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Cambridge Biology for the IB Diploma Scheme of work for Chapter 7, Nucleic acids and proteins Syllabus section Content Time required Outline of lesson content Coursebook resources Worksheets Teacher’s resources / Teaching ideas 7.1 DNA structure 1–2 lessons Recall the structure of DNA and extend the detail to include descriptions of antiparallel strands, 3'–5' linkages and hydrogen bonding; describe the structure of nucleosomes and their importance in supercoiling p170–172 Extension: Q2 Practical activity: modelling of DNA structure Distinguish between unique and repetitive sequences in DNA and state the difference between exons and introns 7.2 7.3 DNA replication Transcription 2 lessons 2 lessons Shortanswer Qs p172 Support: Q1, Q2 TOK p172 Exemplar exam questions: MCQs End-ofchapter Qs p189–193: Q1, Q2, Q10 Explain the process of DNA replication and the role of enzymes and formation of Okazaki fragments; state that replication occurs in a 5'– 3' direction and is initiated at many points in eukaryotes p173–175 Explain the process of transcription in prokaryotes including the roles of the promoter region, RNA polymerase, nucleoside triphosphates and the terminator; state that transcription occurs in a 5'–3' direction and that the antisense strand is transcribed p175–177 Shortanswer Qs p175 Link to Chapter 3 Support: Q2, Q3, Q4 Practical activity: video clips Exemplar exam questions: MCQs End-ofchapter Qs p189–193: Q3 End-ofchapter Qs p189–193: Q4 Extension: Q2, Q3 Practical activity: video clips Support: Q5 Exemplar exam questions: MCQs Extension: Q4 Exemplar exam questions: MCQs Introns must be removed from eukaryotic RNA to form mature mRNA 7.4 Translation 2 lessons Outline the structure of tRNA and explain that each tRNA has a specific activating enzyme that binds a specific amino acid; identify the four stages of translation and state that it occurs in a 5'– 3' direction p177–181 Shortanswer Qs p181 End-ofchapter Qs p189–193: Q5, Q8 Explain the process of translation including the roles of ribosomes, polysomes and start and stop codons; draw a peptide bond between two amino acids and state that free ribosomes synthesize protein for use in the cell Copyright Cambridge University Press 2011. All rights reserved. Page 1 of 2 Cambridge Biology for the IB Diploma 7.5 7.6 Proteins Enzymes 1 lesson 2 lessons Explain the four levels of protein structure; outline the structure of fibrous and globular proteins giving four examples and their functions; explain the significance of polar and non-polar amino acids in proteins p182–185 Describe the induced-fit model for enzyme action; explain that enzymes lower activation energy of reactions and that metabolic pathways consist of chains of enzyme-catalysed reactions p185–189 End-ofchapter Qs p189–193: Q6 Extension: Q1 Practical activity: 3D modelling of protein structure Link to ICT: simulations Exemplar exam questions: Q1 Shortanswer Qs p189 End-ofchapter Qs p189–193: Q7, Q9, Q11 Explain competitive and non-competitive inhibition and explain how metabolic pathways are controlled by end-product inhibition and allosteric sites Extension: Q5 Support: Q6 Link with Chapter 3 – opportunity for assessed practical on enzyme activity Link to TOK: development of induced-fit hypothesis Link to ICT: data logging Exemplar exam questions: MCQs Note: 1 lesson = approximately 40 minutes Copyright Cambridge University Press 2011. All rights reserved. Page 2 of 2