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Biotechnology Lesson Plans for Advanced Placement Biology Prior Learning: DNA structure and replication Central Dogma Control of Gene Expression Mutation and Disease/ Mutation and Cancer Day Student Activities 1 Biotechnology PPT And Microarray Show Homework: SNP Analysis and Pharmacogenics Paper Activity Resources A PPT is available on Wise’s website: http://pages.cms.k12.nc.us/andreawise/apbiology.html “Biotechnology for AP” SNP Analysis Paper Activity http://gslx.genetics.utah.edu Click Teach Genetics (Top right) Search SNP Analysis and Pharmocogenics Also View http://learn.genetics.utah.edu/content/labs/microarray/in dex.html 2 3 EPIGENICS Nova Video “Ghost in Your Genes” Begin Paper Lab from “DNA CHIPS” Due: SNP Analysis CUSTOMIZED MEDICINEPHARMACOGENICS Complete Carolina Kit “DNA Chips: Genes to Disease Lab Kit” Paper Lab and Simulation Alternatively: Ghost in Your Genes Microarray Simulation Video: “Ghost in Your Genes” Nova, 56 minutes There is a teacher’s guide for this: www.pbs.org/nova/genes For ordering kits: http://www.carolina.com #211520 DNA CHIPS: Genes to Disease Lab Kit For Dr. Sharon Bullock’s Customized Medicine Power Point go to http://pages.cms.k12.nc.us/andreawise/apbiology.html And click “Customized Medicine Link” Ghost in Your Genes Simulation http://www.pbs.org/wgbh/nova/teachers/programs/3413 _genes.html 4 RELATED ISSUES Complete and Debrief Previous Information Discussion: Genetic Screening Here are some articles and a curriculum to guide a discussion about genetic screening: http://www.affymetrix.com/about_affymetrix/outreach/ed ucator/microarray_curricula.affx 5 6 7 8 9 NEXT UNIT TRANSFORMATION Lab 6 PreLab Paper Plasmid Lab (Break out groups: Practice using micropipette and loading wells) TRANSFORMATION Lab 6 Plasmid Lab GEL ELECTROPHORESIS APPLICATION Forensic Lab (Outbreak) in addition to AP Lab 6 Lab Questions Completed in Class Review all Biotech AP Lab Manual: Lab 6 Ward’s Natural Science Has a straightforward Plasmid Lab AP Lab 6 #88 V 8231 Any transformation will work. Connie Wood (East Meck) suggests using Carolina Biological’s “Outbreak” activity. She gets free DNA for this. TEST—GENE EXPRESSION, CANCER, BIOTECHNOLOGY In the Evolution Unit Molecular Scientific American “Founder Mutations” October 2005 Genetics will be used in teaching Includes molecular evidence of evolution, Haplotypes, Mutations, Genetic Recombination, making molecular clocks, and in Customized Medicine, Decent from Africa Founder Mutations Other Helpful Links: BioRad has Lessons and Power Points www.explorer.bio-rad.com