* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Lecture Chpt. 16 DNA 1
Zinc finger nuclease wikipedia , lookup
Epigenetics wikipedia , lookup
DNA paternity testing wikipedia , lookup
Nutriepigenomics wikipedia , lookup
Mitochondrial DNA wikipedia , lookup
Comparative genomic hybridization wikipedia , lookup
DNA barcoding wikipedia , lookup
Designer baby wikipedia , lookup
SNP genotyping wikipedia , lookup
DNA profiling wikipedia , lookup
DNA polymerase wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
Genomic library wikipedia , lookup
Primary transcript wikipedia , lookup
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing wikipedia , lookup
Cancer epigenetics wikipedia , lookup
Bisulfite sequencing wikipedia , lookup
Point mutation wikipedia , lookup
Gel electrophoresis of nucleic acids wikipedia , lookup
Genetic engineering wikipedia , lookup
DNA damage theory of aging wikipedia , lookup
Genealogical DNA test wikipedia , lookup
United Kingdom National DNA Database wikipedia , lookup
Epigenomics wikipedia , lookup
Cell-free fetal DNA wikipedia , lookup
Non-coding DNA wikipedia , lookup
Artificial gene synthesis wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
DNA vaccination wikipedia , lookup
Molecular cloning wikipedia , lookup
Microevolution wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
DNA supercoil wikipedia , lookup
Nucleic acid double helix wikipedia , lookup
Helitron (biology) wikipedia , lookup
Cre-Lox recombination wikipedia , lookup
Extrachromosomal DNA wikipedia , lookup
Nucleic acid analogue wikipedia , lookup
Chpt. 16 Molecular Basis of Inheritance 1920’s Traits are inherited on 1920’s But what makes up the genetic material?? DNA or 1928 Fredrick Griffith Research organism: Streptococcus Two strains: Pathogenic (S) Harmless (R) S = :-( R = :-) + h e a t + h e a t :-) + + + :-( + Something from the dead cells, caused the good cells to change into bad Transformation We now know transformation to be the assimilation of DNA by a cell… Transformation You will do this in AP Bio lab #6B Transformation 1944 Oswald Avery What was transforming Hershey & Chase 1952 Hershey & Chase 1952 How did this virus reprogram its host? Made of only: Protein & DNA 1952 Hershey & Chase--> *“tagged” 2 parts of bacteriophage - protein (w/ S) and DNA (w/ P). 1952 Hershey & Chase--> *Radioactive phosphate found inside phage. DNA IS GENETIC MATERIAL NOT PROTEIN!! Picture Proof Erwin Chargoff 1947 - Bases are present in a characteristic ratio. A:T C:G •N •DNA ratio varies from species to species. A, T, G, C PURINES two organic PYRIMIDINES one organic ring James WATSON & Francis CRICK Rosalind Franklin http://www.pbs.org/wgbh/nova/p hoto51/ Structure of DNA?? DNA Backbone • Polymer of sugarphosphate. • 2 backbones present. DNA Backbone • Polymer of sugarphosphate. • 2 backbones present. Nitrogen Bases • Bridge the backbones together. • Purine + Pyrimidine = 3 rings. • Constant distance between the 2 backbo • Held together by H-bonds. Two H bonds Three H bonds 10 base pairs per twist. A=T G C 2 H bonds A:T 3 H-bonds G:C www.perfectdna.com/products.htm QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. DNA ART http://www.dna11.com/ “It has not escaped our notice that the specific pairing we have postulated immediately suggests a a possible copying mechanism for genetic Dear mama and papa, you are nice I like you I like Christmas. I cant wait to see you. LOVE Erica (and Will.) Ages 6 and 8.