The network of calcium regulation in muscle
... The surface membrane Ca2+ pumps are of primary importance in the regulation of total cell Ca2+ content. Their cellular concentration and activity are adjusted to compensate for the influx of extracellular Ca2+, but very little is known about the mechanism of this regulation. In healthy red blood cel ...
... The surface membrane Ca2+ pumps are of primary importance in the regulation of total cell Ca2+ content. Their cellular concentration and activity are adjusted to compensate for the influx of extracellular Ca2+, but very little is known about the mechanism of this regulation. In healthy red blood cel ...
Redefining the role of ectoderm in somitogenesis
... Isabel Palmeirim3 and Sólveig Thorsteinsdóttir1,2,‡ The absence of ectoderm impairs somite formation in cultured presomitic mesoderm (PSM) explants, suggesting that an ectodermderived signal is essential for somitogenesis. Here we show in chick that the standard enzymatic treatments used for explant ...
... Isabel Palmeirim3 and Sólveig Thorsteinsdóttir1,2,‡ The absence of ectoderm impairs somite formation in cultured presomitic mesoderm (PSM) explants, suggesting that an ectodermderived signal is essential for somitogenesis. Here we show in chick that the standard enzymatic treatments used for explant ...
SACpaper-TMG12-27 FS..
... be functioning within local microdomains. In support of this notion, chelating local Ca2+ signals with BAPTA prevents the acceleration that is normally produced by GsMTx4. Additionally, stimulation of neurite outgrowth by blocking stretch-activated Ca2+ channels appears to require continued Ca2+ rel ...
... be functioning within local microdomains. In support of this notion, chelating local Ca2+ signals with BAPTA prevents the acceleration that is normally produced by GsMTx4. Additionally, stimulation of neurite outgrowth by blocking stretch-activated Ca2+ channels appears to require continued Ca2+ rel ...
store-operated calcium channels
... depletion of an intracellular Ca2⫹ pool and importantly that IP3 and TG had nonadditive effects, suggesting that they activate the same Ca2⫹ influx pathway. It soon became evident that the Ca2⫹ entry induced by TCR agonists and SERCA inhibitors shared key properties, suggesting that the currents in ...
... depletion of an intracellular Ca2⫹ pool and importantly that IP3 and TG had nonadditive effects, suggesting that they activate the same Ca2⫹ influx pathway. It soon became evident that the Ca2⫹ entry induced by TCR agonists and SERCA inhibitors shared key properties, suggesting that the currents in ...
C/EBPα triggers proteasome‐dependent degradation of cdk4 during
... examine whether the lack of C/EBPa in these tissues affects cdk4 protein levels, cdk4 levels were examined in the brown fat, lung and kidney (C/EBPa is not expressed) of C/EBPa-knockout and wild-type littermates. Western blot analyses of nuclear extracts from three animals of each genotype are shown ...
... examine whether the lack of C/EBPa in these tissues affects cdk4 protein levels, cdk4 levels were examined in the brown fat, lung and kidney (C/EBPa is not expressed) of C/EBPa-knockout and wild-type littermates. Western blot analyses of nuclear extracts from three animals of each genotype are shown ...
Pulmonary Surfactant Protein A Activates a
... Alison A. Beharka,* Joy E. Crowther,*† Francis X. McCormack,‡ Gerene M. Denning,* Jason Lees,* Eric Tibesar,* and Larry S. Schlesinger2† Surfactant protein A (SP-A), a major component of lung surfactant, binds to macrophages and has been shown to alter several macrophage biological functions, includ ...
... Alison A. Beharka,* Joy E. Crowther,*† Francis X. McCormack,‡ Gerene M. Denning,* Jason Lees,* Eric Tibesar,* and Larry S. Schlesinger2† Surfactant protein A (SP-A), a major component of lung surfactant, binds to macrophages and has been shown to alter several macrophage biological functions, includ ...
Functional analysis of parvin and different modes of IPP
... muscle attachment sites (MASs) in Drosophila. Here we showed that parvin null mutants in Drosophila exhibit defects in muscle adhesion, similar to ILK and PINCH mutants. Furthermore, the identical muscle phenotype of the triple mutant, which for the first time in any organism removed the entire IPP- ...
... muscle attachment sites (MASs) in Drosophila. Here we showed that parvin null mutants in Drosophila exhibit defects in muscle adhesion, similar to ILK and PINCH mutants. Furthermore, the identical muscle phenotype of the triple mutant, which for the first time in any organism removed the entire IPP- ...
Calcium at Fertilization and in Early Development
... Whitaker, Michael. Calcium at Fertilization and in Early Development. Physiol Rev 86: 25– 88, 2006; doi:10.1152/physrev.00023.2005.—Fertilization calcium waves are introduced, and the evidence from which we can infer general mechanisms of these waves is presented. The two main classes of hypotheses ...
... Whitaker, Michael. Calcium at Fertilization and in Early Development. Physiol Rev 86: 25– 88, 2006; doi:10.1152/physrev.00023.2005.—Fertilization calcium waves are introduced, and the evidence from which we can infer general mechanisms of these waves is presented. The two main classes of hypotheses ...
Donohoe, B.S., B. - University of Colorado-MCDB
... for investigation and validation of the cisternal progression/maturation model of Golgi-mediated membrane trafficking (50–52). Most notably, during flagellar regeneration each S. dubia Golgi stack produces a new cisterna every 15 s (18,53), which greatly enhances the possibility of observing assembl ...
... for investigation and validation of the cisternal progression/maturation model of Golgi-mediated membrane trafficking (50–52). Most notably, during flagellar regeneration each S. dubia Golgi stack produces a new cisterna every 15 s (18,53), which greatly enhances the possibility of observing assembl ...
life cycle, cell wall and cell signal transduction
... 2002). The cell surface molecules that mediate this response have not been fully characterized. Major surface glycoprotein (MSG) expressed in the Pneumocystis cell wall has been shown to interact with fibronectin (Pottratz et al. 1991), but this is probably not the primary mechanism behind the cell ...
... 2002). The cell surface molecules that mediate this response have not been fully characterized. Major surface glycoprotein (MSG) expressed in the Pneumocystis cell wall has been shown to interact with fibronectin (Pottratz et al. 1991), but this is probably not the primary mechanism behind the cell ...
Influence of the 4G/5G PAI-1 genotype on angiotensin II
... whether those effects differ according to the 4G/5G endothelial cell genotype. Recent reports have also demonstrated that the relationship between Ang II and PAI-1 would be mediated by the angiotensin II type 1 (AT1) receptor [17,18]; furthermore, AT1 receptor blockers have been shown to attenuate a ...
... whether those effects differ according to the 4G/5G endothelial cell genotype. Recent reports have also demonstrated that the relationship between Ang II and PAI-1 would be mediated by the angiotensin II type 1 (AT1) receptor [17,18]; furthermore, AT1 receptor blockers have been shown to attenuate a ...
POPCORN Functions in the Auxin Pathway to Regulate
... Development of pcn embryos was similar to the wild type until the two-cell embryo stage (Figures 3A and 3C versus Figures 3K and 3M). Subsequently, with delayed apical cell divisions, more suspensor cells were observed when compared with the wild type (Figures 3L to 3V). Occasionally, abnormal verti ...
... Development of pcn embryos was similar to the wild type until the two-cell embryo stage (Figures 3A and 3C versus Figures 3K and 3M). Subsequently, with delayed apical cell divisions, more suspensor cells were observed when compared with the wild type (Figures 3L to 3V). Occasionally, abnormal verti ...
understanding the role of sumoylation in regulating lkb1 function
... subcellular localization. At the molecular level, SUMOylation can (1) inhibit the interaction between the target and its interacting partner, (2) enhance this interaction through creation of a binding surface where the target would recognize the partner via a SUMO-interacting motif (SIM), or (3) cha ...
... subcellular localization. At the molecular level, SUMOylation can (1) inhibit the interaction between the target and its interacting partner, (2) enhance this interaction through creation of a binding surface where the target would recognize the partner via a SUMO-interacting motif (SIM), or (3) cha ...
PIN-Dependent Auxin Transport: Action, Regulation
... The canonical, plasma membrane-localized PINs, which consist of two transmembrane regions separated by a long hydrophilic loop, are represented in Arabidopsis by five members: PIN1-4 and PIN7. By contrast, PIN5, PIN6, and PIN8 are characterized by a reduction in the middle hydrophilic loop, partially ...
... The canonical, plasma membrane-localized PINs, which consist of two transmembrane regions separated by a long hydrophilic loop, are represented in Arabidopsis by five members: PIN1-4 and PIN7. By contrast, PIN5, PIN6, and PIN8 are characterized by a reduction in the middle hydrophilic loop, partially ...
Utilization and Transport of Mannitol in Olea
... mechanism would be associated with a net influx of positive charges into the cells, the effect of the dissipation of transmembrane electric potential on mannitol transport was studied. Fig. 4B shows the effect of the lipophilic cation tetraphenylphosphonium (TPPþ) on the initial uptake rates of 0.2– ...
... mechanism would be associated with a net influx of positive charges into the cells, the effect of the dissipation of transmembrane electric potential on mannitol transport was studied. Fig. 4B shows the effect of the lipophilic cation tetraphenylphosphonium (TPPþ) on the initial uptake rates of 0.2– ...
Alternative splicing of human cyclin E - Journal of Cell Science
... human cyclin E: evidence for alternative splicing In the course of analysing the expression of the cyclin E gene in different cell lines we observed a second minor RNA species that was slightly smaller than the major RNA representing the previously described cyclin E (Koff et al., 1991). This shorte ...
... human cyclin E: evidence for alternative splicing In the course of analysing the expression of the cyclin E gene in different cell lines we observed a second minor RNA species that was slightly smaller than the major RNA representing the previously described cyclin E (Koff et al., 1991). This shorte ...
View/Open - eDiss - Georg-August
... and its function in the development of the cerk1-4 phenotype. Arabidopsis accessions were found to vary regarding the abundance of the shed CERK1 ectodomain. The presence of prolines within the extracellular stalk of CERK1 positively correlated with ectodomain abundance. CERK1 variants lacking speci ...
... and its function in the development of the cerk1-4 phenotype. Arabidopsis accessions were found to vary regarding the abundance of the shed CERK1 ectodomain. The presence of prolines within the extracellular stalk of CERK1 positively correlated with ectodomain abundance. CERK1 variants lacking speci ...
DORNRÖSCHEN is a direct target of the auxin response factor
... probably relate to a secondary non-cell-autonomous signal downstream of DRN. The DRN::GFP transcriptional reporter and the DRN::DRN-GFP translational fusion were expressed throughout the 2-, 4-, 8- or 16cell embryo proper (Fig. 1B-G). From the 32-cell stage onwards, DRN::GFP expression was no longer ...
... probably relate to a secondary non-cell-autonomous signal downstream of DRN. The DRN::GFP transcriptional reporter and the DRN::DRN-GFP translational fusion were expressed throughout the 2-, 4-, 8- or 16cell embryo proper (Fig. 1B-G). From the 32-cell stage onwards, DRN::GFP expression was no longer ...
Matching catalytic activity to developmental function: Tolloid
... the imaginal discs; however, the tlr transcript is much more abundant. Despite several studies, the biological function(s) of Tlr remain ill defined. Embryos mutant for tlr show no significant defects in dorsal patterning, although it has recently been demonstrated that the level of Sog protein pres ...
... the imaginal discs; however, the tlr transcript is much more abundant. Despite several studies, the biological function(s) of Tlr remain ill defined. Embryos mutant for tlr show no significant defects in dorsal patterning, although it has recently been demonstrated that the level of Sog protein pres ...
Interrelations between translation and general mRNA degradation in
... Department of Molecular Biology, Umeå University, Umeå, Sweden Conflict of interest: The authors have declared no conflicts of interest for this article. ...
... Department of Molecular Biology, Umeå University, Umeå, Sweden Conflict of interest: The authors have declared no conflicts of interest for this article. ...