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Transcript
Name: _________________________________ Per: ______ DNA WebQuest Part A: DNA Replication DNA Workshop – Replication and Protein Synthesis 1. Go to www.pbs.org/wgbh/aso/tryit/dna 2. Click “text version of activity” 3. Then click on “DNA Replication”, “All Wound Up” and “Protein Synthesis” as needed. During what part of the cell cycle does DNA get replicated? _________________________________ Unzip the DNA. What kind of bonds are broken as the DNA “unzips”? ____________________________________ What breaks the rungs of the DNA ladder? ___________________________________________ Where in the cell does DNA replication take place? __________________________________ Which nitrogenous base does each of the following letters in the DNA molecule represent? A _______________________________ C _______________________________ G _______________________________ T _______________________________ Match the bases to make two new DNA strands. Which nitrogenous base does each of the following letters in the DNA molecule pair with? A _______________________________ C _______________________________ G _______________________________ T _______________________________ How many base pairs does the Human Genome contain? _________________________________ How many complete molecules of DNA do you begin with in DNA replication? _________________ How many DNA molecules do you end up with? ________________________ Is the new DNA molecules completely new? Explain. _____________________________________ ____________________________________________________________________________________ 1. Go to http://nobelprize.org/educational_games/medicine/dna_double_helix/ 2. Click on “Play DNA Game”; Click “next” and reading each page, continue to click next until you come to the game.; Click on organism #1 and match the base pairs as fast as you can! It is hard. 3. Click Next and then click on each organism until you identify the one that belongs to chromosome #1; continue playing the game with the other two chromosomes, filling in the chart below. Be careful, other people may get different results. Chromosome # 1 2 3 How many chromosomes? How many base pairs? How many genes? What is the organism? Part B: DNA Transcription and Translation From Gene to Protein 1. Go to http://learn.genetics.utah.edu/content/begin/dna/transcribe/ 2. Press “Click here to begin!” What is the two-step process by which cells read a gene and produce a string of amino acids that will eventually become a protein is called: ____________________ and ______________________ How are rules for pairing bases different in transcription than they were in replication? ___________ ____________________________________________________________________________________ How many genes does the Human Genome contain? _______________________________________ Use the keyboard to type in the corresponding base pairs to transcribe the section of DNA. Describe transcription in your own words. _______________________________________________ ____________________________________________________________________________________ How is mRNA different from DNA? _____________________________________________________ ____________________________________________________________________________________ What happens to DNA after transcription is complete? _____________________________________ Translate the mRNA into a protein. Describe translation in your own words. _________________________________________________ ____________________________________________________________________________________ What is the correct starting position on mRNA for translation? ______________________________ Write the amino acids used to assemble your protein in order below. _________________________ ____________________________________________________________________________________ Where does translation take place? _____________________________________________________ Once assembled, what is the key to a protein’s unique function? ____________________________ 1. Go to: http://www.wisc-online.com/objects/index_tj.asp?objid=AP1302 2. Read the animation page by page – just click the “next” button when you are ready to move on. How does the mRNA leave the nucleus? __________________________________________________ Is just one mRNA molecule made? Explain.________________________________________________ ____________________________________________________________________________________ How many amino acids does each codon code for?____________________ Describe the structure of a tRNA molecule. ____________________________________________ ____________________________________________________________________________________ Can a single mRNA be read more than once? Explain. _______________________________________ ____________________________________________________________________________________ Part C: Mutations 1. Go to http://evolution.berkeley.edu/evolibrary/article/mutations_01 2. In your own words, describe each type of mutation: Substitution: ____________________________________________________________________ Insertion: ____________________________________________________________________ Deletion: _______________________________________________________________________ Frameshift: _____________________________________________________________________ Deletion: _____________________________________________________________________ What causes a mutation? The effects of mutations Where may mutations occur? What are somatic mutations? What are the effects of germ line mutations? 1. 2. 3. What are Hox genes? What is the effect of a mutation in the Hox gene? Weird Fact: What happened to the fly with a H ox mutation? Part D: EXTRA CREDIT Go to http://learn.genetics.utah.edu/content/begin/dna/firefly/ Explain What Makes a Firefly Glow in your own words, using all of the words below: RNA Polymerase LUC gene Transcription mRNA Luciferase Enzyme Ribosome Translation Amino Acids Three dimensional Luciferin Oxyluciferin Functional Luciferase Enzyme ____________________________________________________________________________________ ____________________________________________________________________________________ ____________________________________________________________________________________ ____________________________________________________________________________________ ____________________________________________________________________________________ ____________________________________________________________________________________
