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A survey on computational methods for enhancer and
A survey on computational methods for enhancer and

... and their target promoters is 124kb (Jin et al. 2013). All these flexibility in enhancer location makes them much harder to identify than some other types of sequence elements, such as promoters, which are right upstream of the target genes. Second, up to now, no single features or combinations of f ...
Introduction - Stellenbosch University
Introduction - Stellenbosch University

... • explain the scope of bioinformatics • describe web-based versus command-line approaches to bioinformatics. • define the types of molecular databases • define accession numbers and the significance of RefSeq identifiers • describe the main genome browsers and use them to study features of a genomic ...
Ensembl variation resources Open Access Database
Ensembl variation resources Open Access Database

... Furthermore, potential variants are filtered and discarded if they have more than 30 mismatches from a single sequence read or are in a region with more than 100 aligned reads. (These values are reduced if the sequencing coverage is less than approximately 0.1×). Read pair information is used to fil ...
Alu
Alu

... Fig.1. (a) Number of Alu repeats in different chromosomes in human genome with vertical segments representing the numbers corresponding to each Alu ...
genomebiology.com
genomebiology.com

... exons/introns from previously intronic/exonic sequences, respectively), and insertion into first and last exons. However, no extensive analysis has compared the effects of TEs on the transcriptomes of mammals, non-mammalian vertebrates and invertebrates. Results: We analyzed the influence of TEs on ...
Application of whole genome sequencing to fully characterise
Application of whole genome sequencing to fully characterise

Genomic Databases for Tomato
Genomic Databases for Tomato

... and are available online. Sequence comparisons allow us to identify tomato genes that have no orthologue (counterpart) in these plants. Information on such tomato genes facilitates elucidation of gene functions and metabolic pathways that are characteristic of tomato and the Solanaceae family. Infor ...
RNA-Seq Analysis Practicals
RNA-Seq Analysis Practicals

... • Down-weight very low or high values ...
Approaches to Repeat Finding
Approaches to Repeat Finding

... Cornell Genomics Forum, 2005-03-18 ...
Alu - Environmental
Alu - Environmental

... • Alu elements are only found in the primate branch • Each Alu insertion is a unique event and is inherited from each parent • Most occurred millions of years ago and are often on both pairs of chromosomes • There are Alu elements that have occurred since humans branched from other primates • This g ...
D. melanogaster - GEP Community Server
D. melanogaster - GEP Community Server

... RAMPAGE = RNA Annotation and Mapping of Promoters for Analysis of Gene Expression CAGE only allows sequencing of short sequence tags (~27 bp) near the 5’ cap Ambiguous read mapping to large parts of the genome ...
Application Note: Targeted sequencing and chromosomal haplotype
Application Note: Targeted sequencing and chromosomal haplotype

... Each individual TLA template contains fragments that may be ten to hundreds of kilobases apart in base space, but are all close enough to be cross-linked. Because it is not a targeted approach, this strategy results in long range information that covers the entire genome. ...
Functional Annotation
Functional Annotation

Statistical analysis of simple repeats in the human genome
Statistical analysis of simple repeats in the human genome

... Experiments on kinetics of DNA denaturation and renaturation and the analysis of DNA sequences have revealed that most of our genome is populated by DNA repeats of different length, number and degree of dispersion [1]. Long repeats in few copies are usually orthologous genes, which may contain hidde ...
Structural Variants in the Human Genome
Structural Variants in the Human Genome

... genomes and they are a major cause of phenotypic variation • They are common in certain diseases, particularly cancers and behavioral diseases • They are now also showing up in rare diseases and common behavioral diseases such as autism, schizophrenia and many neurological disorders Courtesy of Mike ...
here - enigma
here - enigma

... Members of the ENIGMA Consortium include investigators from different centers around the world who are actively engaged in genetics and neuroimaging research and who have contributed results from primary analyses of imaging, genetic data, and/or algorithm development for the purpose of meta-analysis ...
Discovery and characterization of chromatin states for Please share
Discovery and characterization of chromatin states for Please share

... provide a valuable resource for interpreting biological and medical datasets, such as genome-wide association studies for diverse phenotypes, and potentially pinpointing novel classes of functional elements. ...
Horizontal transfer of non-LTR retrotransposons: artifact or rare event
Horizontal transfer of non-LTR retrotransposons: artifact or rare event

Alu Human Polymorphism
Alu Human Polymorphism

... • Each Alu insertion is a unique event and is inherited from each parent – Most occurred millions of years ago and are often on both pairs of chromosomes – There are Alu elements that have occurred since humans branched from other primates – This gives rise to dimorphic Alus from the last hundreds o ...
Agilent Whole Human Genome Oligo Microarray Kit
Agilent Whole Human Genome Oligo Microarray Kit

... Designed to truly represent the known genes in the human genome and their resulting transcripts, Agilent’s Whole Human Genome Oligo microarray is comprised of approximately 41,000 (60-mer) oligonucleotide probes, which span conserved exons across the transcripts of the targeted full-length genes. Th ...
Potential of promotion of alleles by genome editing for improving
Potential of promotion of alleles by genome editing for improving

... Overall hypothesis of GS2.0 • Sequence data has huge potential in livestock and plant breeding • Huge volumes of sequence needed to realize ...
PDF
PDF

... December 2001 golden path freeze of the human genome, which is also NCBI build 28, with each mouse assembly. We first used RepeatMasker (A. Smit, unpublished work, and [7]), to mask the repeats in all the three genomes. With a fixed expect value (E-value) of 1.0e-1 we found 1,860,560 conserved seque ...
ChromatinDB: a database of genome-wide
ChromatinDB: a database of genome-wide

... Grunstein, 2006). Histone modifications are directed to specific regions of the genome by histone modifying enzymes, and can act to both repress and activate gene transcription. Recently, a new experimental methodology coupling chromatin immunoprecipitation (ChIP) assays with DNA microarray technolo ...
What`s in a Genotype? - CEUR Workshop Proceedings
What`s in a Genotype? - CEUR Workshop Proceedings

... down into reference and variant components, the genomic variation complement can be further decomposed into one or more variant single locus complements, representing the set of all complementary loci where at least one variant exists (Figure 1B). This complement is typically a pair of sequences for ...
Gene regulation in three dimensions
Gene regulation in three dimensions

... Last, but not least I would like to thank Julie my fiancé who has supported me and been there for me when I needed it the most. K.T.W ...
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ENCODE

The Encyclopedia of DNA Elements (ENCODE) is a public research project launched by the US National Human Genome Research Institute (NHGRI) in September 2003.Intended as a follow-up to the Human Genome Project (Genomic Research), the ENCODE project aims to identify all functional elements in the human genome.The project involves a worldwide consortium of research groups, and data generated from this project can be accessed through public databases.
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