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Chapter 4 Cellular Metabolism Metabolism: Metabolic reactions are of two types: in __anabolic___ reactions, larger molecules are constructed from smaller ones. In __catabolic __ reactions, larger molecules are broken down into smaller ones. The reactions of metabolism are often reversible Which process requires energy? anabolic Which process releases energy? Catabolic The process of joining two molecules by removing water is called __dehydration synthesis_ The process of splitting two molecule by adding water is called __hydrolysis__ Control of metabolism: ____enzymes___control the rates of all the metabolic reactions of the cell Enzymes are complex __proteins__that function to lower the activation energy of a reaction so it may begin and proceed more _rapidly_. Because they do this, enzymes are called _catalysts___. The substances the enzymes act on are called ___substrates. Each enzyme is specific. List 3 factors that may alter the action of an enzyme. Concentration of enzyme, concentration of substrate, temperature Energy: ATP is ___adenosine tri-phosphate_. It stores the energy for every reaction in the body. Where exactly is this energy stored in the ATP molecule? High chemical energy bonds Cellular Respiration: is the process that releases the energy in the chemical bonds of the energy nutrients and stores it in molecules of ATP. It has 3 basic stages, each of which have several steps and are controlled by many enzymes. The first stage does not require oxygen and so is said to be ___anaerobic____. The other two stages require oxygen and therefore are __aerobic__. The anaerobic respiration stage is called __glycolysis_. Where does it take place? What chemical does it start with? Glucose Are any ATP’s formed? Yes (2 ATP) In the cytoplasm What chemical does it end with? Pyruvate aerobic respiration has two stages. What are they called? Kreb’s cycle and Electron transport chain Where do they occur? In the mitochondria What are the three end products of this process? Water, carbon dioxide, and energy Are any ATP’s formed in aerobic respiration? Yes If so, how many? Total of 36 or 38 per glucose lipids & protein pathways – these two nutrients can be used to make ATP. Where they “plug into” the process is going to depend on how many Carbons are in the piece the cell is working on. How many ATPs formed will also depend on this. Nucleic Acids: DNA & RNA Deoxyribonucleic acid (DNA) contains the __genet__ code needed for the synthesis of each _protein__ (including enzymes) required by the cell. What is the sugar in DNA called? deoxyribose Name the four bases. Adenine, thymine, cytosine, guanine What are the two base complementary pairs of DNA? Adenine – thymine: Cytosine - guanine DNA is double strands and twists to form a __double helix_ The sequence of nucleotides in a DNA molecule gives the sequence of amino acids for a given protein. Messenger RNA (mRNA) copy and transfer the genetic information to the cytoplasm where proteins are manufactured. 1 What is the sugar in RNA called? ribose Name the four bases: adenine, cytosine, guanine, uricil What are the three types of RNA called? Messenger RNA, transfer RNA, ribosomal RNA Protein Synthesis: _messenger_RNA molecules copy part of the DNA code in the nucleus. They then travel to the _cytoplasm__ where protein synthesis will occur. They lie across the __ribosome_ and wait for the ___transfer RNA to bring in the appropriate amino acids. The correct amino acids will be lined up because the tRNA bases are arranged in _anti-codons_ that are complementary to the __cocons_ of the bases of the mRNA. The amino acids bond with peptide bonds to each other to form a protein. DNA Replication: Each new cell must be provided with an exact replica of the parent cell's DNA. When does DNA replication occur? During interphase The DNA molecule splits. Nucleotides form ___complementary_pairs with the original strands. Each new DNA molecule consists of one parental strand and one newly synthesized strand of DNA. What is a mutation? An alteration in the genetic code within a gene How might it affect the protein being produced from it? The protein will probably not function correctly 2