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Transcript
Phenotype to genotype in Nasonia and beyond Christopher Desjardins The Broad Institute Cambridge, MA The insect genetic model Nasonia Genus of fly parasitoid with diverse phenotypes N. vitripennis N. longicornis N. giraulti N. oneida Diverse resources: genome, genetic map, RNAi Nasonia: phenotype to genotype Morphology Phenotype Genotype Behavior Reproductive x 47% survival x 18% survival Drawing from Drosophila st-318: red eye mutant = cinnabar gene As our model organisms diversify the need to relate a broad range of phenotypes across them grows What do I do now? • Bioinformatics scientist at the Broad Institute • Assist biologists in the interpretation of genomic data – Comparative genomics – Functional annotation – High throughput transcriptional profiling • The number one question of most biologists involved in a genome sequencing project is how to link phenotype to genotype
