The Effects of Antibiotics and Cancer
... therapy in acute leukemia and the lymphomas (4, 9, 12), MTX is now being used in combination with many other cancer chemotherapeutic agents for the treatment of other human malignant neoplasms. Patients being treated with MTX often receive many other pharmacologically active compounds concomitantly. ...
... therapy in acute leukemia and the lymphomas (4, 9, 12), MTX is now being used in combination with many other cancer chemotherapeutic agents for the treatment of other human malignant neoplasms. Patients being treated with MTX often receive many other pharmacologically active compounds concomitantly. ...
Actin Dynamics in Muscle Cells
... costamere set of proteins close to cell membrane providing membrane linkage between myofibril and sarcolemma contractility ability of cell to shorten or shrink in respond to stimuli. Contractility is generated by the myosin motor proteins which use ATP hydrolysis as an energy source. FRAP an imaging ...
... costamere set of proteins close to cell membrane providing membrane linkage between myofibril and sarcolemma contractility ability of cell to shorten or shrink in respond to stimuli. Contractility is generated by the myosin motor proteins which use ATP hydrolysis as an energy source. FRAP an imaging ...
Interplay Between Phospholipids and
... Phosphate is an essential nutrient. In most soils it is limiting, which has resulted in that phosphate is supplied as fertilizer to increase crop yield. Through evolution, plants have adapted several mechanisms to increase phosphate uptake from the soil and to household with acquired phosphate. A re ...
... Phosphate is an essential nutrient. In most soils it is limiting, which has resulted in that phosphate is supplied as fertilizer to increase crop yield. Through evolution, plants have adapted several mechanisms to increase phosphate uptake from the soil and to household with acquired phosphate. A re ...
Damage response of XRCC1 at sites of DNA single strand breaks is
... formed an increased number of both endogenous and MMSinduced foci (Fig. 1A), indicating that X1 pm is retained at sites of both endogenous and exogenous damage for a longer time. The cells with foci were counted and percentages are shown in Fig. 1B before and 10 minutes or 1 hour after MMS treatment ...
... formed an increased number of both endogenous and MMSinduced foci (Fig. 1A), indicating that X1 pm is retained at sites of both endogenous and exogenous damage for a longer time. The cells with foci were counted and percentages are shown in Fig. 1B before and 10 minutes or 1 hour after MMS treatment ...
Further analysis on lidocaine-induced increase in intracellular Zn2+
... suggesting the decrease in cellular content of nonprotein thiols. Since some peptides consisting of SH-group have been proposed to store Zn2+, the decrease in nonprotein thiol content by lidocaine reduced the cellular ability to store Zn2+, leading to an increase in intracellular Zn2+ concentration. ...
... suggesting the decrease in cellular content of nonprotein thiols. Since some peptides consisting of SH-group have been proposed to store Zn2+, the decrease in nonprotein thiol content by lidocaine reduced the cellular ability to store Zn2+, leading to an increase in intracellular Zn2+ concentration. ...
Stomatal Size, Speed, and Responsiveness
... stomata of leaves every year (Hetherington and Woodward, 2003). Changes in stomatal behavior in response to changing climatic conditions are thought to impact on water levels and fluxes. For example, it is estimated that partial stomatal closure driven by increasing CO2 concentration over the past tw ...
... stomata of leaves every year (Hetherington and Woodward, 2003). Changes in stomatal behavior in response to changing climatic conditions are thought to impact on water levels and fluxes. For example, it is estimated that partial stomatal closure driven by increasing CO2 concentration over the past tw ...
The versatility of mitochondrial calcium signals: From stimulation of
... authors' own work on the topic. We apologize in advance for the bias and the omissions. Please refer to more extended reviews for the aspects that are overlooked. 2. Mitochondrial Ca2+ homeostasis Mitochondria are delimited by two membranes. The outer mitochondrial membrane (OMM) is permeable to ion ...
... authors' own work on the topic. We apologize in advance for the bias and the omissions. Please refer to more extended reviews for the aspects that are overlooked. 2. Mitochondrial Ca2+ homeostasis Mitochondria are delimited by two membranes. The outer mitochondrial membrane (OMM) is permeable to ion ...
Characterization and Evaluation of a Novel Tissue
... facilitates shearing of the external layers. Our working hypothesis is that partially crosslinked collagen scaffolds that closely mimic the layered histo-architecture of the native valve would fulfill these requirements. To test this hypothesis we have developed heart valve-shaped tri-layered constr ...
... facilitates shearing of the external layers. Our working hypothesis is that partially crosslinked collagen scaffolds that closely mimic the layered histo-architecture of the native valve would fulfill these requirements. To test this hypothesis we have developed heart valve-shaped tri-layered constr ...
Potential applications of chitosan in veterinary medicine
... weight, the elongation at break and the tensile strength [7]. Viscosity also influences biological properties such as wound-healing properties and osteogenesis enhancement as well as biodegradation by lysozyme [8]. Chitosan, which is polycationic in acidic environments, possesses an ability to form ...
... weight, the elongation at break and the tensile strength [7]. Viscosity also influences biological properties such as wound-healing properties and osteogenesis enhancement as well as biodegradation by lysozyme [8]. Chitosan, which is polycationic in acidic environments, possesses an ability to form ...
Astragalus membranaceus Monograph
... Astragaloside IV was isolated from Astragalus membranaceus and injected intravenously in 19 patients with congestive heart failure daily for two weeks. After two weeks, symptoms of chest pain and dyspnea were alleviated in 15 of 19 patients. Additionally, radionuclide ventriculography showed with st ...
... Astragaloside IV was isolated from Astragalus membranaceus and injected intravenously in 19 patients with congestive heart failure daily for two weeks. After two weeks, symptoms of chest pain and dyspnea were alleviated in 15 of 19 patients. Additionally, radionuclide ventriculography showed with st ...
RA/FGF control Meis in PD limb development
... González-Crespo et al., 1998; González-Crespo and Morata, ...
... González-Crespo et al., 1998; González-Crespo and Morata, ...
ayout 1
... should be alerted to the potential for additive central nervous system depression if Dronabinol Capsules is used concomitantly with alcohol or other CNS depressants such as benzodiazepines and barbiturates. Patients receiving treatment with Dronabinol Capsules should be specifically warned not to dr ...
... should be alerted to the potential for additive central nervous system depression if Dronabinol Capsules is used concomitantly with alcohol or other CNS depressants such as benzodiazepines and barbiturates. Patients receiving treatment with Dronabinol Capsules should be specifically warned not to dr ...
Cytokinins regulate vascular morphogenesis in the Arabidopsis
... land. These ancestors of the first terrestrial plants were able to cope with occasional drying, when growing on streams or mudflats, but they were still tightly depended on living on water. To successfully accomplish the transition from aquatic to terrestrial life, several structural and functional ...
... land. These ancestors of the first terrestrial plants were able to cope with occasional drying, when growing on streams or mudflats, but they were still tightly depended on living on water. To successfully accomplish the transition from aquatic to terrestrial life, several structural and functional ...
Mechanisms, Measurement, and Significance of Lung Macrophage
... They may release chemotactic factors and a variety of mediatos They ingest and degrade antigens and are microbicidal. Interstitial macrophages are in direct contact with the extracellular matrix as well as other cells in pulmonary connective tissue such as fibroblasts. Thus, release of mediators or ...
... They may release chemotactic factors and a variety of mediatos They ingest and degrade antigens and are microbicidal. Interstitial macrophages are in direct contact with the extracellular matrix as well as other cells in pulmonary connective tissue such as fibroblasts. Thus, release of mediators or ...
A three-stage model of Golgi structure and function
... separation enables the cell to optimize the pH, ion composition, and substrate concentrations for each set of enzymes. Moreover, enzyme separation may sometimes be essential to prevent two reactions from competing. For example, mammalian lysosomal hydrolases are modified with a mannose 6-phosphate s ...
... separation enables the cell to optimize the pH, ion composition, and substrate concentrations for each set of enzymes. Moreover, enzyme separation may sometimes be essential to prevent two reactions from competing. For example, mammalian lysosomal hydrolases are modified with a mannose 6-phosphate s ...
Dissecting stimulus-specific Ca2+ signals in amyloplasts and
... signal transduction. This allowed us to monitor in parallel Ca2+ dynamics in the bulk cytosol, the cytosolic microdomain just outside plastids (by means of the aequorin chimera targeted to the cytosolic surface of the plastid outer envelope), and the organelle stroma. [Ca2+] in all these subcellular ...
... signal transduction. This allowed us to monitor in parallel Ca2+ dynamics in the bulk cytosol, the cytosolic microdomain just outside plastids (by means of the aequorin chimera targeted to the cytosolic surface of the plastid outer envelope), and the organelle stroma. [Ca2+] in all these subcellular ...
Melatonin - Sweetwater OB GYN
... responsible for bringing on sleep. Nocturnal melatonin production is highest in children and begins to decline from adolescence on until it is virtually absent in the elderly. Melatonin supports normal immune function by helping maintain the activity of circulating natural killer cells. It also has ...
... responsible for bringing on sleep. Nocturnal melatonin production is highest in children and begins to decline from adolescence on until it is virtually absent in the elderly. Melatonin supports normal immune function by helping maintain the activity of circulating natural killer cells. It also has ...
Chato, a KRAB zinc-finger protein, regulates
... rearrangements that lead to convergent extension during early somite stages, and that these cell rearrangements fail in chato embryos. Although non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural plate, the results indicate that chato regulates body ax ...
... rearrangements that lead to convergent extension during early somite stages, and that these cell rearrangements fail in chato embryos. Although non-canonical Wnt signaling is important for convergent extension in the mouse notochord and neural plate, the results indicate that chato regulates body ax ...
Maltose uptake and its regulation in Bacillus subtilis
... 47°C (Table 1). The most probable conclusion from these experiments is that maltose transport, although non-PTS, is regulated by the PTS in B. ...
... 47°C (Table 1). The most probable conclusion from these experiments is that maltose transport, although non-PTS, is regulated by the PTS in B. ...
The toxicity, pharmacokinetics, anti
... MTX against a colon cancer cell line (COLO 320 DM). This high cytotoxic effect warranted further investigation in an in vivo colon cancer tumour model. An induced murine tumour model of COLO 320 DM was successfully developed in nude mice, and the anti-tumour efficacy of D85 tested in this model. The ...
... MTX against a colon cancer cell line (COLO 320 DM). This high cytotoxic effect warranted further investigation in an in vivo colon cancer tumour model. An induced murine tumour model of COLO 320 DM was successfully developed in nude mice, and the anti-tumour efficacy of D85 tested in this model. The ...
current models for the structure of biological membranes rev iew
... in the intracellular membranes . Fourth, most of the material outside this layer can be removed without seriously impairing the viability of a cell, whereas an intact cell membrane is an absolutely essential component of living cells . Since no general compositional or structural principles have so ...
... in the intracellular membranes . Fourth, most of the material outside this layer can be removed without seriously impairing the viability of a cell, whereas an intact cell membrane is an absolutely essential component of living cells . Since no general compositional or structural principles have so ...
ABSTRACT Title of Dissertation: GENETIC REGULATION OF AUTOPHAGIC CELL... Sudeshna Dutta, Doctor of Philosophy, 2008
... grateful for what he has done for me. My cordial thank to my committee member and MOCB program director Dr. Leslie Pick for her guidance and support. I am also grateful to my other committee members: Dr. Louisa Wu for her suggestions and encouragements, Dr. Stephen Mount for his guidance and advice, ...
... grateful for what he has done for me. My cordial thank to my committee member and MOCB program director Dr. Leslie Pick for her guidance and support. I am also grateful to my other committee members: Dr. Louisa Wu for her suggestions and encouragements, Dr. Stephen Mount for his guidance and advice, ...
Profilin association with monomeric actin in
... methods we find that a majority of Acanthamoeba profilin is bound to actin monomers and is spread relatively uniformly throughout the cytoplasm. In gel-filtration experiments no profilin was associated with particles larger than monomeric actin, so the other partners of profilin must be present in l ...
... methods we find that a majority of Acanthamoeba profilin is bound to actin monomers and is spread relatively uniformly throughout the cytoplasm. In gel-filtration experiments no profilin was associated with particles larger than monomeric actin, so the other partners of profilin must be present in l ...
Cell encapsulation
Cell microencapsulation technology involves immobilization of the cells within a polymeric semi-permeable membrane that permits the bidirectional diffusion of molecules such as the influx of oxygen, nutrients, growth factors etc. essential for cell metabolism and the outward diffusion of waste products and therapeutic proteins. At the same time, the semi-permeable nature of the membrane prevents immune cells and antibodies from destroying the encapsulated cells regarding them as foreign invaders.The main motive of cell encapsulation technology is to overcome the existing problem of graft rejection in tissue engineering applications and thus reduce the need for long-term use of immunosuppressive drugs after an organ transplant to control side effects.