* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Harris presentation
Epigenetics of neurodegenerative diseases wikipedia , lookup
Zinc finger nuclease wikipedia , lookup
Transposable element wikipedia , lookup
No-SCAR (Scarless Cas9 Assisted Recombineering) Genome Editing wikipedia , lookup
Human genome wikipedia , lookup
Saethre–Chotzen syndrome wikipedia , lookup
Protein moonlighting wikipedia , lookup
Non-coding DNA wikipedia , lookup
Copy-number variation wikipedia , lookup
Genetic engineering wikipedia , lookup
Genomic library wikipedia , lookup
Genome (book) wikipedia , lookup
Neuronal ceroid lipofuscinosis wikipedia , lookup
Point mutation wikipedia , lookup
Gene therapy of the human retina wikipedia , lookup
History of genetic engineering wikipedia , lookup
Public health genomics wikipedia , lookup
Gene expression profiling wikipedia , lookup
Epigenetics of diabetes Type 2 wikipedia , lookup
Gene therapy wikipedia , lookup
Gene expression programming wikipedia , lookup
Human Genome Project wikipedia , lookup
Gene desert wikipedia , lookup
Pathogenomics wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
Nutriepigenomics wikipedia , lookup
Gene nomenclature wikipedia , lookup
Microevolution wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
Helitron (biology) wikipedia , lookup
Genome evolution wikipedia , lookup
Designer baby wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Scope of the Gene Ontology Vocabularies GO Project Goals: • Compile structured vocabularies describing aspects of molecular biology • Describe gene products using vocabulary terms (annotation) • Develop tools: • to query and modify the vocabularies and annotations • annotation tools for curators DAG Structure Directed acyclic graph: each child may have one or more parents The True Path Rule Every path from a node back to the root must be biologically accurate Relationship Types • is-a subclass; a is a type of b • part-of physical part of (component) subprocess of (process) The Three Ontologies •Molecular Function — elemental activity or task nuclease, DNA binding, transcription factor •Biological Process — broad objective or goal mitosis, signal transduction, metabolism •Cellular Component — location or complex nucleus, ribosome, origin recognition complex The Three Ontologies •Molecular Function — elemental activity or task nuclease, DNA binding, transcription factor •Biological Process — broad objective or goal mitosis, signal transduction, metabolism •Cellular Component — location or complex nucleus, ribosome, origin recognition complex What GO is NOT: • Not a way to unify biological databases • Not a dictated standard • Does not define evolutionary relationships • Additional ontologies needed to model biology and experimentation Terms outside the Scope of GO • Names of gene products • Protein domains • Protein sequence features • Phenotypes; diseases • Anatomical terms generated by cross-products) (except as part of terms The GOBO Proposal • Global Open Biology Ontologies • Umbrella site for shared genomics and proteomics vocabularies • Present incarnation: subdirectory within GO repository: ftp://ftp.geneontology.org/pub/go/gobo/README GOBO Criteria • Open source • Can be instantiated in DAML+OIL or GO syntax • Orthogonal • Shared ID space • Defined terms DAG Cross-Products hexose glucose fructose metabolism biosynthesis catabolism hexose metabolism hexose biosynthesis glucose biosynthesis fructose biosynthesis hexose catabolism glucose catabolism fructose catabolism glucose metabolism ... etc. Some GOBO Ontologies gene gene_attribute gene_structure SO gene_variation ME gene_product gene_product_attribute molecular_function GO protein_family INTERPRO phenotype mutant phenotype anatomy For complete current draft see ftp://ftp.geneontology.org/pub/go/gobo/README www.geneontology.org • • • • • FlyBase & Berkeley Drosophila Genome Project Saccharomyces Genome Database Mouse Genome Informatics The Arabidopsis Information Resource Swiss-Prot/TrEMBL/InterPro • WormBase • DictyBase • Compugen, Inc • Pathogen Sequencing Unit (Sanger Institute) • PomBase (Sanger Institute) • Rat Genome Database • Genome Knowledge Base (CSHL) • The Institute for Genomic Research The Gene Ontology Consortium is supported by NHGRI grant HG02273 (R01). The Gene Ontology project thanks AstraZeneca for financial support. The Stanford group acknowledges a gift from Incyte Genomics.