CHITOSAN LOADED MICROSPHERES AS AN OCULAR DELIVERY SYSTEM FOR ACYCLOVIR S.SELVARAJ
... The aim of the present investigation was to evaluate the potential use of chitosan microspheres for ocular delivery of acyclovir. The topical application of acyclovir as eye ointment remains a concern for effective management of various ocular viral diseases owing to poor ocular drug bioavailability ...
... The aim of the present investigation was to evaluate the potential use of chitosan microspheres for ocular delivery of acyclovir. The topical application of acyclovir as eye ointment remains a concern for effective management of various ocular viral diseases owing to poor ocular drug bioavailability ...
Calcium Oscillations and its Functional Significance in
... signaling and actually tuned out by sustained [Ca2+]i signal31. In pancreatic -cells, KCl induced a sustained [Ca2+]i increase and transient [Ca2+]m increase, while glucose induced [Ca2+]i oscillations and an oscillatory [Ca2+]m increase, suggesting that repetitive transients of [Ca2+]m associated ...
... signaling and actually tuned out by sustained [Ca2+]i signal31. In pancreatic -cells, KCl induced a sustained [Ca2+]i increase and transient [Ca2+]m increase, while glucose induced [Ca2+]i oscillations and an oscillatory [Ca2+]m increase, suggesting that repetitive transients of [Ca2+]m associated ...
Active Transport of Fentanyl by the Blood-Brain Barrier1
... capacity and ko/kt is the KM or the supernatant drug concentration CS, which leads to 50% occupancy (inhibition) of transporters. Cell-associated [3H]fentanyl data, after being normalized for their protein content, were all fit simultaneously to eq. 1 using a constant weight and TableCurve2D (SPSS, ...
... capacity and ko/kt is the KM or the supernatant drug concentration CS, which leads to 50% occupancy (inhibition) of transporters. Cell-associated [3H]fentanyl data, after being normalized for their protein content, were all fit simultaneously to eq. 1 using a constant weight and TableCurve2D (SPSS, ...
Running Head: Superresolution of cortical
... at video rates (Marc et al., 1998; Shaw et al., 2013). However, the bulk of plant cells organized ...
... at video rates (Marc et al., 1998; Shaw et al., 2013). However, the bulk of plant cells organized ...
Core-specific adaptive regulatory T-cells in
... responses in chronic HCV (hepatitis C virus) infection; however, their antigen-specificity has remained elusive. In the present study, we analysed peripheral blood CD4+ Treg -cells in patients with chronic hepatitis C and subjects with self-limited HCV infection and characterized individual Treg -ce ...
... responses in chronic HCV (hepatitis C virus) infection; however, their antigen-specificity has remained elusive. In the present study, we analysed peripheral blood CD4+ Treg -cells in patients with chronic hepatitis C and subjects with self-limited HCV infection and characterized individual Treg -ce ...
Regulation of reactive oxygen species homeostasis
... (H2DCF-DA). An increase in fluorescence was observed in guard cells after t-Z treatment (Figure 3A), indicating that CK is able to induce ROS production. Notably, t-Z-mediated ROS production was compromised in the ahk3-3 and arr2 mutants and these mutants were also defective in flg22-mediated ROS pr ...
... (H2DCF-DA). An increase in fluorescence was observed in guard cells after t-Z treatment (Figure 3A), indicating that CK is able to induce ROS production. Notably, t-Z-mediated ROS production was compromised in the ahk3-3 and arr2 mutants and these mutants were also defective in flg22-mediated ROS pr ...
Platelet surface glutathione reductase-like activity
... collagen.7 When GSSG (5 M) was used alone as a control for the collagen-induced aggregation studies, surprisingly, it also enhanced platelet aggregation (Figure 1). As expected, GSSG alone did not contain any GSH by the 5,5⬘-dithiobis-(2-nitrobenzoid) acid (DTNB) assay (not shown). When the concent ...
... collagen.7 When GSSG (5 M) was used alone as a control for the collagen-induced aggregation studies, surprisingly, it also enhanced platelet aggregation (Figure 1). As expected, GSSG alone did not contain any GSH by the 5,5⬘-dithiobis-(2-nitrobenzoid) acid (DTNB) assay (not shown). When the concent ...
Lateral root initiation is a probabilistic event whose frequency is set
... et al., 2012). It will be interesting to see if light, gravity, circadian rhythms, or other factors affect the observed pulses of auxin response and LRI. The idea that LRI begins with pulses of auxin in the basal meristem is supported by the fact that the spatial pattern of LRP formation depends on ...
... et al., 2012). It will be interesting to see if light, gravity, circadian rhythms, or other factors affect the observed pulses of auxin response and LRI. The idea that LRI begins with pulses of auxin in the basal meristem is supported by the fact that the spatial pattern of LRP formation depends on ...
- Wiley Online Library
... This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. ...
... This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. ...
Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects
... After 1 hour of GD, the proportion of CMs with elongated mitochondria was increased, but that of CMs with foreshortened mitochondria was also increased slightly in Ad-shScr-transduced CMs (Figure 3C). A similar result was obtained in CMs transduced with adenovirus harboring LacZ (Ad-LacZ) (not shown ...
... After 1 hour of GD, the proportion of CMs with elongated mitochondria was increased, but that of CMs with foreshortened mitochondria was also increased slightly in Ad-shScr-transduced CMs (Figure 3C). A similar result was obtained in CMs transduced with adenovirus harboring LacZ (Ad-LacZ) (not shown ...
EC 3.4.22.32 - Bio
... various surgical procedures, including oral surgical procedures and episiotomy. It has also been used with significant positive results in the treatment of various athletic injuries. In one open case observation study, high-dose bromelain was administered to 59 patients with blunt injuries to the mu ...
... various surgical procedures, including oral surgical procedures and episiotomy. It has also been used with significant positive results in the treatment of various athletic injuries. In one open case observation study, high-dose bromelain was administered to 59 patients with blunt injuries to the mu ...
Biodegradable polyesters for medical and ecological applications
... transplanted organs, but both of the therapeutic methods involve some problems. As mentioned earlier, the biocompatibility of clinically used artificial organs is mostly not safisticatory enough to prevent severe foreign-body reactions and to fully perform the objective of the artificial organs aime ...
... transplanted organs, but both of the therapeutic methods involve some problems. As mentioned earlier, the biocompatibility of clinically used artificial organs is mostly not safisticatory enough to prevent severe foreign-body reactions and to fully perform the objective of the artificial organs aime ...
ภาพนิ่ง 1
... both inward K+ channels and S-type anion channels, which are required for stomatal opening (Schwartz et al. 1994; schroeder et al. 2001) ...
... both inward K+ channels and S-type anion channels, which are required for stomatal opening (Schwartz et al. 1994; schroeder et al. 2001) ...
A Prospective Experimental Study on the Protective Effect of
... Ototoxicity is a general term used for damage of the cochlear and/or vestibular organs; it results from exposure to several therapeutic agents and chemical substances [1]. Tinnitus is usually the first symptom of ototoxicity. Other symptoms include imbalance, hearing loss, and vertigo [2]. Aminoglyc ...
... Ototoxicity is a general term used for damage of the cochlear and/or vestibular organs; it results from exposure to several therapeutic agents and chemical substances [1]. Tinnitus is usually the first symptom of ototoxicity. Other symptoms include imbalance, hearing loss, and vertigo [2]. Aminoglyc ...
The Drosophila Sec7 domain guanine nucleotide exchange factor
... proteins in the ER, suggesting that excessive garz activity leads to increased retrograde trafficking. Thus, garz might regulate epithelial tube morphogenesis and secretion by controlling the rate of trafficking of COPI vesicles. Key words: Golgi, COPI, ARF, ARF-GEF, GBF1, Gartenzwerg, Drosophila me ...
... proteins in the ER, suggesting that excessive garz activity leads to increased retrograde trafficking. Thus, garz might regulate epithelial tube morphogenesis and secretion by controlling the rate of trafficking of COPI vesicles. Key words: Golgi, COPI, ARF, ARF-GEF, GBF1, Gartenzwerg, Drosophila me ...
Presynaptic Inhibition by GABA Is Mediated via Two Distinct GABA
... 1993).Suchbicuculline- and baclofen-resistantGABA receptors have in the past been called GABA, receptors(Johnston et al., 1975; Drew et al., 1984; Shimada et al., 1992). However, we found that the putative GABA, agonist cis-4-aminocrotonic acid (CACA) was much lesseffective than the Taurus isomer of ...
... 1993).Suchbicuculline- and baclofen-resistantGABA receptors have in the past been called GABA, receptors(Johnston et al., 1975; Drew et al., 1984; Shimada et al., 1992). However, we found that the putative GABA, agonist cis-4-aminocrotonic acid (CACA) was much lesseffective than the Taurus isomer of ...
Ectopic Expression of AINTEGUMENTA in Arabidopsis Plants
... phenotype. A defect in a late stage of pollen development appears to occur in 35S::ANT lines. Microspores with an exine wall are made and, in at least some cases, viable pollen grains are produced. Pollen viability was measured by staining with the dye fluorescein diacetate (FDA) [Regan and Moffatt, ...
... phenotype. A defect in a late stage of pollen development appears to occur in 35S::ANT lines. Microspores with an exine wall are made and, in at least some cases, viable pollen grains are produced. Pollen viability was measured by staining with the dye fluorescein diacetate (FDA) [Regan and Moffatt, ...
Pathology of The Parathyroid Glands
... familial (Familial hyperparathyroidism or multiple endocrine neoplasias (MEN) syndrome). It has been shown that hyperplasias and adenomas are monoclonal proliferations. Parathyroid hyperplasia associated with MEN I involves allelic deletions on chromosome 11. This suggests that the monoclonal prolif ...
... familial (Familial hyperparathyroidism or multiple endocrine neoplasias (MEN) syndrome). It has been shown that hyperplasias and adenomas are monoclonal proliferations. Parathyroid hyperplasia associated with MEN I involves allelic deletions on chromosome 11. This suggests that the monoclonal prolif ...
Review Biomedical applications of collagen
... 0.01–0.5 mm and made of biodegradable materials, such as prepared from telopeptide-free reconstituted collagen, demonstrated a slow release profile of incorporated drugs (Rubin et al., 1973). The drugs can be loaded into collagen membranes by hydrogen bonding, covalent bonding or simple entrapment. ...
... 0.01–0.5 mm and made of biodegradable materials, such as prepared from telopeptide-free reconstituted collagen, demonstrated a slow release profile of incorporated drugs (Rubin et al., 1973). The drugs can be loaded into collagen membranes by hydrogen bonding, covalent bonding or simple entrapment. ...
YEAST STRESS RESPONSES DURING ACCLIMATION FOR
... accumulation of toxic sub-products such as medium-chain fatty acids (MCFA) and organic acids. Others are found in the second fermentation: low temperature, low oxygen avaibaility, CO2 overpressure, presence of SO2 and total acidity (Juroszek et al. 1987). Some of these stress factors have a synergic ...
... accumulation of toxic sub-products such as medium-chain fatty acids (MCFA) and organic acids. Others are found in the second fermentation: low temperature, low oxygen avaibaility, CO2 overpressure, presence of SO2 and total acidity (Juroszek et al. 1987). Some of these stress factors have a synergic ...
ABA-based chemical signalling: the co-ordination of
... xylem stream (e.g. Correia & Pereira 1995). The reasons for these findings begin to become clear in the work of Trejo and colleagues (Trejo, Davies & Ruiz 1993; Trejo, Clephan & Davies 1995). Their data confirmed early work by Incoll & Jewer (1987a, b) that stomata in isolated epidermis were often s ...
... xylem stream (e.g. Correia & Pereira 1995). The reasons for these findings begin to become clear in the work of Trejo and colleagues (Trejo, Davies & Ruiz 1993; Trejo, Clephan & Davies 1995). Their data confirmed early work by Incoll & Jewer (1987a, b) that stomata in isolated epidermis were often s ...
(MMP)-2 and - UTHSC Digital Commons
... controlling its activation.26 In gingival crevicular fluid of patients with periodontitis TIMP-1 and TIMP-2 levels were found to be lower than in healthy control subjects.27 The expression of MMPs may be upregulated in some pathological conditions such as inflammation and tumor invasion. In the cont ...
... controlling its activation.26 In gingival crevicular fluid of patients with periodontitis TIMP-1 and TIMP-2 levels were found to be lower than in healthy control subjects.27 The expression of MMPs may be upregulated in some pathological conditions such as inflammation and tumor invasion. In the cont ...
Serum Factors from Pseudoxanthoma Elasticum
... transporter predominantly expressed in liver and kidneys. The functional relationship between ABCC6 and elastic fiber calcification is unknown. We speculated that ABCC6 deficiency in PXE patients induces a persistent imbalance in circulating metabolite(s), which may impair the synthetic abilities of ...
... transporter predominantly expressed in liver and kidneys. The functional relationship between ABCC6 and elastic fiber calcification is unknown. We speculated that ABCC6 deficiency in PXE patients induces a persistent imbalance in circulating metabolite(s), which may impair the synthetic abilities of ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.