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Gene Mutation Story -Alzheimer’s It was just a typical day in the brain, no different than it always was, all cells seemed to be in order working in tip top shape, blood was being pumped through the brain, and the host William who was 60 years old was sound asleep. But there was a subtle disturbance in the brain, no one ever thought anything about it. But what was to come was more than anyone could have ever imagined… Beep! Beep! Beep! “Uhhh, just five more minutes,” says the Bob, Bob is a cell inside the Hippocampus in the Temporal Lobe located in the brain. Bob contributes to the area of the brain which is used for storing memories and creating memories. As Bob starts his day he gets out of bed goes downstairs and enjoys some “brain food” after he is through he takes his place in the Hippocampus. As Bob gets to work he quickly notices that somethings have changed, he looks around as other cells have noticed the same thing. The whole brain is in shock but can’t figure out what the problem actually is until… “ITS THEM, THE ALZHEIMERS CELLS!” screams Bob, “I thought they were just a rebind legend!” the others cells scream in terror. “HAH! We are here to infect this brain of the most common form of dementia, Alzheimer’s” says the Alzheimer’s cells. The Alzheimer’s cells start to infect the brain section, by section slowly taking over the 3 main parts of the brain: The Frontal Lobe, Temporal Lobe, and Parietal Lobe. “What’s going to happen to our host William?!” Bob asks. “well, we will kill all of his brain cells making the tissues have fewer nerve cells, and the connections between the neurons (nerve cells) which send messages to the other parts of the body weakened! HA! We will deposit protein and fibers into this brain that will stop Williams cells from ever working the same again!” the Alzheimer’s gene explains. “Then were just going to have to fight you off!” says Bob, “HA! Not a chance that will be happening because there is no way to fight us off! We will stay in Williams' brain for the rest of his life!” says the Alzheimer’s gene. “Darn! Then what can we do?” asks Bob. “Like I said before there is no cure! There are however 3 types of medicine that William can take: Aricept, Razadyne, and Exelon, but these will not cure our disease! Because we are INVINSIPAL!” the Alzheimer’s disease answered. “NOOOOO!” Bob yells. Slowly William is beginning to be affected by the Alzheimer’s disease forgetting things from time to time, but always seeming to be back to normal after a short amount of time, but as William gets older the Alzheimer’s only gets worse. After a while, William begins to develop other mental problems, and can’t seem to complete the simplest of tasks due to forgetting where he put stuff, and generally what he was doing in the first place. William will eventually experience total memory loss and not be able to recover. There are a few reasons why William may have been diagnosed with Alzheimer’s: the first being his age, Alzheimer’s generally affect 5% of people over the age of 65 years old, but there is also a possibility of this happening to people at the age of 30-40 which is known as “early onset” Alzheimer's disease which is very uncommon. Another reason why William may have been diagnosed was because this disease could have possibly been running in his family. William could have a direct link to an inherited mutation in one gene, which is more commonly found in “early onset” Alzheimer’s. Sadly, after being affected by this disease people only tend to live 8-10 years, but there are many cases of survival but with many functional problems. As William starts to forget things more regularly it becomes a problem and a danger for him living in his own home. William forgets things such as names of his family members, where he left things and the most dangerous thing leaving the stove on. While cooking with the stove William takes a break as he waits for his food to cook without leaving a timer, or reminder. William then begins to feel tired and decides to head to bed, meanwhile, his food sets on fire, spreading everywhere and eventually his house begins to burn down. William thankfully wakes up as he was being carried out by a fireman to safety. Going through this dramatic experience causes William to seek help, eventually finding himself living in a nursing home for the rest of his days.