Lactose tolerance
... Lactose intolerance actually comes in three forms: 1. Primary lactose intolerance. As children are weaned they lose the ability to metabolise milk, so they become lactose-intolerant adults. 2. Secondary lactose intolerance. This occurs in adults from lactose tolerant populations who, due to damage ...
... Lactose intolerance actually comes in three forms: 1. Primary lactose intolerance. As children are weaned they lose the ability to metabolise milk, so they become lactose-intolerant adults. 2. Secondary lactose intolerance. This occurs in adults from lactose tolerant populations who, due to damage ...
Time to asthma onset Asthma score Bivariate analysis - Hal-CEA
... Linkage analysis of the martingale residuals was performed using the Maximum Likelihood Binomial method (Abel and Muller-Myhsok 1998; Alcais and Abel 1999), as implemented in MLB-GENEHUNTER (Abel and Muller-Myhsok 1998). As opposed to the Variance Components (VC) method, this method does not requir ...
... Linkage analysis of the martingale residuals was performed using the Maximum Likelihood Binomial method (Abel and Muller-Myhsok 1998; Alcais and Abel 1999), as implemented in MLB-GENEHUNTER (Abel and Muller-Myhsok 1998). As opposed to the Variance Components (VC) method, this method does not requir ...
Distribution and Concordance of N-Acetyltransferase Genotype and
... status varies widely between individuals and ethnic groups and has been associated with susceptibility to several cancers. Few studies have reported the distribution of NAT2 status for Caucasian-American populations or evaluated the concordance between methods of assessment for cancer cases and cont ...
... status varies widely between individuals and ethnic groups and has been associated with susceptibility to several cancers. Few studies have reported the distribution of NAT2 status for Caucasian-American populations or evaluated the concordance between methods of assessment for cancer cases and cont ...
PDF
... inference study further demonstrated that weedy rice had two dominant genomic components (temperate japonica and indica). This strongly suggests that weedy rice originated from indica-japonica hybridization. Furthermore, 22,443 novel fixed single nucleotide polymorphisms were detected in the weedy g ...
... inference study further demonstrated that weedy rice had two dominant genomic components (temperate japonica and indica). This strongly suggests that weedy rice originated from indica-japonica hybridization. Furthermore, 22,443 novel fixed single nucleotide polymorphisms were detected in the weedy g ...
24 Recombination Hotspots in Nonallelic Homologous Recombination
... the fine-mapping of all homologous recombination (HR) processes can only help our admittedly basic comprehension of what is a fundamental cellular process. In recent years there has been a growing desire to be able to use patterns of linkage disequilibrium (LD) throughout the genome to design more e ...
... the fine-mapping of all homologous recombination (HR) processes can only help our admittedly basic comprehension of what is a fundamental cellular process. In recent years there has been a growing desire to be able to use patterns of linkage disequilibrium (LD) throughout the genome to design more e ...
STATISTICS IN GENETICS
... tary) statistical genetics it is customary to use the genetic code as the explanatory variable, lumping all variations into environmental or “noise” factors. Because much about the working of a cell is still to be discovered, not all genes are known. However, based on current knowledge and structura ...
... tary) statistical genetics it is customary to use the genetic code as the explanatory variable, lumping all variations into environmental or “noise” factors. Because much about the working of a cell is still to be discovered, not all genes are known. However, based on current knowledge and structura ...
Forche et al. 2008 PLoS Biology
... amongst the Fungi imperfecti [8]. However, a robust mating system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niche ...
... amongst the Fungi imperfecti [8]. However, a robust mating system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niche ...
The Parasexual Cycle in Candida albicans Provides an
... amongst the Fungi imperfecti [8]. However, a robust mating system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niche ...
... amongst the Fungi imperfecti [8]. However, a robust mating system has now been uncovered in this organism, in which mating occurs between diploid mating type-like (MTL) a and a strains to generate an a/a tetraploid strain. Mating occurs both under laboratory conditions and in different in vivo niche ...
Revisiting the Impact of Inversions in Evolution
... Recently, molecular techniques have been developed to score known inversion polymorphisms, either through primers that span the breakpoint region of the inversions or through single nucleotide polymorphisms (SNPs) and other polymorphisms in disequilibrium with the inversions (Matzkin et al. 2005, Wh ...
... Recently, molecular techniques have been developed to score known inversion polymorphisms, either through primers that span the breakpoint region of the inversions or through single nucleotide polymorphisms (SNPs) and other polymorphisms in disequilibrium with the inversions (Matzkin et al. 2005, Wh ...
MHC, mechanisms and
... alleles were detected in populations of humans and Drosophila (Harris 1966; Lewontin & Hubby 1966), biologists have debated the relative roles of balancing selection and neutral processes in maintaining the diversity observed in wild populations (reviewed in Nei 2005). This debate has now matured, a ...
... alleles were detected in populations of humans and Drosophila (Harris 1966; Lewontin & Hubby 1966), biologists have debated the relative roles of balancing selection and neutral processes in maintaining the diversity observed in wild populations (reviewed in Nei 2005). This debate has now matured, a ...
Optimizing selection for quantitative traits with information on an
... can maximize genetic progress in the short term (i.e. in the current generation), they may not maximize response to selection in the longer term. In fact, Gibson (1994) found that traditional selection, based on phenotypic information alone, resulted in greater genetic improvement in the longer term ...
... can maximize genetic progress in the short term (i.e. in the current generation), they may not maximize response to selection in the longer term. In fact, Gibson (1994) found that traditional selection, based on phenotypic information alone, resulted in greater genetic improvement in the longer term ...
How pathogens drive genetic diversity: MHC, mechanisms and
... alleles were detected in populations of humans and Drosophila (Harris 1966; Lewontin & Hubby 1966), biologists have debated the relative roles of balancing selection and neutral processes in maintaining the diversity observed in wild populations (reviewed in Nei 2005). This debate has now matured, a ...
... alleles were detected in populations of humans and Drosophila (Harris 1966; Lewontin & Hubby 1966), biologists have debated the relative roles of balancing selection and neutral processes in maintaining the diversity observed in wild populations (reviewed in Nei 2005). This debate has now matured, a ...
Analysis of CAG and CCG repeats in Huntingtin gene
... 41–56, while the range of the normal allele on the homologous chromosome was 13–29 repeats. We noted an inverse correlation between age at presentation and CAG repeat number. In seven of the 12 HD patients with positive family history, the HD chromosome was derived paternally, while in the remaining ...
... 41–56, while the range of the normal allele on the homologous chromosome was 13–29 repeats. We noted an inverse correlation between age at presentation and CAG repeat number. In seven of the 12 HD patients with positive family history, the HD chromosome was derived paternally, while in the remaining ...
Quantitative trait locus mapping in natural populations
... 2001). The acronym QTL was first coined by Geldermann (1975). However, the underlying concept is older, having originated in the early 1900s (reviewed in Lynch & Walsh 1998). The basic premise that underlies all QTL mapping methods is straightforward. Genetic markers dispersed over an organisms’ gen ...
... 2001). The acronym QTL was first coined by Geldermann (1975). However, the underlying concept is older, having originated in the early 1900s (reviewed in Lynch & Walsh 1998). The basic premise that underlies all QTL mapping methods is straightforward. Genetic markers dispersed over an organisms’ gen ...
Genome Rearrangements ()
... • Greedy approach: 2 prefix reversals at most to place a pancake in its right position, 2n – 2 steps total at most • William Gates and Christos Papadimitriou showed in the mid-1970s that this problem can be solved by at most 5/3 (n + 1) prefix reversals ...
... • Greedy approach: 2 prefix reversals at most to place a pancake in its right position, 2n – 2 steps total at most • William Gates and Christos Papadimitriou showed in the mid-1970s that this problem can be solved by at most 5/3 (n + 1) prefix reversals ...
Effect of population size, selection intensity, linkage and non
... long have had formulations for selection without epistasis and for the effects of linkage on the approach to equili brium under random mating without selection, but no one has been able, mathematically, to derive valid equations for selection in finite populations in the presence of linkage and epi ...
... long have had formulations for selection without epistasis and for the effects of linkage on the approach to equili brium under random mating without selection, but no one has been able, mathematically, to derive valid equations for selection in finite populations in the presence of linkage and epi ...
Inference of homologous recombination in bacteria using whole
... tutions higher than expected through mutation alone, and will miss events that introduce fewer changes [13]. There are also other signals of recombination, most importantly homoplasy which occurs when segregating nucleotides at pairs of sites are not consistent with a single tree [17]. That signal ...
... tutions higher than expected through mutation alone, and will miss events that introduce fewer changes [13]. There are also other signals of recombination, most importantly homoplasy which occurs when segregating nucleotides at pairs of sites are not consistent with a single tree [17]. That signal ...
Pleiotropic effects of methoprene-tolerant (Met), a gene involved in
... these traits. The allelic effects of Met support genetic models where pleiotropy at genes associated with hormone regulation can contribute to the evolution of life history traits. ...
... these traits. The allelic effects of Met support genetic models where pleiotropy at genes associated with hormone regulation can contribute to the evolution of life history traits. ...
Tapanes-Castillo A, Weaver EJ, Smith RP, Kamei Y, Caspary T, Hamilton-Nelson KL, Slifer SH, Martin ER, Bixby JL, Lemmon VP. Neurogenetics. 2012 Feb;11(1):53-71. A modifier locus on chromosome 5 contributes to L1 cell adhesion molecule X-linked hydrocephalus in mice.
... mice. The cross was set up in this manner because male and female B6.Cg-L1-6D mutants are poor breeders. An intercross was then set up between F1 L1-6D/Y males and heterozygous or homozygous F1 L1-6D females to generate F2 progeny. Mice were euthanized with carbon dioxide and evaluated for hydroceph ...
... mice. The cross was set up in this manner because male and female B6.Cg-L1-6D mutants are poor breeders. An intercross was then set up between F1 L1-6D/Y males and heterozygous or homozygous F1 L1-6D females to generate F2 progeny. Mice were euthanized with carbon dioxide and evaluated for hydroceph ...
LINKAGE RELATIONS OF AUTOSOMAL FACTORS IN
... satisfactory preparations for study and the rather large number of very small c romosomes. Whether there are 16 or 39 pairs of chromosomes in the chicken will not make too much difference to the geneticist since even the smallest proposed number makes the problem of complete mapping a complicated on ...
... satisfactory preparations for study and the rather large number of very small c romosomes. Whether there are 16 or 39 pairs of chromosomes in the chicken will not make too much difference to the geneticist since even the smallest proposed number makes the problem of complete mapping a complicated on ...
1999 Dekkers: BREEDING IN THE 21st CENTURY
... of quantitative genetics (Kuhn et al; 1997; Fournet et al. l’997). All these studies, however, assumed the effect of the g’ene was known, compared selection on the QTL to selection on theanimal’s own phenotype, and assumed phenotype was observed on all animals. Other studies have removed one or more ...
... of quantitative genetics (Kuhn et al; 1997; Fournet et al. l’997). All these studies, however, assumed the effect of the g’ene was known, compared selection on the QTL to selection on theanimal’s own phenotype, and assumed phenotype was observed on all animals. Other studies have removed one or more ...
Translation of Drug Metabolic Enzyme and Transporter (DMET) Genetic Variants into Star Allele Notation using SAS.
... then the chromosome has the CYP4B1*3 allele. The star allele provides a description of one copy of the patient’s gene. It is useful to think of the star alleles as vectors and the variants as vector components (i.e. dimensions or fields). Table 3 lists variants as fields and star alleles are defined ...
... then the chromosome has the CYP4B1*3 allele. The star allele provides a description of one copy of the patient’s gene. It is useful to think of the star alleles as vectors and the variants as vector components (i.e. dimensions or fields). Table 3 lists variants as fields and star alleles are defined ...
TaqMan® SNP Genotyping Assays User Guide
... Additional SNP present under the probe or primer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Gene has a copy number polymorphism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SNP is triallelic or tetra-allelic . . . . . . . . . . . . . . . . . . . . . . . ...
... Additional SNP present under the probe or primer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Gene has a copy number polymorphism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SNP is triallelic or tetra-allelic . . . . . . . . . . . . . . . . . . . . . . . ...
Document
... Insight into Human Genetic Disorder • Waardenburg’s syndrome is characterized by pigmentary dysphasia • Gene implicated in the disease was linked to human chromosome 2 but it was not clear where exactly it is located on chromosome 2 ...
... Insight into Human Genetic Disorder • Waardenburg’s syndrome is characterized by pigmentary dysphasia • Gene implicated in the disease was linked to human chromosome 2 but it was not clear where exactly it is located on chromosome 2 ...
Parallel Evolution of Copy-Number Variation across Continents in
... distance from the equator; that is, if allele A is at higher frequency in Maine, is this allele also at higher frequency in Tasmania? Of the 190 CNVs differentiated in the United States, 65 are also differentiated in the same direction with respect to latitude on both continents (fig. 3a; P < 2.2 ...
... distance from the equator; that is, if allele A is at higher frequency in Maine, is this allele also at higher frequency in Tasmania? Of the 190 CNVs differentiated in the United States, 65 are also differentiated in the same direction with respect to latitude on both continents (fig. 3a; P < 2.2 ...
Tag SNP
A tag SNP is a representative single nucleotide polymorphism (SNP) in a region of the genome with high linkage disequilibrium that represents a group of SNPs called a haplotype. It is possible to identify genetic variation and association to phenotypes without genotyping every SNP in a chromosomal region. This reduces the expense and time of mapping genome areas associated with disease, since it eliminates the need to study every individual SNP. Tag SNPs are useful in whole-genome SNP association studies in which hundreds of thousands of SNPs across the entire genome are genotyped.