Characterization of the Visceral Endoderm Components in Early
... the staff in GSBS and ISO office for all these years’ warm-hearted assistance. At last but mostly important, I would like to thank all my family and my relatives for their unconditional support and love, especially my parents who sacrificed themselves to provide me with good education and also my hu ...
... the staff in GSBS and ISO office for all these years’ warm-hearted assistance. At last but mostly important, I would like to thank all my family and my relatives for their unconditional support and love, especially my parents who sacrificed themselves to provide me with good education and also my hu ...
The N-Terminal Domain of ERK1 Accounts for the Functional
... these two proteins. While the genetic ablation of ERK2 in mice results in embryonic lethality, loss of ERK1 only causes deficits in tymocyte maturation and subtle alterations in synaptic plasticity and behaviour [12,13]. Significant differences between the two kinases also appear in the control of c ...
... these two proteins. While the genetic ablation of ERK2 in mice results in embryonic lethality, loss of ERK1 only causes deficits in tymocyte maturation and subtle alterations in synaptic plasticity and behaviour [12,13]. Significant differences between the two kinases also appear in the control of c ...
BACTERIAL FUNGAL INTERACTIONS IN THE CYSTIC FIBROSIS
... in a significant decrease in elastase produced by certain P. aeruginosa strains. ...
... in a significant decrease in elastase produced by certain P. aeruginosa strains. ...
Sensitive Interaction between Raptor a
... 1998; Isotani et al., 1999). The GL siRNA did not significantly affect the expression of S6K1 or ATM, or the phosphorylation state or amount of PKB1/Akt1, a downstream effector of PI 3-Kinase. Unlike a decrease in raptor expression (Kim et al., 2002), a reduction in GL expression did not also redu ...
... 1998; Isotani et al., 1999). The GL siRNA did not significantly affect the expression of S6K1 or ATM, or the phosphorylation state or amount of PKB1/Akt1, a downstream effector of PI 3-Kinase. Unlike a decrease in raptor expression (Kim et al., 2002), a reduction in GL expression did not also redu ...
Polarization of the endomembrane system is an early event in fucoid
... endomembranes were asymmetrically distributed toward the rhizoid pole and organelles deep into the cytoplasm were clearly labeled (Fig. 5a). In contrast, FM4-64 incorporated into the plasma membrane in Lat B-treated zygotes (Fig. 5b), but was not internalized to membranous organelles in any of the z ...
... endomembranes were asymmetrically distributed toward the rhizoid pole and organelles deep into the cytoplasm were clearly labeled (Fig. 5a). In contrast, FM4-64 incorporated into the plasma membrane in Lat B-treated zygotes (Fig. 5b), but was not internalized to membranous organelles in any of the z ...
Preparation and Characterization of Cellulose Nanocrystals from
... cob were studied. These are the acetic acid - nitric acid mixture and the delignification with acidified sodium chlorite. The treatment of sugarcane bagasse and corn cob with the 80% acetic acid- 70% nitric acid mixture at 120 ºC yielded 38.6% and 28.6% of cellulose, respectively. Another treatment ...
... cob were studied. These are the acetic acid - nitric acid mixture and the delignification with acidified sodium chlorite. The treatment of sugarcane bagasse and corn cob with the 80% acetic acid- 70% nitric acid mixture at 120 ºC yielded 38.6% and 28.6% of cellulose, respectively. Another treatment ...
Paralytic Shellfish Poisoning Toxins: Biochemistry and Origin Masaaki Kodama
... and fisheries industry. The causative organisms of PSP toxins are known to be species of dinoflagellates including those belonging to the genus Alexandrium, Gymnodinium catenatum and Pyrodinium bahamense var. compressum. Bivalves accumulate PSP toxins during a bloom of these dinoflagellates. Thus, t ...
... and fisheries industry. The causative organisms of PSP toxins are known to be species of dinoflagellates including those belonging to the genus Alexandrium, Gymnodinium catenatum and Pyrodinium bahamense var. compressum. Bivalves accumulate PSP toxins during a bloom of these dinoflagellates. Thus, t ...
Par3/Baz levels control epithelial folding at actomyosin
... reporters for Myosin II, MHC-GFP and MRLC-GFP, are enriched at PSBs at stage 10 (Monier et al., 2010). By quantifying the enrichment along the PSBs relative to control columns of DV-oriented junctions, we now find that Myosin II is not only enriched but also activated: the monophosphorylated form of ...
... reporters for Myosin II, MHC-GFP and MRLC-GFP, are enriched at PSBs at stage 10 (Monier et al., 2010). By quantifying the enrichment along the PSBs relative to control columns of DV-oriented junctions, we now find that Myosin II is not only enriched but also activated: the monophosphorylated form of ...
Full Text - Labs / Projects - Fred Hutchinson Cancer Research Center
... concentrated apically, in blastoderm embryos. (A,B) Confocal micrograph showing Rho1 localization at interphase (A) and metaphase (B) in an early syncytial blastoderm stage. Note that the accumulation of Rho protein (arrows) relative to nuclei (arrowheads) changes with cell cycle phase. (C-D′) Confo ...
... concentrated apically, in blastoderm embryos. (A,B) Confocal micrograph showing Rho1 localization at interphase (A) and metaphase (B) in an early syncytial blastoderm stage. Note that the accumulation of Rho protein (arrows) relative to nuclei (arrowheads) changes with cell cycle phase. (C-D′) Confo ...
The Potential of Stimuli-Responsive Nanogels in Drug and Active
... Abstract: Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and protection of active agents from degradation, which make them ideal candidates as drug delivery systems (DDS). Stimuli-responsive NGs ar ...
... Abstract: Nanogels (NGs) are currently under extensive investigation due to their unique properties, such as small particle size, high encapsulation efficiency and protection of active agents from degradation, which make them ideal candidates as drug delivery systems (DDS). Stimuli-responsive NGs ar ...
Deep Insight Section Mechanisms and regulation of autophagy in mammalian cells
... organelles. There are two major systems in eukaryotic cells that degrade cellular components: the ubiquitin proteasome system (UPS) and the lysosome. The UPS only degrades proteins, mainly short-lived proteins that have to be tagged by ubiquitin to be recognized by the proteasome (Ciechanover et al. ...
... organelles. There are two major systems in eukaryotic cells that degrade cellular components: the ubiquitin proteasome system (UPS) and the lysosome. The UPS only degrades proteins, mainly short-lived proteins that have to be tagged by ubiquitin to be recognized by the proteasome (Ciechanover et al. ...
Down-Regulates Expression of Cell Proliferation
... One of these traditional medicines, curcumin, is a component of the culinary spice turmeric, which is also often used in curry powder. Its active ingredient was first isolated in 1842 by Vogel. In 1910, Milobedzka determined that the structure was diferuloylmethane, and this compound was first synth ...
... One of these traditional medicines, curcumin, is a component of the culinary spice turmeric, which is also often used in curry powder. Its active ingredient was first isolated in 1842 by Vogel. In 1910, Milobedzka determined that the structure was diferuloylmethane, and this compound was first synth ...
The Plant Actin Cytoskeleton Responds to Signals from Microbe
... actin filaments in the cortical array of epidermal cells inoculated with DC3000 (Figure 1B) or hrpH (Figure 1C), compared to mocktreated material (Figure 1A). At 24 hpi, we noticed little difference between the mock control (Figure 1D) and hrpH inoculation (Figure 1F); however, obvious actin filamen ...
... actin filaments in the cortical array of epidermal cells inoculated with DC3000 (Figure 1B) or hrpH (Figure 1C), compared to mocktreated material (Figure 1A). At 24 hpi, we noticed little difference between the mock control (Figure 1D) and hrpH inoculation (Figure 1F); however, obvious actin filamen ...
Downstream EGFR Protein Phosphorylation and Gefitinib - Bio-Rad
... The purpose of this study was to detect the effects of gefitinib (marketed as Iressa by AstraZeneca Pharmaceuticals) on the phosphorylation of downstream targets of EGFR (Figure 1) and to show the application of Bio-Plex® phosphoprotein assays to drug discovery based on signal transduction pathways. ...
... The purpose of this study was to detect the effects of gefitinib (marketed as Iressa by AstraZeneca Pharmaceuticals) on the phosphorylation of downstream targets of EGFR (Figure 1) and to show the application of Bio-Plex® phosphoprotein assays to drug discovery based on signal transduction pathways. ...
NIH Public Access - Khademhosseini Lab
... nanocomposite network was observed for more than a week, which is otherwise difficult to achieve when using conventional hydrogels made from linear polymers. Overall, a range of dendrimers/hyperbranched-based nanocomposite hydrogels with tailored physical and chemical properties has been evaluated f ...
... nanocomposite network was observed for more than a week, which is otherwise difficult to achieve when using conventional hydrogels made from linear polymers. Overall, a range of dendrimers/hyperbranched-based nanocomposite hydrogels with tailored physical and chemical properties has been evaluated f ...
Characterization of Vincristine Transport by the Mr 190,000
... The .I/, 190,000 multidrug resistance protein (MRP) confers resistance to a broad spectrum of natural product drugs. However, it has not been possible to demonstrate that MRP can actively transport unmodified forms of these compounds, although the protein has been shown to transport structurally div ...
... The .I/, 190,000 multidrug resistance protein (MRP) confers resistance to a broad spectrum of natural product drugs. However, it has not been possible to demonstrate that MRP can actively transport unmodified forms of these compounds, although the protein has been shown to transport structurally div ...
2 AgCHNES JUN Engineered Microneedles for Transcutaneous Vaccine Delivery
... generate vaccine-loaded conformal coatings on the surface of these microneedle arrays, which are The construction of coatings then delivered into the skin through topical patch application. containing antigen-expressing plasmid DNA (pDNA), together with immune-stimulatory RNA, and degradable cationi ...
... generate vaccine-loaded conformal coatings on the surface of these microneedle arrays, which are The construction of coatings then delivered into the skin through topical patch application. containing antigen-expressing plasmid DNA (pDNA), together with immune-stimulatory RNA, and degradable cationi ...
Melatonin as a potential anticarcinogen for non-small
... antigen (PCNA) is a molecular marker for proliferation because of its role in cell division; the inhibition of PCNA is considered to be a viable anticancer strategy [91]. Our recent study demonstrated that melatonin supplementation downregulated PCNA expression and reduced the viability in both lung ...
... antigen (PCNA) is a molecular marker for proliferation because of its role in cell division; the inhibition of PCNA is considered to be a viable anticancer strategy [91]. Our recent study demonstrated that melatonin supplementation downregulated PCNA expression and reduced the viability in both lung ...
The SOX9 upstream region prone to chromosomal aberrations
... dysplasia (1,2,23,24). Aberrations occurring ∼1.1 Mb upstream of SOX9 cause Robin sequence, manifested by micrognathia, glossoptosis and cleft palate and aberrations occurring downstream of SOX9 have been mostly associated with Robin sequence and acampomelic dysplasia (22,25). Based on these disease ...
... dysplasia (1,2,23,24). Aberrations occurring ∼1.1 Mb upstream of SOX9 cause Robin sequence, manifested by micrognathia, glossoptosis and cleft palate and aberrations occurring downstream of SOX9 have been mostly associated with Robin sequence and acampomelic dysplasia (22,25). Based on these disease ...
Biogenesis and multifaceted roles of outer membrane
... & Kuehn, 2000; Kato et al., 2002; Nevot et al., 2006). Apparently, OM phospholipids are present in the membranes of OMVs (Tashiro et al., 2011; Chowdhury & Jagannadham, 2013; Kulkarni et al., 2014), and there is evidence that OMVs contain some lipids that are not detected in the OM (Kato et al., 200 ...
... & Kuehn, 2000; Kato et al., 2002; Nevot et al., 2006). Apparently, OM phospholipids are present in the membranes of OMVs (Tashiro et al., 2011; Chowdhury & Jagannadham, 2013; Kulkarni et al., 2014), and there is evidence that OMVs contain some lipids that are not detected in the OM (Kato et al., 200 ...
Sequestration of host metabolism by an intracellular pathogen | eLife
... Part of luminal glycogen is translocated in bulk from the host cytoplasm Our conclusion raised an obvious question: how could a large polymer appear in the inclusion lumen? Two mechanisms are conceivable: bulk translocation of host glycogen, or transport of monomeric substrates (such as nucleotide-s ...
... Part of luminal glycogen is translocated in bulk from the host cytoplasm Our conclusion raised an obvious question: how could a large polymer appear in the inclusion lumen? Two mechanisms are conceivable: bulk translocation of host glycogen, or transport of monomeric substrates (such as nucleotide-s ...
ABSTRACT Title of Document:
... phase of B and T lymphocyte development coincides with the change in macronutrient supply associated with the embryonic to posthatch transition. Lymphocyte development in primary immune tissues is integrated with their bioenergetic status. Developing lymphocytes proliferate extensively in primary i ...
... phase of B and T lymphocyte development coincides with the change in macronutrient supply associated with the embryonic to posthatch transition. Lymphocyte development in primary immune tissues is integrated with their bioenergetic status. Developing lymphocytes proliferate extensively in primary i ...
Coactivation of Syk Kinase and MyD88 Adaptor Protein Pathways by
... LPS by shedding L-selectin and upregulation of CD11b (Andonegui et al., 2003). Several studies have identified murine neutrophils as a major source of cytokines, including TNF-a (Bennouna and Denkers, 2005) and IL-12 (Romani et al., 1997; Bliss et al., 2000), after stimulation by LPS or Toxoplasma g ...
... LPS by shedding L-selectin and upregulation of CD11b (Andonegui et al., 2003). Several studies have identified murine neutrophils as a major source of cytokines, including TNF-a (Bennouna and Denkers, 2005) and IL-12 (Romani et al., 1997; Bliss et al., 2000), after stimulation by LPS or Toxoplasma g ...
The Aspergillus fumigatus cspA Gene Encoding a Repeat
... pathogen and the major causative agent of invasive aspergillosis, a life-threatening disease primarily affecting immunocompromised patients (12, 16, 38). Molecular analyses have revealed numerous virulence attributes that enable A. fumigatus to infect the human host, including the production of toxi ...
... pathogen and the major causative agent of invasive aspergillosis, a life-threatening disease primarily affecting immunocompromised patients (12, 16, 38). Molecular analyses have revealed numerous virulence attributes that enable A. fumigatus to infect the human host, including the production of toxi ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.