated the anti-lymphoma activity of gallium nitrate administered as a single agent [24-27], while 3 additional trials have used it in combination with other antineoplastic agents to improve treatment outcome [ ...
Modelling and treating dysregulated fibrosis in primary open angle
... A primary risk factor for Primary Open Angle Glaucoma is elevated intraocular pressure induced by reduced outflow of aqueous humour through the trabecular meshwork due to fibrosis, which causes retinal ganglion cell death and loss of vision. This study aimed to: 1), create a rodent model of increase ...
... A primary risk factor for Primary Open Angle Glaucoma is elevated intraocular pressure induced by reduced outflow of aqueous humour through the trabecular meshwork due to fibrosis, which causes retinal ganglion cell death and loss of vision. This study aimed to: 1), create a rodent model of increase ...
89 calcium handling by the mammalian kidney
... Micropuncture studies have shown that approximately 55% of the filtered load of Ca2+ is reabsorbed along the proximal convoluted tubule and an additional 10% is reabsorbed in the proximal straight tubule (Suki, 1979; Suki and Rouse, 1992; Costanzo and Windhager, 1992). Passive driving forces are the ...
... Micropuncture studies have shown that approximately 55% of the filtered load of Ca2+ is reabsorbed along the proximal convoluted tubule and an additional 10% is reabsorbed in the proximal straight tubule (Suki, 1979; Suki and Rouse, 1992; Costanzo and Windhager, 1992). Passive driving forces are the ...
Endocytosis, Recycling, and Regulated Exocytosis of Glucose
... method is that GLUT4 molecules are sparsely labeled and imaged for only 10 s,46 such that the slow recycling of GLUT4 may not be readily observed. The static behavior of GLUT4 was also proposed for the clone of L6 muscle cells transiently expressing human HA-tagged GLUT4 by retroviral infection base ...
... method is that GLUT4 molecules are sparsely labeled and imaged for only 10 s,46 such that the slow recycling of GLUT4 may not be readily observed. The static behavior of GLUT4 was also proposed for the clone of L6 muscle cells transiently expressing human HA-tagged GLUT4 by retroviral infection base ...
Auxin transport routes in plant development
... The plant hormone auxin (the predominant form of which is indole3-acetic acid; IAA) is a major coordinating signal in the regulation of plant development. Many aspects of auxin action depend on its differential distribution within plant tissues, where it forms local maxima or gradients between cells ...
... The plant hormone auxin (the predominant form of which is indole3-acetic acid; IAA) is a major coordinating signal in the regulation of plant development. Many aspects of auxin action depend on its differential distribution within plant tissues, where it forms local maxima or gradients between cells ...
Calcium and Plant Development - Labs
... ( 1 95) may also provide a store of Ca2+ that can be released either through the direct action of the primary stimulus , e.g. light ( 1 95) , or indirectly through Ca2+ -induced Ca2+ release (6 1 ) . The result is an increase in the intracellular [Ca2+] from approximately 0 . 1 j.LM to 1 - 1 0 j.LM, ...
... ( 1 95) may also provide a store of Ca2+ that can be released either through the direct action of the primary stimulus , e.g. light ( 1 95) , or indirectly through Ca2+ -induced Ca2+ release (6 1 ) . The result is an increase in the intracellular [Ca2+] from approximately 0 . 1 j.LM to 1 - 1 0 j.LM, ...
store-operated calcium channels
... depletion of an intracellular Ca2⫹ pool and importantly that IP3 and TG had nonadditive effects, suggesting that they activate the same Ca2⫹ influx pathway. It soon became evident that the Ca2⫹ entry induced by TCR agonists and SERCA inhibitors shared key properties, suggesting that the currents in ...
... depletion of an intracellular Ca2⫹ pool and importantly that IP3 and TG had nonadditive effects, suggesting that they activate the same Ca2⫹ influx pathway. It soon became evident that the Ca2⫹ entry induced by TCR agonists and SERCA inhibitors shared key properties, suggesting that the currents in ...
2004__MORRIS_et_al_Transpor... - Institute of Experimental Botany
... Auxin transport factors that influence phloem translocation (58). This makes the phloem an unlikely route for the transmission of a signal molecule involved in the finetuning of growth and development. Nevertheless, significant quantities of IAA occur in phloem sap and it is clear that the total am ...
... Auxin transport factors that influence phloem translocation (58). This makes the phloem an unlikely route for the transmission of a signal molecule involved in the finetuning of growth and development. Nevertheless, significant quantities of IAA occur in phloem sap and it is clear that the total am ...
PDF - Blood Journal
... In HEK293 cells transfected with normal ␣IIb and 3, pro-␣IIb was observed in immunoprecipitates obtained immediately after the pulse was initiated (0 hour; Figure 1A); peak pro-␣IIb intensity was observed at 2 hours, and then the amount of pro-␣IIb decreased with a half-life (t1/2) of 5 plus or min ...
... In HEK293 cells transfected with normal ␣IIb and 3, pro-␣IIb was observed in immunoprecipitates obtained immediately after the pulse was initiated (0 hour; Figure 1A); peak pro-␣IIb intensity was observed at 2 hours, and then the amount of pro-␣IIb decreased with a half-life (t1/2) of 5 plus or min ...
Sample pages 1 PDF
... found on organelles and vesicles, preferentially on chloroplasts at cell apex of growing conical tip in Acetabularia [107]. The organelles and vesicles transport by plant myosins is documented in detail in the Chapter. In this Chapter, we focus mainly on the biochemical and biophysical properties an ...
... found on organelles and vesicles, preferentially on chloroplasts at cell apex of growing conical tip in Acetabularia [107]. The organelles and vesicles transport by plant myosins is documented in detail in the Chapter. In this Chapter, we focus mainly on the biochemical and biophysical properties an ...
Vitreous and Developmental Vitreoretinopathies
... breaks. The interface between vitreous and retina consists of a complex formed by the posterior vitreous cortex and the internal limiting lamina (ILL), which includes the basal lamina of Müller cells (62,63) (Fig. 3.6) (see also Chapter 4). The ILL is composed of type IV collagen closely associated ...
... breaks. The interface between vitreous and retina consists of a complex formed by the posterior vitreous cortex and the internal limiting lamina (ILL), which includes the basal lamina of Müller cells (62,63) (Fig. 3.6) (see also Chapter 4). The ILL is composed of type IV collagen closely associated ...
Hypericin - The Facts About a Controversial Agent
... emission maximums of about 600 nm (Fig. 2). Hypericin is soluble in biological media, which is made possible by complex formation of hypericin with biological macromolecules [3] (e.g. DNA, human serum albumin and other plasma proteins, membrane fragments and cellular compounds.) These properties are ...
... emission maximums of about 600 nm (Fig. 2). Hypericin is soluble in biological media, which is made possible by complex formation of hypericin with biological macromolecules [3] (e.g. DNA, human serum albumin and other plasma proteins, membrane fragments and cellular compounds.) These properties are ...
Microtubule Reconfiguration during Axonal Retraction Induced by
... g of streptomycin per milliliter (Sigma), 0.6% methylcellulose (Dow Chemical, Midland, M I), 10% FBS, and 25 ng /ml nerve growth factor (Upstate Biotechnology, Lake Placid, N Y). C ells were plated onto prephotoetched glass coverslips (Bellco Glass, Vineland, NJ), which had been attached to the bot ...
... g of streptomycin per milliliter (Sigma), 0.6% methylcellulose (Dow Chemical, Midland, M I), 10% FBS, and 25 ng /ml nerve growth factor (Upstate Biotechnology, Lake Placid, N Y). C ells were plated onto prephotoetched glass coverslips (Bellco Glass, Vineland, NJ), which had been attached to the bot ...
Bovine pneumonic pasteurellosis, more commonly known as
... 1. The CD18 signal peptide analog P1 (aa 1-20) and P5 (aa 5-24) inhibit Lkt-induced cytolysis of BL3 cells………………………………………57 2. N- and C-terminal truncations of peptide P5 identify aa 5-17 as the Lkt-binding domain on bovine CD18………………………………….....59 3. Inhibition of Lkt-induced cytolysis of ruminant ...
... 1. The CD18 signal peptide analog P1 (aa 1-20) and P5 (aa 5-24) inhibit Lkt-induced cytolysis of BL3 cells………………………………………57 2. N- and C-terminal truncations of peptide P5 identify aa 5-17 as the Lkt-binding domain on bovine CD18………………………………….....59 3. Inhibition of Lkt-induced cytolysis of ruminant ...
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... as clinically indicated; as surgical intervention may be required in certain severe cases (See ADVERSE REACTIONS). Immune Hypersensitivity Reactions Serious hypersensitivity reactions including apnea and bronchoconstriction have been reported in patients receiving polymyxin B sulphate by inhalation ...
... as clinically indicated; as surgical intervention may be required in certain severe cases (See ADVERSE REACTIONS). Immune Hypersensitivity Reactions Serious hypersensitivity reactions including apnea and bronchoconstriction have been reported in patients receiving polymyxin B sulphate by inhalation ...
Targeting the Bacterial Division Protein FtsZ
... (6) the cytoplasmic membrane.1,2 An important, unanswered question is whether additional classes of mechanisms and targets exist for developing new families of antibiotics. The bacterial cytoskeleton is one such family of targets for which clinical antibiotics have not yet emerged. The cytoskeleton ...
... (6) the cytoplasmic membrane.1,2 An important, unanswered question is whether additional classes of mechanisms and targets exist for developing new families of antibiotics. The bacterial cytoskeleton is one such family of targets for which clinical antibiotics have not yet emerged. The cytoskeleton ...
Antibody–Drug Conjugates (ADCs) Derived from
... suitable for conjugation. Later studies revealed that subtle differences in the ADC microenvironments significantly affect linker stability, which correlates with improved efficacy.14 The combined results indicate that ADC activity is highly dependent upon the conjugation sites and suggest that optimal c ...
... suitable for conjugation. Later studies revealed that subtle differences in the ADC microenvironments significantly affect linker stability, which correlates with improved efficacy.14 The combined results indicate that ADC activity is highly dependent upon the conjugation sites and suggest that optimal c ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.