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Transcript
Carlos Montalvo Foy H. Moody High School; Corpus Christi ISD Faculty Mentor: Dr. Zhengdong Cheng Artie McFerrin Dept. of Chemical Engineering B.S., University of Science and Technology of China, Hefei, China, 1990 M.S., Institute of High Energy Physics, Beijing, China, 1993 Ph.D., Princeton University, 1999 Postdoc, ExxonMobil, 1999-2000 DiCon Fiberoptics Inc., 2001-2002 Postdoc, Harvard Universtiy, 20022004 Colloid Chemistry Colloid—type of mechanical mixture where one substance is dispersed evenly throughout another. Aspects of Research Colloidal Crystal Growth Engineering and ordering large crystals to create photonic band gaps for optical computers Discotic Colloids Study the flow and movement of disk like molecules such as red blood cells Cell Encapsulation Using microreactors to create a protective “bubble” over a cell for possible drug delivery Crystal Structure Review How are Colloids and Crystal structures related? Colloidal Crystals!! 0 min 25 min 4 min 89 min 11 min 152 min Reason for Understanding Colloidal Crystals Optical Computers Optical Computer Discotic Colloids Emulsification—process by which one liquid is dispersed into another in the form of small droplets (http://www.pwsrcac.org/resources/glossary.html) • Wax with 1% STADIS-450 • Flow Rate : 4ml/h • Voltage: 2.8 kV Electrospray Electrospray Ionization technique where droplets are created in an electric field An electric force is applied to a liquid surface Wax Emulsion Eicosene (wax) Formation of droplets Lower temperature to form disks Disk Forming Electrospray cooling forms disks similar to shape of Red Blood Cell Cell Encapsulation Placing a cell into a protective membrane that is not immunosuppressed. Cell Encapsulation: concept Encapsulate cells of interest in semi-permeable membrane Implant cell capsules Cells release therapeutic substances Advantages Immunoisolation Natural therapeutic response Applications Diabetes (type I) Hemophilia Cancer Renal failure Dr. Dawei Luo Cell Encapsulation Confocal microscope imaging shows the uniform shape of alginate disks. Fluorescence shows successful encapsulation of colloidal particles. Microfluidics Microfluidics water oil oil oil oil water Microfluidics Microreactors using microfluidics Experiments to be Conducted Formation of microdisks using Electrospray technique Droplet Formation Using Electrospray Experiments to be Conducted Study the size and variation of the wax disks as electrospray settings are changed Study how the disks flow through various substances (ie.—red blood cell flow) Observe and study encapsulation techniques Attempt to add protective coating to encapsulations Aspects of Research Colloidal crystal growth Disk formation using Electrospray Cell encapsulation using Electrospray and microfluidics Classroom Activities??? Dr. Zhengdong Cheng Andres Mejia Lucas Kinard National Science Foundation